Heme Oxygenase and the Skin in Health and Disease.

abstract：:Prostacyclin (PGI(2)) is one of the major vascular protectors against thrombosis and vasoconstriction, caused by thromboxane A(2). Understanding the molecular mechanisms of PGI(2) biosynthesis and signaling is crucial to the development of therapeutic approaches to regulate PGI(2) functions. This review provides infor...

journal_title：Current pharmaceutical design

authors： Ruan KH,Dogné JM

更新日期：2006-01-01 00:00:00

abstract：:Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random p...

journal_title：Current pharmaceutical design

authors： Čejková J,Štêpánek F

更新日期：2013-01-01 00:00:00

abstract：:G protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-...

journal_title：Current pharmaceutical design

authors： Ciccarelli M,Cipolletta E,Iaccarino G

更新日期：2012-01-01 00:00:00

abstract：:Protein stability of hypoxia-inducible factor (HIF)alpha subunits is regulated by the oxygen-sensing prolyl-4-hydroxylase domain (PHD) enzymes. Under oxygen-limited conditions, HIFalpha subunits are stabilized and form active HIF transcription factors that induce a large number of genes involved in adaptation to hypox...

journal_title：Current pharmaceutical design

authors： Wenger RH,Camenisch G,Stiehl DP,Katschinski DM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development. METHODS:The presented article will provide an overview on...

journal_title：Current pharmaceutical design

authors： Peters FT,Wissenbach DK,Busardo FP,Marchei E,Pichini S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Multi-drug resistant infections are a growing worldwide health concern. There is an urgent need to produce alternative antimicrobial agents. OBJECTIVE:The study aimed to design a new hybrid antimicrobial peptide, and to evaluate its antimicrobial activity alone and in combination with traditional antibiotic...

journal_title：Current pharmaceutical design

authors： Tall YA,Al-Rawashdeh B,Abualhaijaa A,Almaaytah A,Masadeh M,Alzoubi KH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities...

journal_title：Current pharmaceutical design

authors： Irshad I,Varamini P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Dietary supplements have been widely used among the United States of America (USA) and the European Union (EU) population not only as a form of nutrition but also for medicinal purposes. Still, the legislation regulating these supplements remains unclear due to the fact that they can be considered as foodstu...

journal_title：Current pharmaceutical design

authors： Pereira C,Barros L,Ferreira ICFR

更新日期：2017-01-01 00:00:00

abstract：:Angiogenesis is regulated by stimulators and inhibitors and involve multiple biological processes including endothelial cell proliferation, migration, cell-cell and cell-matrix adhesion, assembly into tube structures as well as apoptosis. Designing and developing peptides for therapeutic application to inhibit angioge...

journal_title：Current pharmaceutical design

authors： Sulochana KN,Ge R

更新日期：2007-01-01 00:00:00

abstract：:Heat shock proteins (HSPs) are involved in a number of cellular processes, including cell cycle, growth, and survival, apoptosis, stress responses, angiogenesis, and oncogenesis. Among the characterized HSPs, the molecular chaperone HSP90 has emerged as an exciting molecular target for cancer therapy since its discove...

journal_title：Current pharmaceutical design

authors： Kondoh Y,Osada H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel chalcone analogs, small organic molecules, to investigate their effects on KRAS-mutant CRC cells. MET...

journal_title：Current pharmaceutical design

authors： Mahmoud A,Elkhalifa D,Alali F,Al Moustafa AE,Khalil A

更新日期：2020-01-01 00:00:00

abstract：:Prevention, improved screening, and better treatment regimens have improved cancer incidence and mortality in the last decade. Chemoradiation continues to cause high morbidity in patients undergoing treatment. DNA therapeutics have the potential to modify the genes that cause tumor progression in order to produce a re...

journal_title：Current pharmaceutical design

authors： Coppelli FM,Grandis JR

更新日期：2005-01-01 00:00:00

abstract：:Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. Th...

journal_title：Current pharmaceutical design

authors： Capuron L,Geisler S,Kurz K,Leblhuber F,Sperner-Unterweger B,Fuchs D

更新日期：2014-01-01 00:00:00

abstract：:Monocytes are leading component of the mononuclear phagocytic system that play a key role in phagocytosis and removal of several kinds of microbes from the body. Monocytes are bone marrow precursor cells that stay in the blood for a few days and migrate towards tissues where they differentiate into macrophages. Monocy...

journal_title：Current pharmaceutical design

authors： Sabir F,Farooq RK,Asim Ur Rehman,Ahmed N

更新日期：2018-01-01 00:00:00

abstract：:The diatomic molecule of oxygen contains two uncoupled electrons and can therefore undergo reduction, yielding several different oxygen metabolites, which are collectively called Reactive Oxygen Species or ROS. They are invariably produced in aerobic environments through a variety of mechanisms, which include electron...

