Abstract:
OBJECTIVE:The purpose of the study was to non-invasively characterize and discriminate brown adipose tissue (BAT) from white adipose tissue (WAT) in rats using spectral computed tomography (CT) with histological validation. MATERIALS AND METHODS:A lipid-containing phantom (lipid fractions from 0% to 100%) was imaged with spectral CT. An in vivo, non-enhanced spectral CT scan was performed on 24 rats, and fat concentrations of BAT and WAT were measured. The rats were randomized to receive intraperitoneal treatment with norepinephrine (NE) (n = 12) or saline (n = 12). Non-enhanced and enhanced spectral CT scans were performed after treatment to measure the elevation of iodine in BAT and WAT. The BAT/aorta and WAT/aorta ratios were calculated and compared, after which isolated BAT and WAT samples were subjected to histological and uncoupling protein 1 (UCP1) analyses. RESULTS:The ex-vivo phantom study showed excellent linear fit between measured fat concentration and the known gravimetric reference standard (r² = 0.996). In vivo, BAT had significantly lower fat concentration than WAT (p < 0.001). Compared to the saline group, the iodine concentration of BAT increased significantly (p < 0.001) after injection of NE, while the iodine concentration of WAT only changed slightly. The BAT/aorta ratio also increased significantly after exposure to NE compared to the saline group (p < 0.001). Histological and UCP1 expression analyses supported the spectral CT imaging results. CONCLUSION:The study consolidates spectral CT as a new approach for non-invasive imaging of BAT and WAT. Quantitative analyses of BAT and WAT by spectral CT revealed different characteristics and pharmacologic activations in the two types of adipose tissue.
journal_name
Korean J Radioljournal_title
Korean journal of radiologyauthors
Peng XG,Zhao Z,Chang D,Bai Y,Xu Q,Ju Sdoi
10.3348/kjr.2019.0111subject
Has Abstractpub_date
2020-02-01 00:00:00pages
248-256issue
2eissn
1229-6929issn
2005-8330pii
21.248journal_volume
21pub_type
杂志文章abstract:OBJECTIVE:The aim of this work was to determine the radiation dose received by infants from radiographic exposure and the contribution from scatter radiation due to radiographic exposure of other infants in the same room. MATERIALS AND METHODS:We retrospectively evaluated the entrance skin doses (ESDs) and effective d...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.5.416
更新日期:2008-09-01 00:00:00
abstract::The radiological appearance of diffuse discrete pulmonary nodules associated with cryptogenic organizing pneumonia (COP) has been rarely described. We describe a case of COP in 49-year-old woman with acute myeloid leukemia who developed diffuse pulmonary nodules during the second course of induction chemotherapy. The ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.1.93
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the performance of diffusion tensor imaging (DTI) for the diagnosis of cervical spondylotic myelopathy (CSM) in patients with deformed spinal cord but otherwise unremarkable conventional magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS:A total of 33 patients who underwent MRI of the...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.6.1303
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Using a pulsating coronary artery phantom at high heart rate settings, we investigated the efficacy of a motion correction algorithm (MCA) to improve the image quality in dual-energy spectral coronary CT angiography (CCTA). MATERIALS AND METHODS:Coronary flow phantoms were scanned at heart rates of 60-100 be...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.6.881
更新日期:2017-11-01 00:00:00
abstract::Recent advances in computer technology have generated a new area of research known as radiomics. Radiomics is defined as the high throughput extraction and analysis of quantitative features from imaging data. Radiomic features provide information on the gray-scale patterns, inter-pixel relationships, as well as shape ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2019.0855
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:We evaluated the association between patients' weight and abdominal cross-sectional dimensions and CT image quality. MATERIALS AND METHODS:We prospectively evaluated 39 cancer patients aged more than 65 years with multislice CT scan of abdomen. All patients underwent equilibrium phase contrast-enhanced abdom...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2003.4.4.234
更新日期:2003-10-01 00:00:00
abstract::A 64-year-old male patient with liver cirrhosis underwent a CT study for hepatocellular carcinoma surveillance, which demonstrated a 1.4-cm hypervascular subcapsular tumor in the liver. On gadoxetic acid-enhanced MRI, the tumor showed brisk arterial enhancement and persistent hyperenhancement in the portal phase, but ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2013.14.5.769
更新日期:2013-09-01 00:00:00
abstract::Charcoal can be used for preoperative localization of metastatic lymph nodes in the neck. Charcoal remains stable without causing foreign body reactions during as hort period. However, foreign body reactions may develop if charcoal is left in situ for more than 6 months. We reported a case of charcoal granuloma mimick...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.1.196
