Abstract:
OBJECTIVE:To investigate the diagnostic performance of coronary computed tomography angiography (CCTA), stress dual-energy computed tomography perfusion (DE-CTP), stress perfusion single-photon emission computed tomography (SPECT), and the combinations of CCTA with myocardial perfusion imaging (CCTA + DE-CTP and CCTA + SPECT) for identifying coronary artery stenosis that causes myocardial hypoperfusion. Combined invasive coronary angiography (ICA) and stress perfusion cardiac magnetic resonance (SP-CMR) imaging are used as the reference standard. MATERIALS AND METHODS:We retrospectively reviewed the records of 25 patients with suspected coronary artery disease, who underwent CCTA, DE-CTP, SPECT, SP-CMR, and ICA. The reference standard was defined as ≥ 50% stenosis by ICA, with a corresponding myocardial hypoperfusion on SP-CMR. RESULTS:For per-vascular territory analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 96, 96, 68, 93, and 68%, respectively, and specificities were 72, 75, 89, 85, and 94%, respectively. The areas under the receiver operating characteristic curve (AUCs) were 0.84 ± 0.05, 0.85 ± 0.05, 0.79 ± 0.06, 0.89 ± 0.04, and 0.81 ± 0.06, respectively. For per-patient analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 100, 100, 89, 100, and 83%, respectively; the specificities were 14, 43, 57, 43, and 57%, respectively; and the AUCs were 0.57 ± 0.13, 0.71 ± 0.11, 0.73 ± 0.11, 0.71 ± 0.11, and 0.70 ± 0.11, respectively. CONCLUSION:The combination of CCTA and DE-CTP enhances specificity without a loss of sensitivity for detecting hemodynamically significant coronary artery stenosis, as defined by combined ICA and SP-CMR.
journal_name
Korean J Radioljournal_title
Korean journal of radiologyauthors
Chung HW,Ko SM,Hwang HK,So Y,Yi JG,Lee EJdoi
10.3348/kjr.2017.18.3.476subject
Has Abstractpub_date
2017-05-01 00:00:00pages
476-486issue
3eissn
1229-6929issn
2005-8330journal_volume
18pub_type
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journal_title:Korean journal of radiology
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journal_title:Korean journal of radiology
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journal_title:Korean journal of radiology
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journal_title:Korean journal of radiology
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doi:10.3348/kjr.2018.0204
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2011.12.3.390
更新日期:2011-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
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journal_title:Korean journal of radiology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,实务指引
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更新日期:2015-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.2.134
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pub_type: 杂志文章,评审
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journal_title:Korean journal of radiology
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journal_title:Korean journal of radiology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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更新日期:2010-09-01 00:00:00
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