Clinical relevance of fetal gonadal structure and function.

Abstract:

:The foregoing discussion is consistent with the following conclusions: First structural differentiation of the gonads, consonant with chromosomal sex of human fetuses, requires complex interactions of primordial germ cells with coelomic and mesonephric epithelial cells and mesenchymal cells in the genital ridge. The mediators of these interactions remain to be defined. Second, the male fetal gonads secrete substances that direct differentiation of gonaducts and external genitalia along lines consonant with the sex chromosomal constitution. Third, when fetal gonads fail to secrete these substances or target tissues fail to respond, gonaducts or genitalia or both are either phenotypically female or ambiguous, regardless of fetal sex chromosomal constitution. Fourth, although the role of pituitary hormones in gonadal differentiation remains uncertain, the fetal pituitary appears to be required for maintenance of structural and functional integrity of differentiated fetal gonads.

journal_name

Clin Obstet Gynecol

authors

diZerega GS,Ross GT

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

849-61

issue

3

eissn

0009-9201

issn

1532-5520

journal_volume

23

pub_type

杂志文章
  • Sonographic diagnosis of fetal growth disorders.

    abstract::In summary, accurate identification of fetal growth disorders remains a difficult clinical challenge. Many diagnostic parameters have been devised to diagnose these conditions, however, no single test alone allows a confident antenatal diagnosis of IUGR or macrosomia to be established. Until new criteria or new method...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198803000-00007

    authors: Mintz MC,Landon MB

    更新日期:1988-03-01 00:00:00

  • Low-Molecular-Weight Heparin for the Prevention of Placenta-mediated Pregnancy Complications.

    abstract::During the past decade, prophylactic doses of low-molecular-weight heparin (LMWH) have been suggested to decrease the risk of placental-mediated complications. Herein, we review the prospective randomized trials that addressed the usefulness of LMWH in preventing placental-mediated complications in high-risk women. In...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0000000000000252

    authors: Haddad B,Lecarpentier E,Touboul C,Sibai BM

    更新日期:2017-03-01 00:00:00

  • Sexual pain.

    abstract::Sexual pain is an underrecognized and poorly treated constellation of disorders that significantly impact affected women and their partners. Recognized as a form of chronic pain, sexual pain disorders are heterogeneous and include dyspareunia (superficial and deep), vaginismus, vulvodynia, vestibulitis, and noncoital ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3181bf4a7e

    authors: Boardman LA,Stockdale CK

    更新日期:2009-12-01 00:00:00

  • Pathology of the adnexal mass.

    abstract::An "adnexal mass" is a common specimen encountered in the daily pathology practice. Although most are benign, the incidence of malignancy increases with age, and approximately 30% are malignant in postmenopausal females. Herein we describe the salient macroscopic and microscopic features of the most prevalent adnexal ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0000000000000082

    authors: Bennett JA,Oliva E

    更新日期:2015-03-01 00:00:00

  • Ethics in reproductive genetics.

    abstract::Ethics in reproductive genetics comprise descriptive ethics and normative ethics. Ethical problems before prenatal diagnosis involve genetic counseling and informed consent for the choice patients must make. Prenatal diagnosis using amniocentesis is controversial. An international survey of geneticists showed that ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-199212000-00009

    authors: Fletcher JC,Evans MI

    更新日期:1992-12-01 00:00:00

  • Human papillomavirus and cervical lesions.

    abstract::Human papillomavirus (HPV) infection has been implicated in the intraepithelial cervical changes that cause most abnormal Papanicolaou smears. To date, 14 types of HPVs have been identified. All are small, nondeveloped, icosahedral DNA viruses that share a common internal antigen. In cases of cervical HPV infection...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-198312000-00019

    authors: Roy M,Morin C,Casas-Cordero M,Meisels A

    更新日期:1983-12-01 00:00:00

  • Oral agents for the management of gestational diabetes.

    abstract::In gestational diabetes (GDM), achieving euglycemia through treatment decreases the risk of adverse outcomes associated with hyperglycemia. Treatment starts with diet and nutritional counseling; however, up to 50% of women will require pharmacologic therapy to meet glucose goals. Although insulin remains the only Fede...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3182a8e0a5

    authors: Berggren EK,Boggess KA

    更新日期:2013-12-01 00:00:00

  • Application of computer technology to reproductive endocrinology.

    abstract::Data manipulation and information management activities are as central to physicians as writing is to the literary profession. It is not surprising that the computer, as an information tool, has become important and accepted in many aspects of our professional lives. Computer applications can significantly help in dai...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-198909000-00024

    authors: Jelovsek FR

    更新日期:1989-09-01 00:00:00

  • The postpartum management of women with gestational diabetes using a continuum model for health care.

