Abstract:
OBJECTIVE:To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features of MCF-7 and MDA-MB-231 xenograft models. MATERIALS AND METHODS:MCF-7 estradiol (+), MCF-7 estradiol (-), and MDA-MB-231 xenograft models were made with approval of the animal care committee. Twelve tumors of MCF-7 estradiol (+), 9 tumors of MCF-7 estradiol (-), and 6 tumors in MDA-MB-231 were included. Diffusion-weighted MR images were obtained on a 9.4-T system. An analysis of the first and second order texture analysis of ADC maps was performed. The texture analysis parameters and histopathologic features were compared among these groups by the analysis of variance test. Correlations between texture parameters and histopathologic features were analyzed. We also evaluated the intraobserver agreement in assessing the texture parameters. RESULTS:MCF-7 estradiol (+) showed a higher standard deviation, maximum, skewness, and kurtosis of ADC values than MCF-7 estradiol (-) and MDA-MB-231 (p < 0.01 for all). The contrast of the MCF-7 groups was higher than that of the MDA-MB-231 (p = 0.004). The correlation (COR) of the texture analysis of MCF-7 groups was lower than that of MDA-MB-231 (p < 0.001). The histopathologic analysis showed that Ki-67mean and Ki-67diff of MCF-7 estradiol (+) were higher than that of MCF-7 estradiol (-) or MDA-MB-231 (p < 0.05). The microvessel density (MVD)mean and MVDdiff of MDA-MB-231 were higher than those of MCF-7 groups (p < 0.001). A diffuse-multifocal necrosis was more frequently found in MDA-MB-231 (p < 0.001). The proportion of necrosis moderately correlated with the contrast (r = -0.438, p = 0.022) and strongly with COR (r = 0.540, p = 0.004). Standard deviation (r = 0.622, r = 0.437), skewness (r = 0.404, r = 0.484), and kurtosis (r = 0.408, r = 0.452) correlated with Ki-67mean and Ki-67diff (p < 0.05 for all). COR moderately correlated with Ki-67diff (r = -0.388, p = 0.045). Skewness (r = -0.643, r = -0.464), kurtosis (r = -0.581, r = -0.389), contrast (r = -0.473, r = -0.549) and COR (r = 0.588, r = 0.580) correlated with MVDmean and MVDdiff (p < 0.05 for all). CONCLUSION:The texture analysis of ADC maps may help to determine the intratumoral spatial heterogeneity of necrosis patterns, amount of cellular proliferation and the vascularity in MCF-7 and MDA-MB-231 xenograft breast cancer models.
journal_name
Korean J Radioljournal_title
Korean journal of radiologyauthors
Yun BL,Cho N,Li M,Jang MH,Park SY,Kang HC,Kim B,Song IC,Moon WKdoi
10.3348/kjr.2014.15.5.591subject
Has Abstractpub_date
2014-09-01 00:00:00pages
591-604issue
5eissn
1229-6929issn
2005-8330journal_volume
15pub_type
杂志文章abstract:OBJECTIVE:To evaluate the clinical efficacy as well as long-term clinical outcomes of superselective microcoil embolization for lower gastrointestinal bleeding (LGIB). MATERIALS AND METHODS:Between 1997 and 2009, 26 patients with intended transcatheter embolotherapy for LGIB were retrospectively reviewed. Embolization...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2013.14.2.259
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To describe radiologic findings of adenovirus pneumonia and to understand clinico-radiological features associated with progression to acute respiratory distress syndrome (ARDS) in patients with adenovirus pneumonia. MATERIALS AND METHODS:This study included 19 patients diagnosed with adenovirus pneumonia at...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2016.17.6.940
更新日期:2016-11-01 00:00:00
abstract::The rupture of an acute dissection of the ascending aorta into the space surrounding the pulmonary artery is an uncommon occurrence. No previous cases of transient pulmonary hypertension caused by a hematoma surrounding the pulmonary artery have been documented in the literature. Herein, we report a case of acute aort...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2004.5.2.139
更新日期:2004-04-01 00:00:00
abstract::The aim of this systematic review was to describe the characteristics of prostate-specific membrane antigen (PSMA)-targeting PET and their clinical applications in prostate cancer patients. There have been major strides in the design, synthesis of PSMA-targeting PET tracers over the past several years. PSMA-targeting ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.19.5.819
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Using a pulsating coronary artery phantom at high heart rate settings, we investigated the efficacy of a motion correction algorithm (MCA) to improve the image quality in dual-energy spectral coronary CT angiography (CCTA). MATERIALS AND METHODS:Coronary flow phantoms were scanned at heart rates of 60-100 be...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.6.881
更新日期:2017-11-01 00:00:00
abstract::Thyroid ultrasonography (US) plays a key role in the diagnosis and management of thyroid-related diseases. The aim of this article was to illustrate various pitfalls that can occur in utilizing thyroid US and techniques to prevent them. In this article, we present cases demonstrating the common pitfalls associated wit...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.2.267
