Diffusion-weighted imaging of a prostate cancer xenograft model seen on a 7 Tesla animal MR scanner: comparison of ADC values and pathologic findings.


OBJECTIVE:To assess the relationship between apparent diffusion coefficient (ADC) values on diffusion-weighted magnetic resonance (MR) imaging and pathologic measures of a tumor using a prostate cancer xenograft model. MATERIALS AND METHODS:Eighteen athymic nude mice with 36 PC-3-induced tumors were sacrificed to obtain specimens immediately after MR imaging in order to compare the findings on MR images with those seen on pathological specimens. Using a high-field small-animal MR scanner, T1- and T2-weighted imaging and DW MR imaging was performed. Tumors were then processed for Hematoxylin and Eosin staining to evaluate tumor cellularity, intratumoral necrosis and immunostaining using antibodies directed against CD31 and vascular endothelial growth factor (VEGF) to determine the levels of microvessel density (MVD). Mean ADC values that were measured on the solid portion within each tumor were compared with tumor volume, cellularity, degree of necrosis, VEGF expression, and MVD in the corresponding section of the pathological specimen. RESULTS:Mean ADC values of the solid portion within the PC-3-induced high-grade tumors were significantly correlated with the degree of intratumoral necrosis (r = 0.63, p < 0.0001) and MVD (r = -0.44, p = 0.008) on pathologic slides. The ADC values were not significantly correlated with tumor cellularity, VEGF expression, or tumor volume in high-grade prostate cancer tissues. CONCLUSION:In the xenografted prostate cancer model, the ADC values of the solid portion of the tumors are significantly correlated with tumor necrosis and MVD of the pathologic specimens. The ADC values may be utilized as surrogate markers for the noninvasive assessment of tumor necrosis and MVD in high-grade prostate cancer.


Korean J Radiol


Jung DC,Lee HJ,Seo JW,Park SY,Lee SJ,Lee JH,Kim IH




Has Abstract


2012-01-01 00:00:00












  • Radiofrequency ablation combined with transcatheter arterial chemoembolization for the treatment of single hepatocellular carcinoma of 2 to 5 cm in diameter: comparison with surgical resection.

    abstract:OBJECTIVE:To compare the effectiveness of radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) with surgical resection in patients with a single hepatocellular carcinoma (HCC) ranging from 2 to 5 cm. MATERIALS AND METHODS:The study participants were enrolled over a period of 29 m...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Kim JW,Shin SS,Kim JK,Choi SK,Heo SH,Lim HS,Hur YH,Cho CK,Jeong YY,Kang HK

    更新日期:2013-07-01 00:00:00

  • Intratumoral heterogeneity of breast cancer xenograft models: texture analysis of diffusion-weighted MR imaging.

    abstract:OBJECTIVE:To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features of MCF-7 and MDA-MB-231 xenograft models. MATERIALS AND METHODS:MCF-7 estradiol (+), MCF-7 estradiol (-), and MDA-MB-231 xenograft models were made with...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Yun BL,Cho N,Li M,Jang MH,Park SY,Kang HC,Kim B,Song IC,Moon WK

    更新日期:2014-09-01 00:00:00

  • Perfusion imaging of the brain using Z-score and dynamic images obtained by subtracting images from before and after contrast injection.

    abstract:OBJECTIVE:The aim of this study was to examine the feasibility of perfusion imaging of the brain using the Z-score and subtraction dynamic images obtained from susceptibility contrast MR images. MATERIALS AND METHODS:Five patients, each with a normal MRI, Moya-moya, a middle cerebral artery occlusion, post-trauma synd...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Choi S,Liu H,Shin TB,Lee JH,Yoon SK,Oh JY,Lee YI

    更新日期:2004-07-01 00:00:00

  • Assessment of Myocardial Bridge by Cardiac CT: Intracoronary Transluminal Attenuation Gradient Derived from Diastolic Phase Predicts Systolic Compression.

    abstract:OBJECTIVE:To study the predictive value of transluminal attenuation gradient (TAG) derived from diastolic phase of coronary computed tomography angiography (CCTA) for identifying systolic compression of myocardial bridge (MB). MATERIALS AND METHODS:Consecutive patients diagnosed with MB based on CCTA findings and with...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Yu M,Zhang Y,Li Y,Li M,Li W,Zhang J