更新日期:2015-01-01 00:00:00
abstract::Pancreatic surgery remains the only curative treatment for pancreatic neoplasms, and plays an important role in the management of medically intractable diseases. Since the original Whipple operation in the 20th century, surgical techniques have advanced, resulting in decreased postoperative complications and better cl...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2017.18.2.299
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:We wanted to evaluate the effectiveness of intraluminal irradiation with Holmium-166 ((166)Ho) for reducing the pseudointimal hyperplasia (PIH) in the transjugular intrahepatic portosystemic shunt (TIPS) tract in a swine model. MATERIALS AND METHODS:TIPS was performed in 12 domestic pigs, after the creation ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2007.8.2.127
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To evaluate urologist satisfaction on structured prostate MRI reports, including report with tumor-node-metastasis (TNM) staging (report B) and with Prostate Imaging Reporting and Data System (PI-RADS) score with/without TNM staging (report C, report with PI-RADS score only [report C-a] and report with PI-RAD...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2019.0820
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of Mangafodipir trisodium (Mn-DPDP)-enhanced MR cholangiogrphy (MRC) and Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRC in visualizing a non-dilated biliary system. MATERIALS AND METHODS:Eighty-eight healthy liver donor candidates underwent contrast-enhanced T1-weighted MRC. Mn-DPDP a...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2005.6.4.229
更新日期:2005-10-01 00:00:00
abstract::Multislice CT has been widely used in clinical practice for diagnosing cardiovascular disease due to its reduced invasiveness and its high spatial and temporal resolution. As a reliable alternative to conventional pulmonary angiography, multislice CT angiography has been recognized as the first line technique for dete...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.2.222
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To investigate the image quality (IQ) and apparent diffusion coefficient (ADC) of reduced field-of-view (FOV) di-ffusion-weighted imaging (DWI) of pancreas in comparison with full FOV DWI. MATERIALS AND METHODS:In this retrospective study, 2 readers independently performed qualitative analysis of full FOV DW...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2015.16.6.1216
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:We have used diffusion tensor tractography (DTT) for the evaluation of the somatotopic organization of corticospinal tracts (CSTs) in the posterior limb of the internal capsule (PLIC) and cerebral peduncle (CP). MATERIALS AND METHODS:We imaged the brains of nine healthy right-handed subjects. We used a spin-...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2008.9.3.191
更新日期:2008-05-01 00:00:00
abstract::The aim of this systematic review was to describe the characteristics of prostate-specific membrane antigen (PSMA)-targeting PET and their clinical applications in prostate cancer patients. There have been major strides in the design, synthesis of PSMA-targeting PET tracers over the past several years. PSMA-targeting ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.19.5.819
更新日期:2018-09-01 00:00:00
abstract::Imaging features of metastases to the urinary system may closely mimic primary urinary tract tumors, and differential diagnosis by imaging alone may be problematic or even impossible in some cases. The main purpose of this article was to familiarize radiologists with imaging findings of metastasis to the urinary syste...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2018.19.4.742
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To record the MR imaging features of primary central nervous system lymphoma (PCNSL) and compare these features in monofocal and multifocal disease. MATERIALS AND METHODS:Twenty-one cases of monofocal disease were compared to five cases of multifocal disease. All patients were examined by non-enhanced and co...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2010.11.3.269
更新日期:2010-05-01 00:00:00
abstract:Objective:To describe the clinical and ultrasonographic (US) findings in patients with scleredema adultorum of Buschke, who presented with sclerotic skin on their posterior neck. Materials and Methods:After obtaining IRB approval, eight patients with scleredema adultorum of Buschke were enrolled. They underwent US exa...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.19.3.425
更新日期:2018-05-01 00:00:00
abstract::The presence of myocardial ischemia is the most important prognostic factor in patients with ischemic heart disease. Fractional flow reserve (FFR) is a gold standard invasive method used to detect the stenosis-specific myocardial ischemia. FFR-guided revascularization strategy is superior to angiography-guided strateg...
