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Nerve cell response to inhibitors recorded with an aluminum-galliumnitride/galliumnitride field-effect transistor.

Abstract：

:Experiments based on neuronal cell-transistor couplings were made from some groups during the last years. Pioneering work in this field was carried out by Fromherz and his group (Fromherz, 2003; Schmidtner and Fromherz, 2006). We were interested of the interaction of nerve cells to serine hydrolase inhibitor diisopropylfluorophosphate (DFP), monitored by using an aluminum-galliumnitride/galliumnitride (AlGaN/GaN) electrolyte gate field effect transistor (EGFET). The biocompatibility study of our sensor materials with nerve cells shows a proliferation rate of at least 95%. The inhibitors were added to the medium and the source-drain current of the EGFET was recorded as a function of time. The inhibitor was added to the NG108-15 nerve cells growing directly on the sensor surface, resulting in a fast decrease in the drain current, I(DS). Control measurements show that this response is associated with cationic fluxes pumped through ionic channels present in the cellular membrane. The sensor enables analysis of the ion channel activity without cell destruction and simultaneously allows visual observation due to the optical transparency of the sensor material.

journal_name

J Neurosci Methods

journal_title

Journal of neuroscience methods

authors

Gebinoga M,Mai P,Donahue M,Kittler M,Cimalla I,Lübbers B,Klett M,Lebedev V,Silveira L,Singh S,Schober A

doi

10.1016/j.jneumeth.2012.02.018

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

195-9

issue

2

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(12)00063-5

journal_volume

206

pub_type

杂志文章

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