Comparison of first and second trimester aneuploidy risk assessment.

Abstract:

:Counseling regarding the options for aneuploidy risk assessment is complicated and requires thorough counseling with the patient. Second trimester serum risk assessment has been the gold standard because of widespread availability, low cost, and vast experience with counseling and performance. First trimester risk assessment is becoming more widely available and provides increased sensitivity for Down syndrome detection with a detection rate of approximately 87% (95% confidence interval: 84.0% to 89.4%), at a fixed false-positive rate of 5%. With the advent of first trimester techniques, controversy has arisen as there are advocates for the different recently available approaches. In this chapter, we outline the various options in a manner that will provide practical information for physicians offering such testing. Clearly, implementation of first trimester risk assessment requires special training and meticulous quality control standards for nuchal translucency and laboratory measurements, access to chorionic villus sampling, and also appropriate counseling regarding risk assessment options.

journal_name

Clin Obstet Gynecol

authors

Reddy UM,Wapner RJ

doi

10.1097/GRF.0b013e31804c9b99

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

442-53

issue

2

eissn

0009-9201

issn

1532-5520

pii

00003081-200706000-00013

journal_volume

50

pub_type

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