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Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method.

Abstract：

OBJECTIVE:Many studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study assessed whether N3 correction processing provides reduced system dependency in atlas-based volumetry. MATERIALS AND METHODS:Contiguous sagittal T1-weighted images of the brain were obtained from 21 healthy participants, by using five magnetic resonance protocols. After image preprocessing using the Statistical Parametric Mapping 5 software, we measured the structural volume of the segmented images with the WFU-PickAtlas software. We applied six different bias-correction levels (Regularization 10, Regularization 0.0001, Regularization 0, Regularization 10 with N3, Regularization 0.0001 with N3, and Regularization 0 with N3) to each set of images. The structural volume change ratio (%) was defined as the change ratio (%) = (100 × [measured volume - mean volume of five magnetic resonance protocols] / mean volume of five magnetic resonance protocols) for each bias-correction level. RESULTS:A low change ratio was synonymous with lower system dependency. The results showed that the images with the N3 correction had a lower change ratio compared with those without the N3 correction. CONCLUSION:The present study is the first atlas-based volumetry study to show that the precision of atlas-based volumetry improves when using N3-corrected images. Therefore, correction for signal intensity non-uniformity is strongly advised for multi-scanner or multi-site imaging trials.

journal_name

Korean J Radiol

journal_title

Korean journal of radiology

authors

Goto M,Abe O,Miyati T,Kabasawa H,Takao H,Hayashi N,Kurosu T,Iwatsubo T,Yamashita F,Matsuda H,Mori H,Kunimatsu A,Aoki S,Ino K,Yano K,Ohtomo K,Japanese Alzheimer's Disease Neuroimaging Initiative.

doi

10.3348/kjr.2012.13.4.391

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

391-402

issue

eissn

1229-6929

issn

2005-8330

journal_volume

pub_type

杂志文章

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Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method.