journal_title：Current pharmaceutical design

authors： Bergamini CM,Gambetti S,Dondi A,Cervellati C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:In Alzheimer's disease (AD), modification of astrocytic properties is a well-known and documented fact, but their involvement in pathophysiology has only been examined in recent years. One distinct hallmark of AD is reactive gliosis which are represented in microglial and astrocytic phenotype changes. This r...

journal_title：Current pharmaceutical design

authors： Yi C,Koulakoff A,Giaume C

更新日期：2017-01-01 00:00:00

abstract：:The organ shortage for kidney transplantation remains a challenging issue worldwide. Incompatibility between donor-recipient pairs, commonly occurring among transplant candidates who were sensitized from prior antigen exposure, serves as a significant barrier to kidney transplantation. In efforts to overcome this obst...

journal_title：Current pharmaceutical design

authors： Mustian MN,Locke JE

更新日期：2020-01-01 00:00:00

abstract：:Multiple molecular, cellular, structural and functional changes occur in the brain during aging. Neural cells may respond to these changes adaptively by employing multiple mechanisms in order to maintain the integrity of nerve cell circuits and to facilitate responses to environmental demands. Otherwise, they may succ...

journal_title：Current pharmaceutical design

authors： Lanni C,Stanga S,Racchi M,Govoni S

更新日期：2010-01-01 00:00:00

abstract：:Cardiovascular disease (CVD) is one of the major lifestyle associated disorders and leading causes of death worldwide. The incidence of CVD in diabetic patients has increased up to 3 folds and it became the major risk for diabetes associated morbidity and mortality. Insulin resistance and oxidative stress both play a ...

journal_title：Current pharmaceutical design

authors： Bagul PK,Banerjee SK

更新日期：2013-01-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) are components of most current antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced by these drugs is a common reason why patients treated with NRTI change or discontinue therapy. These toxicities can be difficult to reverse, ...

journal_title：Current pharmaceutical design

authors： Feeney ER,Mallon PW

更新日期：2010-10-01 00:00:00

abstract：:The intestinal epithelium forms a barrier against the intestinal contents and the wider environment, allowing entry of selected molecules for nutrition and programming of the mucosal immune system, but excluding toxins and most microorganisms. Many receptors and signalling pathways are coupled and implicated in the ep...

journal_title：Current pharmaceutical design

authors： Talero E,Garcia-Maurino S,Motilva V

更新日期：2014-01-01 00:00:00

abstract：:The survival of patients with pulmonary arterial hypertension is closely related with right ventricular function. During the progression of right ventricular remodeling, energetic metabolism shifts from oxidative mitochondrial metabolism to glycolysis. In normal physiological conditions, cardiomyocytes use major sourc...

journal_title：Current pharmaceutical design

authors： Zhang R,Jing ZC

更新日期：2016-01-01 00:00:00

abstract：:Aspirin has been one of the most widely used medications since its first synthesis more than 100 years ago. In addition to short-term use for pain and fever relief, regular use of aspirin has been shown to reduce the risk of cardiovascular diseases and strokes. The issue of regular aspirin use in cancer prevention is ...

journal_title：Current pharmaceutical design

authors： Huang WK,Tu HT,See LC

更新日期：2015-01-01 00:00:00

abstract：:In various metabolic diseases, both the coronary circulation and cardiac metabolism are altered. Here we summarize the effects of a condition called hyperhomocysteinemia (HHcy) - which can develop due to genetic and/or environmental causes - on the function of coronary microvessels and heart. This metabolic disease is...

journal_title：Current pharmaceutical design

authors： Koller A,Szenasi A,Dornyei G,Kovacs N,Lelbach A,Kovacs I

更新日期：2018-01-01 00:00:00

abstract：:Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) transduce their mitogenic signals through the activation of tyrosine kinase receptors (RTKs). Since en...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Sachinidis A

更新日期：2004-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical design

authors： Deb PK

更新日期：2019-01-01 00:00:00

abstract：:Many therapeutically active medications have significant side effects, some of which can compromise the intended therapeutic goal. The development of plasma lipid abnormalities or a dyslipidemia as the result of a medication intended for an unrelated effect has been reported. Human immunodeficiency virus (HIV) infecti...

journal_title：Current pharmaceutical design

authors： Whayne TF,Mukherjee D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The last few decades have witnessed enormous advancements in the field of Pharmaceutical drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medica...

journal_title：Current pharmaceutical design

authors： Mirza MA,Iqbal Z

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway. METHODS:A chimeric...

journal_title：Current pharmaceutical design

authors： Khosravi M,Kakavandi N,Rezaee S,Shabani M,Najafi M

更新日期：2020-01-01 00:00:00

abstract：:The search for methods to control physiological levels of carbon monoxide (CO), a vasoactive molecule, and bilibrubin, an antioxidant, have improved our understanding of the protective role of heme oxygenase (HO) against oxidative injury. HO activity can assist other antioxidant systems in diminishing the overall prod...

journal_title：Current pharmaceutical design

authors： Abraham NG

更新日期：2003-01-01 00:00:00