Chemotherapy in pregnancy.

Abstract:

:One in 1000 pregnancies is complicated with cancer with the most common tumors being breast cancer, cervical cancer, thyroid, leukemia, lymphoma, and ovarian cancer. It is often assumed that cancer during pregnancy necessitates sacrificing the well-being of the fetus but in most cases appropriate treatment can be offered to the mother without placing the fetus at serious risk. The care of a pregnant woman with cancer involves evaluation of competing maternal and fetal risks and benefits. Although it is rare to administer chemotherapy during pregnancy, the risks depend on the drugs used and the gestational age of the fetus. During the period of organogenesis (4 to 13 wk), administration of cytotoxic drugs carries an increased risk of fetal malformations and fetal loss. Chemotherapy in the second or third trimester is associated with intrauterine growth retardation, prematurity, and low birth weight and bone marrow toxicity in many exposed infants.

journal_name

Clin Obstet Gynecol

authors

Brewer M,Kueck A,Runowicz CD

doi

10.1097/GRF.0b013e318236e9f9

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

602-18

issue

4

eissn

0009-9201

issn

1532-5520

pii

00003081-201112000-00011

journal_volume

54

pub_type

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