Abstract:
OBJECTIVE:The purpose of this study was to establish a minimally invasive and reproducible protocol for estimating the gastrointestinal (GI) transit time in mice using barium and radiopaque markers. MATERIALS AND METHODS:Twenty 5- to 6-week-old Balb/C female mice weighing 19-21 g were used. The animals were divided into three groups: two groups that received loperamide and a control group. The control group (n = 10) animals were administered physiological saline (1.5 mL/kg) orally. The loperamide group I (n = 10) and group II (n = 10) animals were administered 5 mg/kg and 10 mg/kg loperamide orally, respectively. Thirty minutes after receiving the saline or loperamide, the mice was administered 80 µL of barium solution and six iron balls (0.5 mm) via the mouth and the upper esophagus by gavage, respectively. Afterwards, the mice were continuously monitored with fluoroscopic imaging in order to evaluate the swallowing of the barium solution and markers. Serial fluoroscopic images were obtained at 5- or 10-min intervals until all markers had been excreted from the anal canal. For analysis, the GI transit times were subdivided into intestinal transit times (ITTs) and colon transit times (CTTs). RESULTS:The mean ITT was significantly longer in the loperamide groups than in the control group (p < 0.05). The mean ITT in loperamide group II (174.5 ± 32.3) was significantly longer than in loperamide group I (133.2 ± 24.2 minute) (p < 0.05). The mean CTT was significantly longer in loperamide group II than in the control group (p < 0.05). Also, no animal succumbed to death after the experimental procedure. CONCLUSION:The protocol for our study using radiopaque markers and barium is reproducible and minimally invasive in determining the GI transit time of the mouse model.
journal_name
Korean J Radioljournal_title
Korean journal of radiologyauthors
Myagmarjalbuu B,Moon MJ,Heo SH,Jeong SI,Park JS,Jun JY,Jeong YY,Kang HKdoi
10.3348/kjr.2013.14.1.45subject
Has Abstractpub_date
2013-01-01 00:00:00pages
45-50issue
1eissn
1229-6929issn
2005-8330journal_volume
14pub_type
杂志文章abstract::The aim of this systematic review was to describe the characteristics of prostate-specific membrane antigen (PSMA)-targeting PET and their clinical applications in prostate cancer patients. There have been major strides in the design, synthesis of PSMA-targeting PET tracers over the past several years. PSMA-targeting ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.19.5.819
更新日期:2018-09-01 00:00:00
abstract::Diabetes mellitus (DM) can accompany many musculoskeletal (MSK) diseases. It is difficult to distinguish the DM-related MSK diseases based on clinical symptoms alone. Sonography is frequently used as a first imaging study for these MSK symptoms and is helpful to differentiate the various DM-related MSK diseases. This ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2016.17.2.245
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Although three-dimensional time-of-flight magnetic resonance angiography (3D TOF-MRA) is used frequently as a follow-up tool to assess the response of arteriovenous malformations (AVMs) after radiosurgery, the diagnostic accuracy of 3D TOF-MRA is not well known. We evaluated the diagnostic accuracy of contras...
journal_title:Korean journal of radiology
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更新日期:2009-07-01 00:00:00
abstract:Objective:To investigate the technical safety and clinical efficacy of a double-stent system with long duodenal extension in patients with malignant extrahepatic biliary obstruction. Materials and Methods:This prospective study enrolled 48 consecutive patients (31 men, 17 women; mean age, 61 years; age range, 31-77 ye...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.19.2.230
更新日期:2018-03-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2001.2.4.222
更新日期:2001-10-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous expon...
journal_title:Korean journal of radiology
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doi:10.3348/kjr.2018.0474
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:1) To evaluate the mid-term efficacy and safety of a permanent nitinol inferior vena cava (IVC) filter; 2) to evaluate filter effectiveness, filter stability and caval occlusion. MATERIALS AND METHODS:A prospective evaluation of the TrapEase IVC filter was performed on 42 patients (eight men, 34 women) rangi...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2005.6.2.110
更新日期:2005-04-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.0897
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2007.8.5.452
更新日期:2007-09-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.1.93
更新日期:2009-01-01 00:00:00
abstract::Primary lymphoma of the uterus is a rare disease, the reported characteristic MR imaging findings being homogeneous intermediate signal intensity of the indistinct mass on T1- and T2-weighted images, and the preservation of endometrial lining and uterine architecture. We report a case of primary uterine lymphoma which...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2000.1.4.223
更新日期:2000-10-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2006.7.4.267
更新日期:2006-10-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.3.476
更新日期:2017-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.2.299
更新日期:2017-03-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.6.552
更新日期:2009-11-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.6.1303
更新日期:2015-11-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3348/kjr.2020.0011
更新日期:2021-02-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
abstract::Placenta accreta spectrum (PAS) is an abnormal placental adherence or invasion of the myometrium or extrauterine structures. As PAS is primarily staged and managed surgically, imaging can only guide and facilitate diagnosis. But, imaging can aid in preparations for surgical complexity in some cases of PAS. Ultrasound ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
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更新日期:2021-02-01 00:00:00
abstract::We describe the imaging features of two cases of biliary ascariasis. Ultrasonography and CT showed no specific abnormal findings, but MR cholangiography clearly demonstrated an intraductal linear filling defect that led to the correct diagnosis. MR cholangiography is thus a useful technique for the diagnosis of biliar...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2001.2.3.175
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae. MATERIALS AND METHODS:We assessed 32 l...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.6.781
更新日期:2014-11-01 00:00:00
abstract::Immunoglobulin G4 (IgG4)-related kidney disease (IgG4-KD) has recently been demonstrated to be an important part of IgG4-related sclerosing disease (IgG4-SD). However, since IgG4-KD is still relatively unfamiliar to radiologists and physicians as compared to IgG4-SD involving other organs, it could, therefore, be easi...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.19.3.425
更新日期:2018-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.2.144
更新日期:2009-03-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.6.697
更新日期:2014-11-01 00:00:00
abstract::A tumoral pseudoangiomatous stromal hyperplasia (PASH) that causes huge breast enlargement is very rare. Only two cases of huge tumoral PASHs have been reported in the English medical literature. We report here on a surgically confirmed case of bilateral huge tumoral PASH in a 47-year-old woman, and we present the ima...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.3.355
更新日期:2010-05-01 00:00:00
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journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2012.13.S1.S67
更新日期:2012-01-01 00:00:00