Abstract:
UNLABELLED:Intravenous (IV) ferric iron (Fe)-carbohydrate complexes are used for treating Fe deficiency in children with iron-refractory iron-deficiency anemia (IRIDA). An optimal treatment has yet to be determined. There are relatively little publications on the responsiveness to IV iron therapy in children with IRIDA. PATIENTS AND METHOD:This study analyzed responses to IV iron sucrose therapy given to 11 children, ranging in age from 2 to 13 years (mean 4.8 years), with iron-deficiency anemia who were unresponsive to oral iron therapy. RESULTS:The hemoglobin and ferritin values (mean) of the 11 children with IRIDA were 7.7 g/dL and 4.8 ng/mL at diagnosis. Both hemoglobin and ferritin levels increased to 9.5 g/dL, and 24 ng/mL, respectively, at 6 weeks after the first therapy. Although the level of hemoglobin was steady at 6 months after the first, and 6 weeks after the second therapy, the ferritin levels continued to increase up to 30 ng/mL and 47 ng/mL at 6 months after the first and 6 weeks after the second therapy, respectively. CONCLUSION:We recommend that IRIDA should be considered in patients presenting with iron-deficiency anemia of unknown cause that is unresponsive to oral iron therapy. Our results suggest that IV iron therapy should be administered only once in cases of IRIDA. Continued administration of IV iron would be of no benefit to increase hemoglobin levels. On the contrary, ferritin levels may continue to increase resulting in untoward effects of hyperferritinemia.
journal_name
Pediatr Hematol Oncoljournal_title
Pediatric hematology and oncologyauthors
Akin M,Atay E,Oztekin O,Karadeniz C,Karakus YT,Yilmaz B,Erdogan Fdoi
10.3109/08880018.2013.829540subject
Has Abstractpub_date
2014-02-01 00:00:00pages
57-61issue
1eissn
0888-0018issn
1521-0669journal_volume
31pub_type
杂志文章abstract::To determine the effect of recombinant human granulocyte-colony stimulation factor (rhG-CSF) on the immune system, serum immunoglobulins, lymphocyte subsets, and serum cytokines were analyzed in eight pediatric patients with aplastic anemia (AA) during 8-week rhG-CSF therapy. The rhG-CSF was administered either subcut...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019409141675
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journal_title:Pediatric hematology and oncology
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doi:10.3109/08880018.2014.914112
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abstract::Primary immunodeficiency disorders (PID) are under-reported from the developing world. We present data regarding diagnosis and outcome from a hospital-based registry in India. Forty-seven patients fulfilled diagnostic criteria. Majority were males. Subgroups were disorders of immune dysregulation-29%, B&T-cell abnorma...
journal_title:Pediatric hematology and oncology
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abstract::Patterns of relapse were determined for 20 high-risk neuroblastoma patients treated with chemotherapy, surgery, primary and metastatic site radiation (21 Gray), myeloablative chemotherapy, peripheral blood stem cell rescue, and 13-cis-retinoic acid. The median follow-up duration after transplant is 21 months (range, 8...
journal_title:Pediatric hematology and oncology
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doi:
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abstract::Autologous blood-derived stem cells were used for stem-cell rescue in a 5-year-old boy with chemotherapy-resistant B-Non-Hodgkin's lymphoma (B-NHL) involving bone marrow. The high dose chemoradiotherapy was carried out 5 months after initial diagnosis during partial remission. The preparative regimen consisted of 12 G...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019009033383
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abstract::Homozygous beta-thalassemia is usually characterized by severe anemia requiring regular blood transfusion for survival. For homozygous patients with milder clinical manifestations and no dependence on transfusion therapy, the term thalassemia intermedia is usually applied. Genetic mechanisms that may ameliorate the cl...
journal_title:Pediatric hematology and oncology
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doi:10.3109/08880019509029526
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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abstract::A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...
journal_title:Pediatric hematology and oncology
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
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更新日期:2015-02-01 00:00:00
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/088800100276415
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章,评审
doi:10.1080/08880010600954397
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章,meta分析
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更新日期:2013-02-01 00:00:00
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journal_title:Pediatric hematology and oncology
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doi:10.3109/08880018709141261
更新日期:1987-01-01 00:00:00
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章
doi:10.1080/088800102753541323
更新日期:2002-04-01 00:00:00
abstract::Breastfeeding is well-known to have a protective effect against infection in infants. It has been suggested that breast milk may play a role in the prevention of certain childhood cancer. We investigated this issue in a case-control study comprising 300 patients with childhood cancer. There was 73 patients (24.3%) wit...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was disco...
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journal_title:Pediatric hematology and oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2004-01-01 00:00:00
abstract::Olfactory neuroblastoma, a rare malignancy of the olfactory epithelium, is an uncommon tumor in children. It occurs mostly in older individuals and the treatment strategies are based on the experience with adults. In this report, clinical characteristics and treatment results of 2 patients with olfactory neuroblastoma...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880018.2010.514656
更新日期:2011-02-01 00:00:00
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章,评审
doi:10.3109/08880019809014013
更新日期:1998-07-01 00:00:00
abstract::A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. Its precursor peptide form is called pro-hepcidin. The aims of this study were to determine serum ...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010600629213
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abstract::The aim of this study was to evaluate children with lymphadenopathy and clinical approach to the suspicion of malignancy. The authors evaluated 457 patients with peripheral lymphadenopathy, less than 19 years of age, and referred to the Pediatric Oncology Department of Gazi University Medical School during the periods...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880010600856907
更新日期:2006-10-01 00:00:00
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/08880018.2019.1699213
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journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/088800101753328475
更新日期:2001-12-01 00:00:00
abstract::In this paper we describe a 9-year-old girl with abdominal embryonal rhabdomyosarcoma. She had ascites and widespread metastatic disease at presentation and was oliguric but had a normal creatinine. Following the start of chemotherapy she developed acute renal failure secondary to the tumor lysis syndrome, requiring h...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.3109/08880019309016549
更新日期:1993-04-01 00:00:00
abstract::Growth hormone deficiency (GHD) is a recognized late effect of successful treatment of tumors requiring cranial irradiation. Growth after treatment was assessed in 16 patients with sarcomas of the orbital and parameningeal regions. Median age at diagnosis was 6.35 years and median follow-up was 7.2 years. Treatment co...
journal_title:Pediatric hematology and oncology
pub_type: 杂志文章
doi:10.1080/088800199277560
更新日期:1999-01-01 00:00:00