当前位置： SCI文献检索 > KOREAN JOURNAL OF RADIOLOGY期刊下所有文献 > Radiofrequency ablation of the gastrointestinal tract with a stent-like electrode: experimental study.

Radiofrequency ablation of the gastrointestinal tract with a stent-like electrode: experimental study.

Abstract：

OBJECTIVE:To assess the technical feasibility of a newly designed stent-like electrode in rabbits. MATERIALS AND METHODS:A stent-like electrode was knitted from a single thread of nitinol wire and interconnected to a generator using similar wire. In order to gauge the extent of radiofrequency ablation (RFA), we measured the depth of the ablated area in cow liver using a combination of 180-sec time intervals and 20-watt power increments. For data processing, Cox regression analysis was used. RFA was also applied to the small intestine of rabbits using this stent-like electrode under six different sets of conditions: 10 watts for 1 min, 10 watts for 2 mins, 20 watts for 1 min, 20 watts for 2 mins, 30 watts for 1 min, and 30 watts for 2 mins. To determine the gross and microscopic findings, six animals were sacrificed immediately after the procedure and the results obtained under the different sets of conditions were correlated. Eight rabbits were monitored for 4 weeks prior to sacrifice. RESULTS:For both ex-vivo and in-vivo ablations, the depth of the thermal lesion showed linear correlation with both the duration of RFA and the power applied. RFA of the duodenum was technically successful in all 14 rabbits. The acute changes occurring in the rabbits' small intestine included color change, cytoplasmic denaturation, fibrin deposition and hemorrhage, among which hemorrhage of the mucosal layer was the earliest finding. RF ablation for 2 mins at 30 watts caused serosal hemorrhage. The gross and histologic changes occurring showed close correlation under all six sets of conditions. CONCLUSION:Use of the stent-like electrode proves technically feasible but to determine the nature of the chronic change occurring in the gastrointestinal tract after RF ablation, further investigation and long-term follow-up in animals are required.

journal_name

Korean J Radiol

journal_title

Korean journal of radiology

authors

Byun JN,Kang SG,Choi JY,Kim DH,Lee JM,Kim YC,Ki KH,Lee CG

doi

10.3348/kjr.2003.4.1.19

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

19-26

issue

eissn

1229-6929

issn

2005-8330

pii

2003v4n1p19

journal_volume

pub_type

杂志文章

在线工具

Radiofrequency ablation of the gastrointestinal tract with a stent-like electrode: experimental study.