    更新日期:2017-07-01 00:00:00

  • The diagnostic accuracy, image quality and radiation dose of 64-slice dual-source CT in daily practice: a single institution's experience.

    abstract:OBJECTIVE:We wanted to evaluate the image quality, diagnostic accuracy and radiation exposure of 64-slice dual-source CT (DSCT) coronary angiography according to the heart rate in symptomatic patients during daily clinical practice. MATERIALS AND METHODS:We performed a retrospective search for the DSCT coronary angiog...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Moon JH,Park EA,Lee W,Yin YH,Chung JW,Park JH,Lee HY,Kang HJ,Kim HS

    更新日期:2011-05-01 00:00:00

  • Update on Gastrointestinal Stromal Tumors for Radiologists.

    abstract::The management of gastrointestinal stromal tumors (GISTs) has evolved significantly in the last two decades due to better understanding of their biologic behavior as well as development of molecular targeted therapies. GISTs with exon 11 mutation respond to imatinib whereas GISTs with exon 9 or succinate dehydrogenase...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Tirumani SH,Baheti AD,Tirumani H,O'Neill A,Jagannathan JP

    更新日期:2017-01-01 00:00:00

  • Histopathologic findings related to the indeterminate or inadequate results of fine-needle aspiration biopsy and correlation with ultrasonographic findings in papillary thyroid carcinomas.

    abstract:OBJECTIVE:To determine histopathologic findings related to the indeterminate or inadequate result of fine-needle aspiration biopsy (FNAB) in papillary thyroid carcinomas (PTCs) and to correlate histopathological findings with ultrasonographic features of tumors. MATERIALS AND METHODS:We retrospectively reviewed the me...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Jung SL,Jung CK,Kim SH,Kang BJ,Ahn KJ,Kim BS,Ahn MI,Im DJ,Bae JS,Chung SK

    更新日期:2010-03-01 00:00:00

  • Early hepatocellular carcinoma: three-phase helical CT features of 16 patients.

    abstract:OBJECTIVE:To evaluate the three-phase helical CT features of early hepatocellular carcinomas, based on the new Japanese classification. MATERIALS AND METHODS:Over the course of an eight-year period, we collected 16 pathologically proven early hepatocellular carcinomas from 16 patients having undergone a three-phase he...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Lee J,Lee WJ,Lim HK,Lim JH,Choi N,Park MH,Kim SW,Park CK

    更新日期:2008-07-01 00:00:00

  • Rapidly growing bilateral pseudoangiomatous stromal hyperplasia of the breast.

    abstract::A tumoral pseudoangiomatous stromal hyperplasia (PASH) that causes huge breast enlargement is very rare. Only two cases of huge tumoral PASHs have been reported in the English medical literature. We report here on a surgically confirmed case of bilateral huge tumoral PASH in a 47-year-old woman, and we present the ima...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Ryu EM,Whang IY,Chang ED

    更新日期:2010-05-01 00:00:00

  • Various tumor-mimicking lesions in the musculoskeletal system: causes and diagnostic approach.

    abstract::Tumor-mimicking lesions in the musculoskeletal system can be defined as lesions mistaken as tumors due to the presence of palpation upon physical examination or a tumor-like appearance upon radiological examination. Moreover, tumor-mimicking lesions show diverse etiologies and anatomic locations. We illustrated the va...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Kim SY,Park JS,Ryu KN,Jin W,Park SY

    更新日期:2011-03-01 00:00:00

  • Nipple Ultrasound: A Pictorial Essay.

    abstract::Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma in situ (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Chiorean A,Pintican RM,Szep M,Feier D,Rogojan L,Fetica B,Dindelegan G,Vlad B,Duma M

    更新日期:2020-08-01 00:00:00

  • Management of Adverse Reactions to Iodinated Contrast Media for Computed Tomography in Korean Referral Hospitals: A Survey Investigation.

    abstract:Objective:To evaluate the current status of managing adverse reactions to iodinated contrast media (ICM) for computed tomography in referral hospitals in South Korea compared with hospitals in other countries. Materials and Methods:This survey investigation involved 59 Korean and 15 overseas hospitals using guideline-...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Han S,Yoon SH,Lee W,Choi YH,Kang DY,Kang HR

    更新日期:2019-01-01 00:00:00

  • A computer-aided diagnosis for evaluating lung nodules on chest CT: the current status and perspective.

