Relapse in the skull after myeloablative therapy for high-risk neuroblastoma.

Abstract:

:Patterns of relapse were determined for 20 high-risk neuroblastoma patients treated with chemotherapy, surgery, primary and metastatic site radiation (21 Gray), myeloablative chemotherapy, peripheral blood stem cell rescue, and 13-cis-retinoic acid. The median follow-up duration after transplant is 21 months (range, 8-34 months). The event-free survival and overall survival at 2 years were 45 and 75%, respectively. There were 2 primary site recurrences. Metastatic sites that became MIBG-scan negative on induction chemotherapy were not irradiated. Four patients relapsed in irradiated metastatic sites, 3 in the skull, 1 in the liver. Failure also occurred at 2 skull sites treated with chemotherapy only, and at 5 new sites: 1 skull, 2 distant lymph nodes, and 2 bones other than skull. Eight of 20 patients had skull metastasis at presentation; 6 were irradiated and 3 were controlled. Skull metastasis warrants more aggressive evaluation and treatment.

journal_name

Pediatr Hematol Oncol

authors

Sangthawan D,DesRosiers PM,Randall ME,Robertson K,Goebel S,Fallon R

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

23-30

issue

1

eissn

0888-0018

issn

1521-0669

journal_volume

20

pub_type

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