    abstract::Women with gestational diabetes mellitus require a continuum of care before, during, and after pregnancy for optimal management of hyperglycemia. Postpartum education and lifestyle modification should begin during pregnancy, and should continue during the postpartum period. Women should receive education on the long-t...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3182a8e0bb

    authors: Castorino K,Jovanovič L

    更新日期:2013-12-01 00:00:00

  • Viral infections in pregnancy.

    abstract::The responsibility of the physician for viral infections in pregnancy has changed dramatically in the last 15 years. Genital herpes infections have become much more frequent, and the recognition of these infections in women near term is particularly important. Cytomegaloviruses have been found to be the most commom ca...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-197806000-00018

    authors: Sever JL

    更新日期:1978-06-01 00:00:00

  • Failed Intrauterine Pregnancy: What Is a Failed Pregnancy, What Is Not?

    abstract::Pregnancy failure is defined as a lack of sonographic evidence of current or expected viability. Technologic advances in ultrasound imaging continue to redefine diagnostic criteria of pregnancy failure or success. When evaluating a pregnancy, the first step is an assessment of maternal risk factors for failure. Imagin...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0000000000000301

    authors: Canavan TP

    更新日期:2017-09-01 00:00:00

  • Fetal adrenal medulla.

    abstract::The development of the fetal adrenal medulla can be considered an integral part of the complex process of maturation and preparation of the fetus for extrauterine life. Our understanding of the fetal sympathoadrenal function is facilitated by the relative separation that exists between the maternal and fetal catechola...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Artal R

    更新日期:1980-09-01 00:00:00

  • Reversible antepartum fetal distress.

    abstract::Information generated from the various tests of fetal well-being must be interpreted correctly to avoid unnecessary intervention for assumed fetal distress. This applies to both the intrapartum and antenatal period. The presence of normal data (e.g., reassuring fetal heart rate tracing) allows the woman to continue co...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198712000-00023

    authors: Nageotte MP

    更新日期:1987-12-01 00:00:00

  • Ultrasound evaluation of the postdate pregnancy.

    abstract::In summary, ultrasound plays an important role in the evaluation of the postterm pregnancy, and its use should be considered in the following situations: 1) estimation of fetal weight in the potentially macrosomic infant before vaginal delivery is attempted; 2) frequent evaluation for oligohydramnios using the amnioti...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198906000-00008

    authors: Rodriguez MH

    更新日期:1989-06-01 00:00:00

  • Antibiotics in pregnancy.

    abstract::Because it is known that antibiotics given to the mother may reach and affect the fetus, when prescribing antibiotics during pregnancy, one must take into consideration both maternal and fetal well-being. Therapy should be directed toward the maternal disease but also be safe for the fetus. The volume of distribution ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-199312000-00012

    authors: Hedstrom S,Martens MG

    更新日期:1993-12-01 00:00:00

  • Oral misoprostol administration for labor induction.

    abstract::Using oral agents for induction of labor would reduce the need for repeated vaginal examinations; this is more acceptable to women and could reduce infection rates. A systematic review was conducted of 41 randomized trials comparing oral misoprostol to other induction agents. Oral misoprostol is effective at achieving...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-200609000-00023

    authors: Weeks A,Alfirevic Z

    更新日期:2006-09-01 00:00:00

  • Dynamic ultrasound-based fetal assessment: the fetal biophysical profile score.

    abstract::The advent of ultrasound fetal imaging and the evolution of dynamic imaging (real-time) methods have opened great new vistas in which fetal responses can be monitored with remarkable precision and clarity. Contained within this new wealth of information may lie the key to direct determination of the fetus at risk for ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199503000-00006

    authors: Manning FA

    更新日期:1995-03-01 00:00:00

  • Controversies in Screening Mammography.

    abstract::The utility and effectiveness of screening mammography in diagnosing breast cancer at earlier stages and reducing disease-specific mortality remain controversial especially as to when to start and stop routine mammographic screening, and whether mammograms should be performed annually or biennially in average-risk wom...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0000000000000205

    authors: Swain M,Jeudy M,Pearlman MD

    更新日期:2016-06-01 00:00:00

  • Surgical diseases of the breast during pregnancy.

    abstract::Physicians caring for women with diseases of the breast are well aware of the time lost before many patients consult their physicians. Nowhere is this more apparent than when a breast mass is associated with gestation or lactation. Enlargement of the breast tends to obscure parenchymal masses. Those that are found are...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00003081-198312000-00010

    authors: Canter JW,Oliver GC,Zaloudek CJ

    更新日期:1983-12-01 00:00:00

  • Prenatal programming of insulin secretion in intrauterine growth restriction.

