Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection.

Abstract:

:sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS.

journal_name

Acta Neurol Scand

authors

Alvarez-Cermeño JC,Casado C,Villar LM,Ferreira A,Varela JM,Dominguez M,Bootello A,Najera R,Gonzalez-Porque P

doi

10.1111/j.1600-0404.1990.tb01580.x

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

14-6

issue

1

eissn

0001-6314

issn

1600-0404

journal_volume

82

pub_type

杂志文章
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    doi:

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