Further assessment to determine the additive effect of botulinum toxin type A on an upper extremity exercise program to enhance function among individuals with chronic stroke but extensor capability.

Abstract:

OBJECTIVE:To determine whether dose-specified botulinum toxin type A (BTX-A) and a standardized exercise protocol produce better upper extremity function than placebo and the same exercise program. DESIGN:Double-blind randomized trial. SETTING:A rehabilitation research center. PARTICIPANTS:A convenience sample of patients (N=25, age range, 23-76 y) who sustained a stroke 3 to 24 months previously but could initiate wrist extension. INTERVENTIONS:Participants were randomly selected to receive either BTX-A (maximum 300 U) or saline, followed by 12 to 16 exercise sessions. MAIN OUTCOME MEASURES:The primary outcome was the Wolf Motor Function Test (WMFT). Secondary outcome measures included the Modified Ashworth Scale (MAS), active range of motion, and the Stroke Impact Scale (SIS; quality of life). RESULTS:There were no group-by-time interactions for changes in the WMFT and no treatment difference (P=.86), although the BTX-A group could complete more tasks governing proximal joint motions. MAS scores improved for the BTX-A group and worsened for the control group after injection (P=.02), as did the SIS emotion domain (P=.035). CONCLUSIONS:Among chronic stroke survivors, BTX-A did not impact function, movement, or tone more than a standardized exercise program.

journal_name

Arch Phys Med Rehabil

authors

Wolf SL,Milton SB,Reiss A,Easley KA,Shenvi NV,Clark PC

doi

10.1016/j.apmr.2011.10.026

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

578-87

issue

4

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(11)00974-9

journal_volume

93

pub_type

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