Abstract:
OBJECTIVE:To evaluate the association of MRI features with the major genomic profiles and prognosis of World Health Organization grade III (G3) gliomas compared with those of glioblastomas (GBMs). MATERIALS AND METHODS:We enrolled 76 G3 glioma and 155 GBM patients with pathologically confirmed disease who had pretreatment brain MRI and major genetic information of tumors. Qualitative and quantitative imaging features, including volumetrics and histogram parameters, such as normalized cerebral blood volume (nCBV), cerebral blood flow (nCBF), and apparent diffusion coefficient (nADC) were evaluated. The G3 gliomas were divided into three groups for the analysis: with this isocitrate dehydrogenase (IDH)-mutation, IDH mutation and a chromosome arm 1p/19q-codeleted (IDHmut1p/19qdel), IDH mutation, 1p/19q-nondeleted (IDHmut1p/19qnondel), and IDH wildtype (IDHwt). A prediction model for the genetic profiles of G3 gliomas was developed and validated on a separate cohort. Both the quantitative and qualitative imaging parameters and progression-free survival (PFS) of G3 gliomas were compared and survival analysis was performed. Moreover, the imaging parameters and PFS between IDHwt G3 gliomas and GBMs were compared. RESULTS:IDHmut G3 gliomas showed a larger volume (p = 0.017), lower nCBF (p = 0.048), and higher nADC (p = 0.007) than IDHwt. Between the IDHmut tumors, IDHmut1p/19qdel G3 gliomas had higher nCBV (p = 0.024) and lower nADC (p = 0.002) than IDHmut1p/19qnondel G3 gliomas. Moreover, IDHmut1p/19qdel tumors had the best prognosis and IDHwt tumors had the worst prognosis among G3 gliomas (p < 0.001). PFS was significantly associated with the 95th percentile values of nCBV and nCBF in G3 gliomas. There was no significant difference in neither PFS nor imaging features between IDHwt G3 gliomas and IDHwt GBMs. CONCLUSION:We found significant differences in MRI features, including volumetrics, CBV, and ADC, in G3 gliomas, according to IDH mutation and 1p/19q codeletion status, which can be utilized for the prediction of genomic profiles and the prognosis of G3 glioma patients. The MRI signatures and prognosis of IDHwt G3 gliomas tend to follow those of IDHwt GBMs.
journal_name
Korean J Radioljournal_title
Korean journal of radiologyauthors
Hong EK,Choi SH,Shin DJ,Jo SW,Yoo RE,Kang KM,Yun TJ,Kim JH,Sohn CH,Park SH,Won JK,Kim TM,Park CK,Kim IH,Lee STdoi
10.3348/kjr.2020.0011subject
Has Abstractpub_date
2021-02-01 00:00:00pages
233-242issue
2eissn
1229-6929issn
2005-8330pii
21.e150journal_volume
22pub_type
杂志文章abstract::Immunoglobulin G4 (IgG4)-related sclerosing disease is a systemic disease characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration in various organs. We described the imaging findings of an IgG4-related inflammatory pseudotumor in the urethra. The urethral mass showed isoattenuation on unenh...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.6.803
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:We wanted to introduce a new technique for superselective catheterization of arteries with preshaping of a micro-guide wire into a shepherd's hook form, and this is useful for superselection of small arteries branching at an acute angle from a large parent artery for the treatment of tumors and hemorrhages. ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2007.8.3.225
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of radiation dose and reconstruction algorithms on radiologists' preferences, and whether an iterative reconstruction in image space (IRIS) can be used for dose reduction in chest CT. MATERIALS AND METHODS:Standard dose chest CT (SDCT) in 50 patients and low dose chest CT (LDCT) in ano...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.6.720
更新日期:2012-11-01 00:00:00
abstract::Pericardial fat necrosis is an infrequent cause of acute chest pain and this can mimic acute myocardial infarction and acute pericarditis. We describe here a patient with the magnetic resonance imaging (MRI) findings of pericardial fat necrosis and this was correlated with the computed tomography (CT) findings. The MR...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2011.12.3.390
更新日期:2011-05-01 00:00:00
abstract:Objective:To assess clinical feasibility of low-attenuation cluster analysis in evaluation of chronic obstructive pulmonary disease (COPD). Materials and Methods:Subjects were 199 current and former cigarette smokers that underwent CT for quantification of COPD and had physiological measurements. Quantitative CT (QCT)...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.19.1.139
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To survey care providers' willingness to use 2-mSv computed tomography (CT) in their usual practice for adolescents and young adults with suspected appendicitis. MATERIALS AND METHODS:An ethical committee approved this prospective study. We introduced 2-mSv CT in 20 hospitals through a pragmatic clinical tri...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2019.0010
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Many studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.4.391
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous expon...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.0474
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the incidence and risk factors of infections associated with implantable venous access ports (IVAPs). MATERIALS AND METHODS:From August 2003 through November 2011, 1747 IVAPs were placed in our interventional radiology suite. One hundred forty four IVAPs were insert...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.4.494
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between apparent diffusion coefficient (ADC) values on diffusion-weighted magnetic resonance (MR) imaging and pathologic measures of a tumor using a prostate cancer xenograft model. MATERIALS AND METHODS:Eighteen athymic nude mice with 36 PC-3-induced tumors were sacrificed to obta...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.1.82
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate spine magnetic resonance imaging (MRI) inter-reader and intra-reader reliabilities using the thoracolumbar injury classification system and severity score (TLICS) and to analyze the effects of reader experience on reliability and the possible reasons for discordant interpretations. MATERIALS AND ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.4.889
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:We wanted to investigate the hemodynamic effect of fenestrated stents on the renal arteries with using a fluid structure interaction method. MATERIALS AND METHODS:Two representative patients who each had abdominal aortic aneurysm that was treated with fenestrated stent grafts were selected for the study. 3D ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.1.95
更新日期:2010-01-01 00:00:00
