Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study.

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a group of intestinal disorders characterised by chronic relapsing inflammation of the small intestine and colon. IBD manifests as either ulcerative colitis or Crohn's disease and increases the risk of developing colorectal cancer. METHODS:Here, we have reviewed current t...

journal_title：Current pharmaceutical design

authors： Perera AP,Kunde D,Eri R

更新日期：2017-01-01 00:00:00

abstract：:The prevalence of fungal infections of skin has increased rapidly, affecting approximately 40 million people across the globe. A wide variety of antifungal drugs has been utilized in the effective management of numerous dermatological infections. Topical treatment of fungal infections has proved to be quite advantageo...

journal_title：Current pharmaceutical design

authors： Akhtar N,Verma A,Pathak K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive impairment, including intellectual disability, autism, hyperactivity, and epilepsy. METHODS:This article reviews the literature pertaining to the role of synaptic dysfunction in FXS. RESULTS:In FXS, synaptic dysfunction alte...

journal_title：Current pharmaceutical design

authors： Telias M

更新日期：2019-01-01 00:00:00

abstract：:Gene delivery, a process of introducing foreign functional nucleic acids into target cells, has proven to be a very promising tool for inducing specific gene expression in host cells. Many different technologies have been developed for efficient gene delivery. Among them, electroporation has been adopted in gene deliv...

journal_title：Current pharmaceutical design

authors： Yang Z,Chang L,Chiang CL,Lee LJ

更新日期：2015-01-01 00:00:00

abstract：:Radiolabelled peptides and monoclonal antibodies are an emerging class of radiopharmaceuticals for imaging inflammation with clinical implications for several chronic inflammatory disorders for diagnosis, therapy decision making and follow up. In the last decades, a number of novel monoclonal antibodies and peptides h...

journal_title：Current pharmaceutical design

authors： Malviya G,Signore A,Laganà B,Dierckx RA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Reversible cholinesterase inhibitors, when given prophylactically before exposure to organophosphates, are able to decrease organophosphate-induced mortality. However, the efficacy of pyridostigmine, the only pre-treatment substance approved by the US Federal Drug Administration, is unsatisfactory. METHODS:...

journal_title：Current pharmaceutical design

authors： Lorke DE,Nurulain SM,Hasan MY,Kuca K,Petroianu GA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials. OBJECTIVE:The aim ...

journal_title：Current pharmaceutical design

authors： Guo Y,Chen B,Pei X,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution. Present formulations consists of 1% or 2% (w/v) propofol, ...

journal_title：Current pharmaceutical design

authors： Marik PE

更新日期：2004-01-01 00:00:00

abstract：:Systemic hypersensitivity (HS) to corticosteroids (CS) is paradoxical but does exist. Some patients with a previous contact allergy to topical CS may develop a systemic contact dermatitis (SCD) while receiving CS orally or intravenously. However, a previous contact sensitization is not mandatory for developing a syste...

journal_title：Current pharmaceutical design

authors： Barbaud A,Waton J

更新日期：2016-01-01 00:00:00

abstract：:The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in particular aimed towards gene silencing applications. The common methods of synthesis of oligonucleotide-peptide conjugates (OPCs) and PNA-peptide conjugates (PP...

journal_title：Current pharmaceutical design

authors： Zatsepin TS,Turner JJ,Oretskaya TS,Gait MJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Carbon dioxide (CO2) exists in nature around us. In the middle of the 20th century, the intraluminal injection of CO2 demonstrated similar results to those of Digital Subtraction Angiography (DSA) with an iodinated contrast agent (ICA). Since then, the technology behind CO2 DSA has developed significantly. ...

journal_title：Current pharmaceutical design

authors： Patelis N,Doulaptsis M,Kykalos S,Spartalis E,Maskanakis A,Georgopoulos S

更新日期：2019-01-01 00:00:00

abstract：:Tocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein ...

journal_title：Current pharmaceutical design

authors： Catalgol B,Batirel S,Ozer NK

更新日期：2011-01-01 00:00:00

abstract：:Adenosine triphosphate (ATP) synthase produces ATP in cells and is found on the inner membrane of mitochondria or the cell plasma membrane (ectopic ATP synthase). Here, we summarize the functions of ectopic ATP synthase in vascular endothelial cells (ECs). Ectopic ATP synthase is involved in adenosine metabolism on th...

journal_title：Current pharmaceutical design

authors： Fu Y,Zhu Y

更新日期：2010-01-01 00:00:00

abstract：:This article reviews evidence that hyperpolarization-activated, cation nonselective (HCN) channels, the molecular basis of the Ih current, potentially represent valid targets for novel analgesic agents. Ih is a prominent current in many peripheral sensory nerves, with highest current density typically found in large d...

journal_title：Current pharmaceutical design

authors： Wickenden AD,Maher MP,Chaplan SR

更新日期：2009-01-01 00:00:00

abstract：:Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate...

journal_title：Current pharmaceutical design

authors： Ishii M,Kurachi Y

更新日期：2006-01-01 00:00:00

abstract：:Locomotion is one of the most complex motor behaviors. Locomotor patterns change during early life, reflecting development of numerous peripheral and hierarchically organized central structures. Among them, the spinal cord is of particular interest since it houses the central pattern generator (CPG) for locomotion. Th...

