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The significance of perfusion defect at myocardial perfusion MR imaging in a cat model of acute reperfused myocardial infarction.

Abstract：

OBJECTIVE:To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction. MATERIALS AND METHODS:In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes. At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17. The size of the perfusion defect was measured and compared with both the corresponding unstained area seen at triphenyl tetrazolium chloride (TTC) staining and the hyperenhanced area seen at gadophrin-2- enhanced MR imaging performed in the same cat six hours after myocardial perfusion MR imaging. RESULTS:The sizes of perfusion defects seen at gadomer-17-enhanced perfusion MR imaging, unstained areas at TTC staining, and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4+/-4.3%, 29.0+/-9.7%, and 30.7+/- 10.6% of the left ventricular myocardium, respectively. The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than the unstained areas at TTC staining and hyperenhanced areas at gadophrin-2- enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2- enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively). CONCLUSION:In this cat model, the perfusion defect revealed by myocardial perfusion MR imaging underestimated the true size of acute reperfused myocardial infarction. The defect may represent a more severely damaged area of infarction and probably has prognostic significance.

journal_name

Korean J Radiol

journal_title

Korean journal of radiology

authors

Goo HW,Kim DH,Lee SS,Park SB,Lim TH

doi

10.3348/kjr.2002.3.4.235

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

235-9

issue

eissn

1229-6929

issn

2005-8330

pii

2002v3n4p235

journal_volume

pub_type

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The significance of perfusion defect at myocardial perfusion MR imaging in a cat model of acute reperfused myocardial infarction.