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the correlations between prostate volumes estimated by transabdominal, transrectal, and three-dimensional US and the factors affecting the differences. MATERIALS AND METHODS:The prostate volumes of 94 consecutive patients were measured by both transabdominal and transrectal US. Next, the prostate...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.2.134
更新日期:2008-03-01 00:00:00
abstract::Conventional transcatheter arterial chemoembolization (c-TACE) is a widely used first-line palliative treatment for patients with unresectable hepatocellular carcinoma (HCC). Despite the effectiveness of c-TACE, to date, technique and procedure scheduling has not yet been standardized. Drug-eluting microspheres (DEMs)...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.0088
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To prospectively evaluate the performance of computed tomography perfusion imaging (CTPI) in predicting the early response to transarterial chemo-lipiodol infusion (TACLI) and survival of patients with colorectal cancer liver metastases (CRLM). MATERIALS AND METHODS:Computed tomography perfusion imaging was ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.4.810
更新日期:2015-07-01 00:00:00
abstract::A tumoral pseudoangiomatous stromal hyperplasia (PASH) that causes huge breast enlargement is very rare. Only two cases of huge tumoral PASHs have been reported in the English medical literature. We report here on a surgically confirmed case of bilateral huge tumoral PASH in a 47-year-old woman, and we present the ima...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.3.355
更新日期:2010-05-01 00:00:00
abstract::[This corrects the article on p. 878 in vol. 15, PMID: 25469103.]. ...
journal_title:Korean journal of radiology
pub_type: 已发布勘误
doi:10.3348/kjr.2015.16.1.217
更新日期:2015-01-01 00:00:00
abstract::Central diabetes insipidus (DI) can be the outcome of a number of diseases that affect the hypothalamic-neurohypophyseal axis. The causes of the condition can be classified as traumatic, inflammatory, or neoplastic. Traumatic causes include postoperative sella or transection of the pituitary stalk, while infectious or...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2001.2.4.222
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To evaluate spine magnetic resonance imaging (MRI) inter-reader and intra-reader reliabilities using the thoracolumbar injury classification system and severity score (TLICS) and to analyze the effects of reader experience on reliability and the possible reasons for discordant interpretations. MATERIALS AND ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.4.889
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To assess diffusion tensor imaging (DTI) parameters of the hepatic parenchyma for the differentiation of biliary atresia (BA) from Alagille syndrome (ALGS). MATERIALS AND METHODS:This study included 32 infants with BA and 12 infants with ALGS groups who had undergone DTI. Fractional anisotropy (FA) and mean ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2019.0824
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To assess magnetic resonance imaging (MRI) features of coronary microembolization in a swine model induced by small-sized microemboli, which may cause microinfarcts invisible to the naked eye. MATERIALS AND METHODS:Eleven pigs underwent intracoronary injection of small-sized microspheres (42 µm) and catheter...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2016.17.1.83
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:We wanted to evaluate the image quality, diagnostic accuracy and radiation exposure of 64-slice dual-source CT (DSCT) coronary angiography according to the heart rate in symptomatic patients during daily clinical practice. MATERIALS AND METHODS:We performed a retrospective search for the DSCT coronary angiog...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2011.12.3.308
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the feasibility of perfusion imaging of the brain using the Z-score and subtraction dynamic images obtained from susceptibility contrast MR images. MATERIALS AND METHODS:Five patients, each with a normal MRI, Moya-moya, a middle cerebral artery occlusion, post-trauma synd...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2004.5.3.143
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility of T2*-corrected fat-signal fraction (FF) map by using the three-echo volume interpolated breath-hold gradient echo (VIBE) Dixon sequence to differentiate between malignant marrow-replacing lesions and benign red marrow deposition of vertebrae. MATERIALS AND METHODS:We assessed 32 l...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.6.781
更新日期:2014-11-01 00:00:00