abstract::Central diabetes insipidus (DI) can be the outcome of a number of diseases that affect the hypothalamic-neurohypophyseal axis. The causes of the condition can be classified as traumatic, inflammatory, or neoplastic. Traumatic causes include postoperative sella or transection of the pituitary stalk, while infectious or...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2001.2.4.222
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the clinical outcomes of the cervical interlaminar epidural steroid injection (CIESI) for unilateral radiculopathy by the midline or paramedian approaches and to determine the prognostic factors of CIESI. MATERIALS AND METHODS:We retrospectively analyzed 182 patient...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.3.604
更新日期:2015-05-01 00:00:00
abstract::Rectal submucosal lesions encompass a wide variety of benign and malignant tumors involving the rectum. With optical colonoscopy, any mass-like protrusion covered by normal mucosa, whether the underlying process is intramural or extramural in origin, may be reported as a submucosal lesion. Whereas the assessment of su...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2011.12.4.487
更新日期:2011-07-01 00:00:00
abstract::Endoscopic therapy by balloon dilation and placement of multiple large-bore plastic stents is the treatment of choice for benign biliary stricture. This approach is effective but it typically requires multiple endoscopic sessions given the short duration of stent patency. The endoscopic approach for treatment of bile ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2012.13.S1.S67
更新日期:2012-01-01 00:00:00
abstract::This paper is a summary of the methodology including protocol used to develop evidence-based clinical imaging guidelines (CIGs) in Korea, led by the Korean Society of Radiology and the National Evidence-based Healthcare Collaborating Agency. This is the first protocol to reflect the process of developing diagnostic gu...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2017.18.1.208
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We wanted to evaluate the image quality, diagnostic accuracy and radiation exposure of 64-slice dual-source CT (DSCT) coronary angiography according to the heart rate in symptomatic patients during daily clinical practice. MATERIALS AND METHODS:We performed a retrospective search for the DSCT coronary angiog...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2011.12.3.308
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To assess left ventricular remodeling patterns using cardiac computed tomography (CT) in children with congenital heart disease and correlate these patterns with their clinical course. MATERIALS AND METHODS:Left ventricular volume and myocardial mass were quantified in 17 children with congenital heart disea...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2019.0689
更新日期:2020-06-01 00:00:00
abstract::Degenerating nodules (DNs), which primarily manifest as benign thyroid nodules, are one of the main causes of discordance in ultrasonography (US) and cytological assessments. Intranodular hemorrhage is one of the mechanisms contributing to discordant nodules, and an impaired blood supply may explain further DN shrinka...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.0599
更新日期:2019-06-01 00:00:00
abstract::A 36-year-old man was diagnosed with a right temporal lobe grade II cerebral arteriovenous malformation (cAVM) and was treated with radiosurgery. At nine months after the cAVM radiosurgery, the patient began to develop bilateral focal narrowing at the M1 segments of the bilateral middle cerebral arteries. The narrowin...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.s.s65
更新日期:2008-07-01 00:00:00
abstract:Objective:To investigate the technical safety and clinical efficacy of a double-stent system with long duodenal extension in patients with malignant extrahepatic biliary obstruction. Materials and Methods:This prospective study enrolled 48 consecutive patients (31 men, 17 women; mean age, 61 years; age range, 31-77 ye...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.19.2.230
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features of MCF-7 and MDA-MB-231 xenograft models. MATERIALS AND METHODS:MCF-7 estradiol (+), MCF-7 estradiol (-), and MDA-MB-231 xenograft models were made with...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.5.591
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of hepatic radiofrequency ablation (RFA) in patients with malignant liver disease with respect to inflammation activation and stress response. MATERIALS AND METHODS:In an observational trial, we investigated the physiologic parameters of 17 patients (20 interventions) who underwent...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.6.640
更新日期:2010-11-01 00:00:00
abstract::Breast capillary hemangioma is a type of benign vascular tumor which is rarely seen. Little is known about its presentation on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Here, we describe a case of suspicious breast lesion detected by DCE-MRI and pathologically confirmed as capillary hemangioma. O...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2013.14.6.869
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To compare the contrast-enhanced fluid-attenuated inversion recovery (CE-FLAIR), the CE T1-weighted (CE-T1W) sequence with fat suppression (FS) and magnetization transfer (MT) for early detection and characterization of infectious meningitis. MATERIALS AND METHODS:Fifty patients and 10 control subjects were ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.6.973
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the correlations between prostate volumes estimated by transabdominal, transrectal, and three-dimensional US and the factors affecting the differences. MATERIALS AND METHODS:The prostate volumes of 94 consecutive patients were measured by both transabdominal and transrectal US. Next, the prostate...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.2.134
更新日期:2008-03-01 00:00:00
abstract::We report two cases of paratracheal air cyst discovered incidentally at neck ultrasonography and confirmed at CT. The cysts were located at the inferoposterior aspect of the right lobe of the thyroid. Ultrasonography revealed an ill-defined hypoechoic mass containing hyperechoic foci which mimicked calcifications. Nec...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2003.4.2.136
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:This study was designed to develop an automated system for quantification of various regional disease patterns of diffuse lung diseases as depicted on high-resolution computed tomography (HRCT) and to compare the performance of the automated system with human readers. MATERIALS AND METHODS:A total of 600 cir...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.5.455
更新日期:2009-09-01 00:00:00
abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...
journal_title:Korean journal of radiology
pub_type: 杂志文章,实务指引
doi:10.3348/kjr.2015.16.3.465
更新日期:2015-05-01 00:00:00