Cellular senescence in the development and treatment of cancer.

abstract：BACKGROUND:Erectile dysfunction (ED) is an evolving health problem in the aging male population. Chronic low-grade inflammation is a critical component of ED pathogenesis and a probable intermediate stage of endothelial dysfunction, especially in metabolic diseases, with the inclusion of obesity, metabolic syndrome, an...

journal_title：Current pharmaceutical design

authors： Kaya-Sezginer E,Gur S

更新日期：2020-01-01 00:00:00

abstract：:Following injury, as part of the wound-healing process, cell proliferation occurs mostly to replace damaged cells and to reconstitute the tissue back to normal condition/function. In the spinal cord some of the dividing cells following injury interfere with the repair processes. This interference occurs at the later s...

journal_title：Current pharmaceutical design

authors： Kalderon N

更新日期：2005-01-01 00:00:00

abstract：:While it is well documented that the mitogenic actions of estrogens are critical in the development and progression of human breast and some gynecologic cancers, only latest data demonstrate a crucial involvement of estrogen-signaling in the carcinogenesis of non-classical estrogen target tissues, as colon, prostate, ...

journal_title：Current pharmaceutical design

authors： Gallo D,De Stefano I,Grazia Prisco M,Scambia G,Ferrandina G

更新日期：2012-01-01 00:00:00

abstract：:Hyperferritinemia is observed in one-third of patients with non-alcoholic fatty liver disease (NAFLD) and Metabolic Syndrome (MetS). The condition characterized by increased body iron stores associated with components of MetS has been defined as Dysmetabolic Iron Overload Syndrome (DIOS). DIOS represents the most freq...

journal_title：Current pharmaceutical design

authors： Rametta R,Fracanzani AL,Fargion S,Dongiovanni P

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnes...

journal_title：Current pharmaceutical design

authors： Giglio RV,Patti AM,Cicero AFG,Lippi G,Rizzo M,Toth PP,Banach M

更新日期：2018-01-01 00:00:00

abstract：:Approximately half of patients with schizophrenia have a lifetime diagnosis of substance abuse disorders. These dual diagnosis patients are more likely to have poorer outcomes, including more severe psychiatric symptoms with increased hospitalizations, higher utilization of services and frequent homelessness. Assessme...

journal_title：Current pharmaceutical design

authors： Tsuang J,Fong TW

更新日期：2004-01-01 00:00:00

abstract：:In recent years, new strategies in cancer therapy have been developed targeting key signaling molecules in the receptor tyrosine kinase signal transduction pathway. In contrast, most therapeutical concepts to manipulate G protein-coupled receptors (GPCR)-mediated disorders are still limited to the use of receptor-spec...

journal_title：Current pharmaceutical design

authors： Liebmann C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Lipid nanoparticles have attracted increased degree of scientific and commercial attention in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems due to their various advantages over them and also due to overcoming the shortcomings of the already ava...

journal_title：Current pharmaceutical design

authors： Pathak K,Shankar R,Joshi M

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Pulmonary diseases are the third leading cause of morbidity worldwide, however treatment and diagnosis of these diseases continue to be challenging due to the complex anatomical structure as well as physiological processes in the lungs. METHODS:3D printing is progressively finding new avenues in the medical...

journal_title：Current pharmaceutical design

authors： Haque S,Md S,Whittaker M,Kaminskas LM

更新日期：2018-01-01 00:00:00

abstract：:The discovery of the delicate role of endogenous nitric oxide in the homeostasis of various cellular functions and the dynamic behaviour of the airways, has led to a new, rapidly progressing area of physiological science, that has direct bearing for our understanding of multiple airway diseases. The potentially protec...

journal_title：Current pharmaceutical design

authors： Folkerts G,Nijkamp FP

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cancer is the world's second-largest cause of death, with an estimated 9.6 million fatalities in 2018. Malignant tumour (cancer) is caused by a mixture of genetic modifications due to the environmental variables that tend to activate or inactivate different genes, ultimately resulting in neoplastic transform...

journal_title：Current pharmaceutical design

authors： Jindal M,Nagpal M,Singh M,Aggarwal G,Dhingra GA

更新日期：2020-01-01 00:00:00

abstract：:It is well known that heat shock proteins (HSPs) are induced by various stressors in order to confer protection against such stressors. Since stressor-induced tissue damage is involved in various diseases, especially gastrointestinal diseases, such as gastric ulcer, it has been thought that HSPs are protective against...

journal_title：Current pharmaceutical design

authors： Mizushima T

更新日期：2010-01-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：:Severe sepsis leading to shock is the principal cause of death in intensive care units. It is a systemic inflammatory response caused by excessive secretion of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNFalpha) and reactive oxygen species (ROS), mainly induced by endotoxin (a major component of...

journal_title：Current pharmaceutical design

authors： Victor VM,Rocha M,Esplugues JV,De la Fuente M

更新日期：2005-01-01 00:00:00

abstract：:Effective blood pressure control with a large arsenal of conventional antihypertensive drugs, such as diuretics, beta-adrenergic blockers, and calcium channel blockers, significantly reduce the morbidity and mortality associated with cardiovascular disease. However, blood pressure control with these drugs does not red...

journal_title：Current pharmaceutical design

authors： Igic R,Behnia R

更新日期：2007-01-01 00:00:00

abstract：:Carboxylic acids are an important natural component as a final product or intermediates for syntheses. They are produced in plants, animals and also as products from biotechnological processes. This review presents the use of single hydroxide particles and layered double hydroxides as alternative adsorbents to remove ...