    abstract::Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal models of IUGR. Several underlying mechanisms have been implicated, including decreased expression of molecular regulators of β-cell mass and function, in some cases shown to be due to epigenetic changes initiated by an adverse fe...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31829e5b29

    authors: Gatford KL,Simmons RA

    更新日期:2013-09-01 00:00:00

  • Bacterial vaginitis.

    abstract::Bacterial vaginitis is responsible for approximately 10 million office visits per year. This condition may disrupt marriages and cause psychologic stress that may be reflected in the individual's work and social life. Bacterial vaginitis also has been thought to lead to postpartum endometritis, pelvic cellulitis, pelv...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Faro S

    更新日期:1991-09-01 00:00:00

  • Impact of antenatal and postpartum maternal mental illness: how are the children?

    abstract::Prospective studies that begin during pregnancy and follow the mothers and children into adolescence have shown that maternal mental illness during the antenatal and postpartum period can have long-lasting negative consequences on the developing child. The findings from these prospective studies and a discussion of th...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e3181b52930

    authors: Brand SR,Brennan PA

    更新日期:2009-09-01 00:00:00

  • Human papillomavirus and cervical disease in adolescents.

    abstract::The addition of the human papillomavirus vaccination and the 2006 national guidelines for the management of abnormal cervical cytology have led to significant changes in the management of cervical disease among adolescents. This article reviews recommendations for prevention, screening, diagnosis, and management of ce...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e318172d0dc

    authors: Guido R

    更新日期:2008-06-01 00:00:00

  • Epidemiology and risk factors.

    abstract::HBC is common, accounting for approximately 9% of the total breast cancer burden. Given 142,000 cases of breast cancer expected to occur in 1989, this would represent 12,780 cases of HBC patients. Soberingly, each patient represents a family with a variable number of inordinately high risk patients. HBC's natural hist...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-198912000-00018

    authors: Lynch HT,Watson P,Lynch JF

    更新日期:1989-12-01 00:00:00

  • Management of hypothyroidism during pregnancy.

    abstract::Hypothyroidism during pregnancy occurs in 1/1600-2000 deliveries, according to the most recent publications. The most common causes are chronic autoimmune thyroid disease, radiodine-131 treatment, or surgical removal. The diagnosis is difficult to make on clinical grounds alone, even in advanced cases, and a high inde...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00003081-199703000-00008

    authors: Montoro MN

    更新日期:1997-03-01 00:00:00

  • Intrahepatic Cholestasis of Pregnancy.

    abstract::Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and management is difficult due to the paucity of data regarding its diagnosis, treatment, and related adverse outcomes. In this article, we review th...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0000000000000495

    authors: Smith DD,Rood KM

    更新日期:2020-03-01 00:00:00

  • Magnetic resonance-guided focused ultrasound surgery.

    abstract::Uterine leiomyomas pose a significant health issue to reproductive-age women. Many women desire uterine conservation, and previously safe and efficacious therapies have been limited. Magnetic resonance-guided focused ultrasound surgery is a new noninvasive therapy that has been proven to be both safe and efficacious i...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e318161e91f

    authors: Hudson SB,Stewart EA

    更新日期:2008-03-01 00:00:00

  • Preterm PROM: prediction, prevention, principles.

    abstract::Preterm premature rupture of the membranes remains difficult to predict accurately. The majority of those suffering preterm premature rupture of the membrane lack risk factors that might lead to preventative treatments. Its management is centered on an evaluation of the risks and benefits of attempted pregnancy prolon...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/GRF.0b013e318217d4d3

    authors: Waters TP,Mercer B

    更新日期:2011-06-01 00:00:00

  • Nutrition and pregnancy.

    abstract::The importance of nutrition during pregnancy with regard to pregnancy outcome has long been acknowledged. This importance has only been further emphasized by the recent changes in food quality and availability, lifestyle changes, and a new understanding of fetal programming on adult outcomes. The impact of the recent ...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0b013e31816fda53

    authors: Mehta SH

    更新日期:2008-06-01 00:00:00

  • Cardiac arrest during pregnancy.

    abstract::Cardiac arrest is a rare event during pregnancy. The pregnant population represents a unique subset of cardiac arrest victims. Not only are there unique causes of circulatory collapse during the pregnant state, but the physiological modifications to the maternal physiology during pregnancy require specific modificatio...

    journal_title:Clinical obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GRF.0000000000000075

    authors: Montufar-Rueda C,Gei A

    更新日期:2014-12-01 00:00:00