NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease.

abstract：:The mechanisms underlying neurodegeneration in amyotrophic lateral sclerosis (ALS) are multifactorial and include genetic and environmental factors. Nowadays, it is well accepted that neuronal loss is driven by non-cell autonomous toxicity. Non-neuronal cells, such as astrocytes, have been described to significantly c...

journal_title：Current pharmaceutical design

authors： Johann S

更新日期：2017-01-01 00:00:00

abstract：:DNA methyltransferase (DNMT) and histone deacetylase are key enzymes mediating the epigenetic regulation of gene expression. DNA hypermethylation and/or histone deacetylation in promoter regions is often associated with downregulation or silencing of transcription. Epigenetic silencing of tumor suppressor genes plays ...

journal_title：Current pharmaceutical design

authors： Xu S,Ren J,Chen HB,Wang Y,Liu Q,Zhang R,Jiang SW,Li J

更新日期：2014-01-01 00:00:00

abstract：:In order to productively infect a host, viruses must enter the cell and force host cell replication mechanisms to produce new infectious virus particles. The success of this process unfortunately results in disease progression and, in the case of infection with many viral species, may cause mortality. The discoveries ...

journal_title：Current pharmaceutical design

authors： Skoreński M,Sieńczyk M

更新日期：2013-01-01 00:00:00

abstract：:Cumulative recent evidence from clinical trials, observational studies and case reports has shown that subcutaneous administration of immunoglobulin (SCIg) exerts similar immunomodulatory capacity than intravenous immunoglobulin (IVIg) in autoimmune neurological diseases. Besides the beneficial clinical effects, the p...

journal_title：Current pharmaceutical design

authors： Sanchez-Ramon S,Corbi AL,Fidalgo AG,Dominguez-Soto A

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are considered a major health problem worldwide, being the main cause of mortality in developing and developed countries. Endothelial dysfunction, characterized by a decline in nitric oxide production and/or bioavailability, increased oxidative stress, decreased prostacyclin levels, and a...

journal_title：Current pharmaceutical design

authors： Blanco-Rivero J,Xavier FE

更新日期：2020-01-01 00:00:00

abstract：:There is a plausible role for cytokines, brain-derived neurotrophic factor (BDNF), and their interaction in major depressive disorder's (MDD) etiology. This review includes (i) briefly defining cytokines, (ii) a discussion of theories for why they may affect brain function, (iii) cross-sectional associations between c...

journal_title：Current pharmaceutical design

authors： Lotrich F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00

abstract：:Schizophrenia is a complex pathology characterized by the occurrence of a variety of symptoms classified as positive, negative and cognitive. Although the exact etiopathogenesis of this disorder has not been unraveled yet, many theories have been endorsed during the last years. Among these, the neurochemical theories ...

journal_title：Current pharmaceutical design

authors： Mhillaj E,Morgese MG,Trabace L

更新日期：2015-01-01 00:00:00

abstract：:The OB-receptor or leptin receptor (LR) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream. Under normal circumstances, circulating leptin levels are proportionate to the fat body mass. Sensing of elevated leptin levels ...

journal_title：Current pharmaceutical design

authors： Tutone M,Lauria A,Almerico AM

更新日期：2014-01-01 00:00:00

abstract：:Oncology remains an increasingly important focus of therapeutic development yet there remain many scientific and operational bottlenecks to deliver optimum treatments efficiently. Radiopharmaceuticals constitute a group of methodologies able to support the many stages of drug development. Methods such as [(18)F]-FDG-P...

journal_title：Current pharmaceutical design

authors： Murphy PS,Bergström M

更新日期：2009-01-01 00:00:00

abstract：:Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having s...

journal_title：Current pharmaceutical design

authors： Sismanopoulos N,Delivanis DA,Alysandratos KD,Angelidou A,Therianou A,Kalogeromitros D,Theoharides TC

更新日期：2012-01-01 00:00:00

abstract：:Drug-induced photosensitivity of the skin is drawing increasing attention. In past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem by clinicians, regulatory authorities and pharmaceutical industry. The photosensitivity is of two types i.e., ...

journal_title：Current pharmaceutical design

authors： Zaheer MR,Gupta A,Iqbal J,Zia Q,Ahmad A,Roohi,Owais M,Hashlamon A,Mohd Setapar SH,Ashraf GM,Aliev G

更新日期：2016-01-01 00:00:00

abstract：:Plasma concentrations of phytosterols and non-cholesterol sterol precursors of cholesterol synthesis have been used as markers of intestinal cholesterol absorption and synthesis in inherited and secondary dyslipidemias and in population-based investigations to evaluate the risk for cardiovascular disease, respectively...

journal_title：Current pharmaceutical design

authors： Quintão ECR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The last few decades have witnessed enormous advancements in the field of Pharmaceutical drug, design and delivery. One of the recent developments is the advent of 3DP technology. It has earlier been successfully employed in fields like aerospace, architecture, tissue engineering, biomedical research, medica...

journal_title：Current pharmaceutical design

authors： Mirza MA,Iqbal Z

更新日期：2018-01-01 00:00:00

abstract：:The survival of patients with pulmonary arterial hypertension is closely related with right ventricular function. During the progression of right ventricular remodeling, energetic metabolism shifts from oxidative mitochondrial metabolism to glycolysis. In normal physiological conditions, cardiomyocytes use major sourc...