journal_title：Current pharmaceutical design

authors： Rodriguez LEG,Bail A,Castillo RO,Arízaga GGC

更新日期：2020-01-01 00:00:00

abstract：:Single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, mainly because escape or resistance mechanisms are activated once a signalling molecule is inhibited. Rational combinations of target-specific agents could counteract this response providing a useful strategy in ca...

journal_title：Current pharmaceutical design

authors： Porcelli L,Quatrale AE,Mantuano P,Silvestris N,Rolland JF,Biancolillo L,Paradiso A,Azzariti A

更新日期：2013-01-01 00:00:00

abstract：:Aspirin is an antiplatelet drug, inhibiting the cyclooxygenase activity of platelet prostaglandin H synthase-1 and almost complete suppressing platelet capacity to generate the prothrombotic and proatherogenic thromboxane A2. Antiplatelet therapy with aspirin reduces the risk of serious vascular events by about a quar...

journal_title：Current pharmaceutical design

authors： De Caterina R,Renda G

更新日期：2012-01-01 00:00:00

abstract：:Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs)...

journal_title：Current pharmaceutical design

authors： Tu C,He J,Chen R,Li Z

更新日期：2019-01-01 00:00:00

abstract：:Chloride channels play important roles in vital cellular signalling processes contributing to homeostasis in both excitable and non-excitable cells. Since 1987, more than ten ion channel genes have been identified as causing human hereditary diseases among them the genes for the voltage-dependent chloride channel ClC-...

journal_title：Current pharmaceutical design

authors： Becq F

更新日期：2006-01-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II transcription. Several pharmacological CDK inhibitors (PCIs) are currently in clinical trials as potential cancer therapeutics since CDK hyperactivation is detected in the majority of neoplasias. Within the last few years, the a...

journal_title：Current pharmaceutical design

authors： Pumfery A,de la Fuente C,Berro R,Nekhai S,Kashanchi F,Chao SH

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addres...

journal_title：Current pharmaceutical design

authors： Sinaei F,Emami SA,Sahebkar A,Javadi B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) has high mortality partly due to acquiring drug resistance during chemotherapy treatment. Therefore, it is necessary to explore the underlying mechanism of drug resistance. METHODS:We used 2-DE and MALDI-TOF-MS analysis to explore the possible molecular insight into 5-FU resis...

journal_title：Current pharmaceutical design

authors： Tan Y,Qin S,Hou X,Qian X,Xia J,Li Y,Wang R,Chen C,Yang Q,Miele L,Wu Q,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:Transpeptidation reactions result in the formation of new peptide bonds and this can occur between two separate peptides or within the one peptide. These reactions are catalyzed by enzymes and when the N- and C-terminus of the one peptide are joined it results in the formation of cyclic proteins. Cyclization via head-...

journal_title：Current pharmaceutical design

authors： Conlan BF,Anderson MA

更新日期：2011-12-01 00:00:00

abstract：:Cathepsin K, a cysteine protease of the papain family, was identified by sequencing complementary DNA libraries derived from osteoclasts. Cathepsin K can cleave bone proteins such as Type I collagen, osteopontin, and osteonectin. The localization and maturation of cathepsin K in activated osteoclasts have been charact...

journal_title：Current pharmaceutical design

authors： Yamashita DS,Dodds RA

更新日期：2000-01-01 00:00:00

abstract：:Schizophrenia is a severe and frequent neuropsychiatric disorder. Despite antipsychotic medications, up to 30% of patients with schizophrenia still report disabling treatment-resistant symptoms. Transcranial direct current stimulation (tDCS) has been proposed as a novel method to alleviate such symptoms. Here, we revi...

journal_title：Current pharmaceutical design

authors： Mondino M,Brunelin J,Palm U,Brunoni AR,Poulet E,Fecteau S

更新日期：2015-01-01 00:00:00

abstract：:Drug designing targeting protein-protein interactions is challenging. Because structural elucidation and computational analysis have revealed the importance of hot spot residues in stabilizing these interactions, there have been on-going efforts to develop drugs which bind the hot spots and out-compete the native prot...

journal_title：Current pharmaceutical design

authors： Ma B,Nussinov R

更新日期：2014-01-01 00:00:00

abstract：:The endocannabinoid system (ECS) is now recognised as an important modulator of various central nervous system processes. More recently, an increasing body of evidence has accumulated to suggest antioxidant, anti-inflammatory and neuroprotective roles of ECS. In this review we discuss the role and therapeutic potentia...

journal_title：Current pharmaceutical design

authors： Velayudhan L,Van Diepen E,Marudkar M,Hands O,Suribhatla S,Prettyman R,Murray J,Baillon S,Bhattacharyya S

更新日期：2014-01-01 00:00:00

abstract：:Since antibiotics use is currently limited due to undesired side effects and the increasing antibiotic resistance of various bacteria strains, there is a pressing need to develop new strategies and methods preventing epidemic outbreaks. The virulent potency of bacteria relies on a number of different extracellularly s...

journal_title：Current pharmaceutical design

authors： Burchacka E,Sieńczyk M

更新日期：2018-01-01 00:00:00

abstract：:A correct representation of intermolecular interaction energies is necessary for reliable drug-receptor docking studies. While ab initio quantum chemistry with extended basis sets is the most accurate tool for that purpose, its use is precluded for very large molecular complexes. This constitutes the incentive for the...

journal_title：Current pharmaceutical design

authors： Gresh N

更新日期：2006-01-01 00:00:00