abstract::A narrow internal auditory canal (IAC) with duplication is a rare anomaly of the temporal bone. It is associated with congenital sensorineural hearing loss. Aplasia or hypoplasia of the vestibulocochlear nerve may cause the hearing loss. We present an unusual case of an isolated narrow IAC with duplication that was de...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.s.s22
更新日期:2008-07-01 00:00:00
abstract::Primary lymphoma of the uterus is a rare disease, the reported characteristic MR imaging findings being homogeneous intermediate signal intensity of the indistinct mass on T1- and T2-weighted images, and the preservation of endometrial lining and uterine architecture. We report a case of primary uterine lymphoma which...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2000.1.4.223
更新日期:2000-10-01 00:00:00
abstract::We present here the radiological findings of a rare case of multiple focal nodular hyperplasia that was associated with portal vein atresia and portopulmonary hypertension in a young woman. This case illustrates and supports the pathophysiological hypotheses that were previously proposed for the coexistence of these t...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.4.386
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the surgical morbidity and mortality of thoracic endovascular repair (TEVAR) as compared with open surgical repair (OSR) for isolated descending thoracic aortic disease. MATERIALS AND METHODS:From January 1, 2006 through May 31, 2010, a total of 68 patients with isolated descending...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.4.476
更新日期:2012-07-01 00:00:00
abstract::The Korean Society of Urogenital Radiology (KSUR) aimed to present a consensus statement for patient preparation, standard technique, and pain management in relation to transrectal ultrasound-guided prostate biopsy (TRUS-Bx) to reduce the variability in TRUS-Bx methodologies and suggest a nationwide guideline. The KSU...
journal_title:Korean journal of radiology
pub_type: 杂志文章,实务指引,评审
doi:10.3348/kjr.2019.0576
更新日期:2020-04-01 00:00:00
abstract::Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors. Distant metastasis of thymoma is very rare, and especially to extrathorcic areas. We report a female who had a metastatic thymoma in her breast 20 years after undergoing resection for a non-inv...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.1.80
更新日期:2008-01-01 00:00:00
abstract::The cystic lesions of the gastrointestinal (GI) tract demonstrate the various pathologic findings. Some lesions may present a diagnostic challenge because of non-specific imaging features; however, other lesions are easily diagnosed using characteristic radiologic features and anatomic locations. Cystic masses from th...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2010.11.4.457
更新日期:2010-07-01 00:00:00
abstract::The radiological appearance of diffuse discrete pulmonary nodules associated with cryptogenic organizing pneumonia (COP) has been rarely described. We describe a case of COP in 49-year-old woman with acute myeloid leukemia who developed diffuse pulmonary nodules during the second course of induction chemotherapy. The ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.1.93
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To compare the objective and subjective image quality indicators and radiation doses of computed tomography (CT) venography performed using model-based iterative reconstruction (MBIR) at 80 kVp and adaptive statistical iterative reconstruction (ASIR)-V at 70 kVp. MATERIALS AND METHODS:Eighty-three patients w...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.0897
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:The study aimed to describe portal stenting for postoperative portal occlusion with delayed (≥ 3 months) variceal bleeding in the afferent jejunal loop. MATERIALS AND METHODS:Eleven consecutive patients (age range, 2-79 years; eight men and three women) who underwent portal stenting between April 2009 and De...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.5.828
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To investigate the diagnostic performance of contrast-enhanced ultrasound (CEUS) and its role as a second-line imaging modality after gadoxetate-enhanced MRI (Gd-EOB-MRI) in the diagnosis of hepatocellular carcinoma (HCC) among at risk observations. MATERIALS AND METHODS:We prospectively enrolled participant...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2020.0973
更新日期:2020-11-03 00:00:00
abstract:Objective:To evaluate the current status of managing adverse reactions to iodinated contrast media (ICM) for computed tomography in referral hospitals in South Korea compared with hospitals in other countries. Materials and Methods:This survey investigation involved 59 Korean and 15 overseas hospitals using guideline-...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.0771
更新日期:2019-01-01 00:00:00