journal_title：Current pharmaceutical design

authors： Zhang R,Jing ZC

更新日期：2016-01-01 00:00:00

abstract：:Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs)...

journal_title：Current pharmaceutical design

authors： Tu C,He J,Chen R,Li Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) has high mortality partly due to acquiring drug resistance during chemotherapy treatment. Therefore, it is necessary to explore the underlying mechanism of drug resistance. METHODS:We used 2-DE and MALDI-TOF-MS analysis to explore the possible molecular insight into 5-FU resis...

journal_title：Current pharmaceutical design

authors： Tan Y,Qin S,Hou X,Qian X,Xia J,Li Y,Wang R,Chen C,Yang Q,Miele L,Wu Q,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:Prostaglandin (PG) D(2), the major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is thought to contribute to the pathogenesis of allergic diseases due to its various inflammatory effects. However, the lack of PGD(2) (DP) receptor antagonists has limited the study of its essential role...

journal_title：Current pharmaceutical design

authors： Mitsumori S

更新日期：2004-01-01 00:00:00

abstract：:Natural products, or their synthetic derivatives are a treasure trove to find potential candidates for novel drugs for human treatment. The selection of diamonds from the huge pile of worthless stone is a critical--and difficult--stage in the discovery pipeline. Of all the factors to be considered, perhaps the most im...

journal_title：Current pharmaceutical design

authors： Wrzesinski K,Fey SJ

更新日期：2015-01-01 00:00:00

abstract：:Inflammation is a complex pathological condition associated with exaggerated human immune system involving various activated immune cells and bio-molecules. Treatment of inflammatory diseases particularly chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease etc. has been a big challen...

journal_title：Current pharmaceutical design

authors： Kulkarni RG,Achaiah G,Sastry GN

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism is the most common causes of secondary hypertension. Patients suffering from this clinical syndrome have an increased cardiovascular risk and target organ damage. Mineralocorticoid receptor antagonists are the optimal pharmaceutical option for the management of such patients. OBJECTIVE...

journal_title：Current pharmaceutical design

authors： Stavropoulos K,Papadopoulos C,Koutsampasopoulos K,Lales G,Mitas C,Doumas M

更新日期：2018-01-01 00:00:00

abstract：:Today, in spite of being older than a century (born in 1911), the Pictet-Spengler two component reaction (PS-2CR) is still one of the most popular reactions, not only for the synthesis of tetrahydroisoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), or more complex structures containing these two privileged moieti...

journal_title：Current pharmaceutical design

authors： Ingallina C,D'Acquarica I,Delle Monache G,Ghirga F,Quaglio D,Ghirga P,Berardozzi S,Markovic V,Botta B

更新日期：2016-01-01 00:00:00

abstract：:Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily t...

journal_title：Current pharmaceutical design

authors： Kaur H,Kumar V,Kumar K,Rathor S,Kumari P,Singh J

更新日期：2016-01-01 00:00:00

abstract：:Urological cancer refers to cancer in organs of the urinary system and the male reproductive system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously threatening patients' survival. Although there are many advances in the treatment of urological cancer, approved targeted therapies ofte...

journal_title：Current pharmaceutical design

authors： Liu Q,Gu J,Zhang E,He L,Yuan ZX

更新日期：2020-01-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin family and play pivotal roles in the innate immunity of the lung. Pulmonary collectins directly bind with broad specificities to a variety o...

journal_title：Current pharmaceutical design

authors： Takahashi H,Sano H,Chiba H,Kuroki Y

更新日期：2006-01-01 00:00:00

abstract：:Diabetes is one of the most common endocrine non-communicable metabolic disorders which is mainly caused either due to insufficient insulin or inefficient insulin or both together and is characterized by hyperglycemia. Diabetes emerged as a serious health issue in the industrialized and developing country especially i...

journal_title：Current pharmaceutical design

authors： Prabhakar PK,Sivakumar PM

更新日期：2019-01-01 00:00:00

abstract：:Recent advances in DNA sequencing has made it possible to accurately decipher the entire genetic complement of a probiotic bacterium. Increases in sequencing capabilities have been enhanced through improved computer software that can annotate, or identify, the majority of genes encoded by the sequence. The availabilit...

journal_title：Current pharmaceutical design

authors： Callanan M

更新日期：2005-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high mortality rate. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in normal intestinal tissue function, but has also been implicated in the development of CRC. MicroRNAs (miRNAs) have al...

journal_title：Current pharmaceutical design

authors： Moradi-Marjaneh R,Khazaei M,Ferns GA,Aghaee-Bakhtiari SH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Antiepileptic treatment strategy plays an important role in the management of intracranial vascular malformations. The intracranial vascular malformations can be divided into cavernous hemangiomas, arteriovenous malformations, developmental venous anomalies and capillary telangiectasias. Seizures and hemorrh...

journal_title：Current pharmaceutical design

authors： Giakoumettis D,Margetis K,Stranjalis G,Haliasos N,Papaioannou TG,Themistocleous MS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Absorption windows in particular segments of the small intestine can contribute to the development of orally administered drug formulations and can limit the bioavailability of released compounds. OBJECTIVE:The aim of this study was to evaluate use of wireless capsule enteroscopy regarding the disintegratio...

journal_title：Current pharmaceutical design

authors： Kvetina J,Tacheci I,Nobilis M,Kopacova M,Kunes M,Bures J

更新日期：2017-01-01 00:00:00