Medulloblastoma-biology and microenvironment: a review.

Abstract:

:Medulloblastoma (MB) is a cancer of the cerebellum and the most common primary pediatric malignancy of the central nervous system. Classified as a primitive neural ectoderm tumor; it is thought to arise from granule cell precursors in the cerebellum. The standard of care consists of surgery, chemotherapy and age-dependent radiation therapy. Despite aggressive multimodality therapy; approximately 30% of MB patients remain incurable. Moreover, for long-term survivors, the treatment related sequelae are often debilitating. Side effects include cerebellar mutism, sterility, neurocognitive deficits, and a substantial risk of developing secondary cancers. In a quest for more effective and targeted therapies, scientists have begun to investigate the biological events that not only initiate but also sustain the malignant phenotype in MB. Of particular interest is, the role of the tumor microenvironment in tumor pathogenesis. This review seeks to highlight several key processes observed in cancer biology, particularly the involvement of the tumor microenvironment, with relevant examples from MB.

journal_name

Pediatr Hematol Oncol

authors

Byrd T,Grossman RG,Ahmed N

doi

10.3109/08880018.2012.698372

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

495-506

issue

6

eissn

0888-0018

issn

1521-0669

journal_volume

29

pub_type

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