Intrathecal interferon in subacute sclerosing panencephalitis.

Abstract:

:Three patients at Stage II of subacute sclerosing panencephalitis (SSPE) were treated with semipurified alpha-interferon (IFN) using different combinations of intrathecal and intravenous routes: 1 x 10(6) IU of alpha-IFN were given every other day up to a total of 15 x 10(6) IU. Transient improvement of neurological symptoms and electroencephalogram were noted in all 3, while cognitive function slightly improved in 2 of them. Clinical benefits gradually disappeared 2 to 6 months after cessation of IFN. Intrathecal antibody production did not change substantially, but CSF Leu 3a/Leu 2a ratio appeared to increase. No significant side effects were observed, except for a mild meningeal inflammatory reaction after each intrathecal administration of IFN.

journal_name

Acta Neurol Scand

authors

Maimone D,Grimaldi LM,Incorpora G,Biondi R,Sofia V,Mancuso GR,Siciliano L,Ruscica M,Pavone L

doi

10.1111/j.1600-0404.1988.tb03639.x

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

161-6

issue

3

eissn

0001-6314

issn

1600-0404

journal_volume

78

pub_type

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