journal_title:Korean journal of radiology
pub_type: 杂志文章,评审
doi:10.3348/kjr.2016.17.3.307
更新日期:2016-05-01 00:00:00
abstract::Diffuse esophageal leiomyomatosis is a rare benign tumor, which can be associated with leiomyoma in female genital tracts involving the uterus, vagina, and vulva. Alport syndrome, an inherited disorder that includes the kidneys, eyes, and sensorineural hearing loss, is also rarely associated with these multiple leiomy...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.6.632
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To determine the predictive factors for treatment responsiveness in patients with chronic obstructive pulmonary disease (COPD) at 1-year follow-up by performing quantitative analyses of baseline CT scans. MATERIALS AND METHODS:COPD patients (n = 226; 212 men, 14 women) were recruited from the Korean Obstruct...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2018.0204
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to describe MR findings of osteofibrous dysplasia. MATERIALS AND METHODS:MR images of 24 pathologically proven osteofibrous dysplasia cases were retrospectively analyzed for a signal intensity of the lesion, presence of intralesional fat signal, internal hypointense band, multilocul...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2014.15.1.114
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The objective of this retrospective study was to develop and validate a simple diagnostic prediction model by using ultrasound (US) features of thyroid nodules obtained from multicenter retrospective data. MATERIALS AND METHODS:Patient data were collected from 20 different institutions and the data included ...
journal_title:Korean journal of radiology
pub_type: 杂志文章,多中心研究
doi:10.3348/kjr.2013.14.1.110
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between apparent diffusion coefficient (ADC) values on diffusion-weighted magnetic resonance (MR) imaging and pathologic measures of a tumor using a prostate cancer xenograft model. MATERIALS AND METHODS:Eighteen athymic nude mice with 36 PC-3-induced tumors were sacrificed to obta...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.1.82
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This preliminarily study was designed to determine and to compare the efficacy of two commercially available barium-based fecal tagging agents for CT colonography (CTC) (high-density [40% w/v] and low-density [4.6% w/v] barium suspensions) in a population in Korea. MATERIALS AND METHODS:In a population with ...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2009.10.1.25
更新日期:2009-01-01 00:00:00
abstract::Chondrosarcomas are malignant tumors of cartilage that rarely involve the sinonasal region, and myxoid chondrosarcoma is a rare histologic variant of chondrosarcoma that usually occurs in the soft tissue of extremities. Although several case reports and results of small series of chondrosarcomas in the sinonasal regio...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2007.8.5.452
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of radiation dose and reconstruction algorithms on radiologists' preferences, and whether an iterative reconstruction in image space (IRIS) can be used for dose reduction in chest CT. MATERIALS AND METHODS:Standard dose chest CT (SDCT) in 50 patients and low dose chest CT (LDCT) in ano...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2012.13.6.720
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To compare the effect of radio frequency ablation (RFA) on the dimensions of radio frequency coagulation necrosis in a rabbit lung using a wet electrode in monopolar mode with that in dual electrode bipolar mode at different infusion rates (15 mm/hr versus 30 ml/hr) and saline concentrations (0.9% normal vers...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2006.7.2.97
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To describe radiologic findings of adenovirus pneumonia and to understand clinico-radiological features associated with progression to acute respiratory distress syndrome (ARDS) in patients with adenovirus pneumonia. MATERIALS AND METHODS:This study included 19 patients diagnosed with adenovirus pneumonia at...
journal_title:Korean journal of radiology
pub_type: 杂志文章
doi:10.3348/kjr.2016.17.6.940
更新日期:2016-11-01 00:00:00