    abstract::As the detection and characterization of lung nodules are of paramount importance in thoracic radiology, various tools for making a computer-aided diagnosis (CAD) have been developed to improve the diagnostic performance of radiologists in clinical practice. Numerous studies over the years have shown that the CAD syst...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Goo JM

    更新日期:2011-03-01 00:00:00

  • An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient.

    abstract::The radiological appearance of diffuse discrete pulmonary nodules associated with cryptogenic organizing pneumonia (COP) has been rarely described. We describe a case of COP in 49-year-old woman with acute myeloid leukemia who developed diffuse pulmonary nodules during the second course of induction chemotherapy. The ...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Ko KH,Hsu HH,Kao WY,Chang CF,Cheng MF,Huang GS

    更新日期:2009-01-01 00:00:00

  • Erratum: Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy.

    abstract::[This corrects the article on p. 1153 in vol. 16, PMID: 26355278.]. ...

    journal_title:Korean journal of radiology

    pub_type: 已发布勘误


    authors: Yoon JH,Son JW,Chung H,Park CH,Kim YJ,Chang HJ,Hong GR,Kim TH,Ha JW,Choi BW,Rim SJ,Chung N,Choi EY

    更新日期:2015-11-01 00:00:00

  • Erratum: RE: An Unusual Course of Sinoatrial Node Artery Originating from Distal Right Coronary Artery.

    abstract::[This corrects the article on p. 878 in vol. 15, PMID: 25469103.]. ...

    journal_title:Korean journal of radiology

    pub_type: 已发布勘误


    authors: Kara K,Ozturk E,Saglam M

    更新日期:2015-01-01 00:00:00

  • Sonographic Findings of Common Musculoskeletal Diseases in Patients with Diabetes Mellitus.

    abstract::Diabetes mellitus (DM) can accompany many musculoskeletal (MSK) diseases. It is difficult to distinguish the DM-related MSK diseases based on clinical symptoms alone. Sonography is frequently used as a first imaging study for these MSK symptoms and is helpful to differentiate the various DM-related MSK diseases. This ...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Park M,Park JS,Ahn SE,Ryu KN,Park SY,Jin W

    更新日期:2016-03-01 00:00:00

  • Comparison of Urologist Satisfaction for Different Types of Prostate MRI Reports: A Large Sample Investigation.

    abstract:OBJECTIVE:To evaluate urologist satisfaction on structured prostate MRI reports, including report with tumor-node-metastasis (TNM) staging (report B) and with Prostate Imaging Reporting and Data System (PI-RADS) score with/without TNM staging (report C, report with PI-RADS score only [report C-a] and report with PI-RAD...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Zhong J,Qin W,Li Y,Wang Y,Huan Y,Ren J

    更新日期:2020-12-01 00:00:00

  • Quantification of Fat Concentration and Vascular Response in Brown and White Adipose Tissue of Rats by Spectral CT Imaging.

    abstract:OBJECTIVE:The purpose of the study was to non-invasively characterize and discriminate brown adipose tissue (BAT) from white adipose tissue (WAT) in rats using spectral computed tomography (CT) with histological validation. MATERIALS AND METHODS:A lipid-containing phantom (lipid fractions from 0% to 100%) was imaged w...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Peng XG,Zhao Z,Chang D,Bai Y,Xu Q,Ju S

    更新日期:2020-02-01 00:00:00

  • MR imaging findings of a primary cardiac osteosarcoma and its bone metastasis with histopathologic correlation.

    abstract::An osteosarcoma of cardiac origin is extremely rare, and a comprehensive description of MR imaging (MRI) findings of cardiac osteosarcoma and its metastasis in the femur have not been reported in the literature. We present a case of cardiac osteosarcoma in a 47-year-old woman and its metastasis to the femur, focusing ...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Ahn S,Choi JA,Chung JH,Choi H,Chun EJ,Choi SI,Kang HS

    更新日期:2011-01-01 00:00:00

  • Effect of papillary muscles and trabeculae on left ventricular measurement using cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy.

    abstract:OBJECTIVE:To evaluate the influence of papillary muscles and trabeculae on left ventricular (LV) cardiovascular magnetic resonance (CMR) analysis using three methods of cavity delineation (classic or modified inclusion methods, and the exclusion method) in patients with hypertrophic cardiomyopathy (HCM). MATERIALS AND...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Park EA,Lee W,Kim HK,Chung JW