journal_title：Current pharmaceutical design

authors： Brumley MR,Guertin PA,Taccola G

更新日期：2017-01-01 00:00:00

abstract：:The solid lipid nanoparticles (SLNs) usually consists of active drug molecules along with solid lipids, surfactants, and/or co-surfactants. They possess some potential features such as nano-size, surface with a free functional group to attach ligands, and as well they prove safe homing for both lipophilic as well as h...

journal_title：Current pharmaceutical design

authors： Rajpoot K

更新日期：2019-01-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Arterial hypertension (AH) and peripheral arterial disease (PAD) frequently coincide. While significant attention is paid to AH, PAD is often underestimated. It is known that both AH and PAD present high cardiovascular risks for ischemic events. To date, the use of the most common anti-hypertensive drugs in ...

journal_title：Current pharmaceutical design

authors： Signorelli SS

更新日期：2017-01-01 00:00:00

abstract：:Osteoblasts pass through a sequence of events controlled by hormones and transcriptional factors ensuring proper development of phenotype and functional properties until the osteoblast enter the osteocyte phenotype and/or undergo apoptosis. During its life cycle, the osteoblasts proliferate, deposit matrix proteins an...

journal_title：Current pharmaceutical design

authors： Gordeladze JO,Reseland JE,Drevon CA

更新日期：2001-03-01 00:00:00

abstract：:Senescence is defined as an irreversible growth arrest that is characterised by a changed morphology, gene expression pattern and chromatin structure as well as an activated DNA damage response. Senescence has a dual role for tumour development-it acts as a tumour suppressor to prevent the proliferation of seriously d...

journal_title：Current pharmaceutical design

authors： Saretzki G

更新日期：2010-01-01 00:00:00

abstract：:In recent years several new drugs (oxcarbazepine, lamotrigine, topiramate, gabapentin, zonisamide, tiagabine, fosphenytoin, vigabatrin and felbamate) have been added to the therapeutic armamentarium against epilepsy. Some of these represent structural modifications of pre-existing compounds, others were developed with...

journal_title：Current pharmaceutical design

authors： Gatti G,Bonomi I,Jannuzzi G,Perucca E

更新日期：2000-05-01 00:00:00

abstract：:Melanoma is the deadliest type of skin cancers, accounting for more than 80% of skin cancer mortality. Although melanoma was known very early in the history of medicine, treatment for this disease had remained largely the same until very recently. Previous treatment options, including removal surgery and systemic chem...

journal_title：Current pharmaceutical design

authors： Tran KB,Buchanan CM,Shepherd PR

更新日期：2020-01-01 00:00:00

abstract：:The skin is often introduced as the largest organ of the human body which - being uniquely exposed to external stress - faces several types of challenges, from physical, chemical, biological, and immunological origin. Therefore, the skin is also a site where inflammation, oxidative stress and cellular damage occurs re...

journal_title：Current pharmaceutical design

authors： Szabo IL,Kenyeres A,Szegedi A,Szollosi AG

更新日期：2018-01-01 00:00:00

abstract：:Agitation is commonly seen in acute schizophrenic patients and core symptoms include a wide range of symptom. It requires rapid and effective treatment approaches in order to protect patient and caregiver from potential injury. Clinician's decision of pharmacological treatment should be individualized to the needs and...

journal_title：Current pharmaceutical design

authors： San L,Arranz B,Escobar R

更新日期：2005-01-01 00:00:00

abstract：:Viral infections are important causes of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. Some viruses, such as the respiratory and gastrointestinal viruses, are acquired from the healthcare or community in the midst of or after HSCT. Other viruses, such as the herpes-virus family, esta...

journal_title：Current pharmaceutical design

authors： Anderson EJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:On a tide of big data, machine learning is coming to its day. Referring to huge amounts of epigenetic data coming from biological experiments and clinic, machine learning can help in detecting epigenetic features in genome, finding correlations between phenotypes and modifications in histone or genes, accele...

journal_title：Current pharmaceutical design

authors： Fan S,Chen Y,Luo C,Meng F

更新日期：2018-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic relapsing conditions resulting from immune system activity in a genetically predisposed individual. IBD is based on progressive damage to the inflamed gut tissue. As its pathogenesis remains unknown, recent accumu...

journal_title：Current pharmaceutical design

authors： Alimohammadi N,Koosha F,Rafeian-Kopaei M

更新日期：2020-01-01 00:00:00

abstract：:Neglected parasitic diseases are a group of infections currently considered as a worldwide concern. This fact can be attributed to the migration of these diseases to developed and developing countries, associated with therapeutic insufficiency resulted from the low investment in the research and development of new dru...

journal_title：Current pharmaceutical design

authors： Albino SL,da Silva JM,de C Nobre MS,de M E Silva YMS,Santos MB,de Araújo RSA,do C A de Lima M,Schmitt M,de Moura RO

更新日期：2020-01-01 00:00:00

abstract：:DARPins (designed ankyrin repeat proteins), new kinds of binding proteins, have the potential to overcome the defects of monoclonal antibodies, and hence may become the alternatives to antibodies and generate a novel therapeutic approach. DARPins can be selected to bind any given target proteins with high affinity and...

journal_title：Current pharmaceutical design

authors： Wu X,Shi Y,Ren P,Wang D,Li G

更新日期：2013-01-01 00:00:00