Update on Transarterial Chemoembolization with Drug-Eluting Microspheres for Hepatocellular Carcinoma.

Abstract:

:Conventional transcatheter arterial chemoembolization (c-TACE) is a widely used first-line palliative treatment for patients with unresectable hepatocellular carcinoma (HCC). Despite the effectiveness of c-TACE, to date, technique and procedure scheduling has not yet been standardized. Drug-eluting microspheres (DEMs) were therefore introduced to ensure more sustained and tumor-selective drug delivery for permanent embolization. These DEMs can load various drugs and release them in a sustained manner over a prolonged period. This approach ensures the delivery of high concentrations of chemotherapeutic agents to tumors, without increasing systemic concentrations, and promote tumor ischemia and necrosis. This review summarizes the recent advances in the use of DEM-TACE to treat HCC.

journal_name

Korean J Radiol

authors

Nouri YM,Kim JH,Yoon HK,Ko HK,Shin JH,Gwon DI

doi

10.3348/kjr.2018.0088

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

34-49

issue

1

eissn

1229-6929

issn

2005-8330

journal_volume

20

pub_type

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