    更新日期:2015-01-01 00:00:00

  • Significance of Low-Attenuation Cluster Analysis on Quantitative CT in the Evaluation of Chronic Obstructive Pulmonary Disease.

    abstract:Objective:To assess clinical feasibility of low-attenuation cluster analysis in evaluation of chronic obstructive pulmonary disease (COPD). Materials and Methods:Subjects were 199 current and former cigarette smokers that underwent CT for quantification of COPD and had physiological measurements. Quantitative CT (QCT)...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Nambu A,Zach J,Kim SS,Jin G,Schroeder J,Kim YI,Bowler R,Lynch DA

    更新日期:2018-01-01 00:00:00

  • Percutaneous Pancreatic Stent Placement for Postoperative Pancreaticojejunostomy Stenosis: A Case Report.

    abstract::Stenosis of the pancreatico-enteric anastomosis is one of the major complications of pancreaticoduodenectomy (PD). Endoscopic stent placement, has limited success rate as a nonsurgical treatment due to altered gastrointestinal anatomy. Percutaneous treatment is rarely attempted due to the technical difficulty in acces...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Yang SK,Yoon CJ

    更新日期:2016-09-01 00:00:00

  • Assessment of Blood-Brain Barrier Permeability by Dynamic Contrast-Enhanced MRI in Transient Middle Cerebral Artery Occlusion Model after Localized Brain Cooling in Rats.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of localized brain cooling on blood-brain barrier (BBB) permeability following transient middle cerebral artery occlusion (tMCAO) in rats, by using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS:Thirty rats were divided into 3 groups of 10 rat...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Kim ES,Lee SK,Kwon MJ,Lee PH,Ju YS,Yoon DY,Kim HJ,Lee KS

    更新日期:2016-09-01 00:00:00

  • Intraductal tubular carcinoma of the pancreas: a case report with the imaging findings.

    abstract::We describe here a case of intraductal tubular carcinoma of the main pancreatic duct. Gadolinium-enhanced pancreas magnetic resonance (MR) imaging showed an enhancing mass that was confined in the dilated main pancreatic duct of the pancreatic body, along with dilatation of the upstream main pancreatic duct and chroni...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Oh DK,Kim SH,Choi SH,Jang KT

    更新日期:2008-09-01 00:00:00

  • Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with T2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence.

    abstract:OBJECTIVE:To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae. MATERIALS AND METHODS:We assessed 32 l...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Kim YP,Kannengiesser S,Paek MY,Kim S,Chung TS,Yoo YH,Yoon CS,Song HT,Lee YH,Suh JS

    更新日期:2014-11-01 00:00:00

  • Combination of Quantitative Parameters of Shear Wave Elastography and Superb Microvascular Imaging to Evaluate Breast Masses.

    abstract:OBJECTIVE:This study aimed to evaluate the diagnostic value of combining the quantitative parameters of shear wave elastography (SWE) and superb microvascular imaging (SMI) to breast ultrasound (US) to differentiate between benign and malignant breast masses. MATERIALS AND METHODS:A total of 200 pathologically confirm...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Lee EJ,Chang YW

    更新日期:2020-09-01 00:00:00

  • Doppler US and CT Diagnosis of Nutcracker Syndrome.

    abstract::Nutcracker syndrome (NCS) is a syndrome caused by compression of the left renal vein (LRV), between the abdominal aorta and the superior mesenteric artery, resulting in hypertension of the LRV and hematuria. Doppler ultrasonography (US) has been commonly used for the diagnosis of NCS. However, several technical issues...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Kim SH

    更新日期:2019-12-01 00:00:00

  • In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.

    abstract::The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap wit...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章,评审


    authors: Kim H,Kim S,Lee HH,Heo H

    更新日期:2016-09-01 00:00:00

  • The influence of reconstruction algorithm and heart rate on coronary artery image quality and stenosis detection at 64-detector cardiac CT.

    abstract:OBJECTIVE:We wanted to evaluate the impact of two reconstruction algorithms (halfscan and multisector) on the image quality and the accuracy of measuring the severity of coronary stenoses by using a pulsating cardiac phantom with different heart rates (HRs). MATERIALS AND METHODS:Simulated coronary arteries with diffe...

    journal_title:Korean journal of radiology

    pub_type: 杂志文章


    authors: Wang YT,Yang CY,Hsiao JK,Liu HM,Lee WJ,Shen Y

    更新日期:2009-05-01 00:00:00