Abstract:
PURPOSE:Obesity in adolescence increases the risk for early adult cardiovascular disease. We recently showed that 6 months of diet, exercise, and metformin resulted in reductions in adiposity and that diet/exercise alone reduced proinflammatory factors and intrahepatic fat in pubertal children with uncomplicated obesity. The purpose of the present study was to determine whether changes in cardiorespiratory fitness (CRF) after 6 months of structured diet and exercise (DE) or DE plus metformin are related to the previously observed changes in adiposity, markers of inflammation, and intrahepatic fat. METHODS:Sixteen obese pubertal adolescents between the ages of 10 and 17 were randomized into a structured lifestyle program consisting of DE or DE plus metformin. Subjects performed aerobic and resistance exercise 3 d·wk⁻¹, 30 min per session. Cycle ergometer maximal oxygen consumption (V˙O2max), body composition, blood markers (glucose, insulin, homeostatic model assessment-insulin resistance, interleukin-6, hsCRP), and intrahepatic fat were measured at baseline and 6 months. RESULTS:In the cohort, as whole-body weight decreased by 4.0% (P = 0.009), body mass index decreased by 4.9% (P = 0.003), percent body fat decreased by 8.8% (P < 0.001), and V˙O2max improved in 10 of 16 subjects. The addition of metformin provided no further effect on body composition, CRF, or inflammatory factors. More favorable changes in adiposity, adiponectin, and a trend toward blood glucose and interleukin-6 concentrations (P = 0.07) were observed in subjects who increased V˙O2max at 6 months (n = 10) compared with no change in these variables in those who did not improve V˙O2max. CONCLUSIONS:Metformin did not provide benefits above lifestyle modification for improving CRF in obese adolescents. Improvements in V˙O2max seem to be associated with more favorable metabolic outcomes.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Rynders C,Weltman A,Delgiorno C,Balagopal P,Damaso L,Killen K,Mauras Ndoi
10.1249/MSS.0b013e31823cef5esubject
Has Abstractpub_date
2012-05-01 00:00:00pages
786-92issue
5eissn
0195-9131issn
1530-0315journal_volume
44pub_type
杂志文章,随机对照试验abstract:INTRODUCTION:Muscle force production is usually impaired in people with spinal cord injury (SCI). The use of high-intensity neuromuscular electrical stimulation (NMES) strength training can help promote metabolically active lean muscle mass and, thus, increase muscle mass and improve physical health and quality of life...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001637
更新日期:2018-09-01 00:00:00
abstract::Natural killer (NK) cells are highly influenced by physical exercise. The possible important mechanisms behind exercise-induced changes in NK cell function are cytokines, hyperthermia, and stress hormones, including catecholamines, growth hormone, cortisol, and beta-endorphins. Infusion studies mimicking stress hormon...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/00005768-199402000-00003
更新日期:1994-02-01 00:00:00
abstract::The cell-to-cell lactate shuttle was introduced in 1984 and has been repeatedly supported by studies using a variety of experimental approaches. Because of its large mass and metabolic capacity, skeletal muscle is probably the major component of the lactate shuttle in terms of both production and consumption. Muscles ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0b013e31815fa580
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:The main purpose of the present study was to measure the total oxygen consumed, accumulation of blood metabolites, and performance during alternating intensity exercise before and after a period of creatine (Cr) loading in well-trained humans. METHODS:Fourteen males were randomly assigned to two groups of seve...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200002000-00018
更新日期:2000-02-01 00:00:00
abstract:PURPOSE:The present longitudinal study assessed cardiorespiratory capacity and running economy of Olympic athletes over several decades to measure changes in fitness in an elite group during aging. METHODS:Twenty-six male runners training for the 1968 Olympics were recruited. HR, V˙O2max, ventilation, and running econ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001407
更新日期:2018-01-01 00:00:00
abstract::Six adult females with normal menstrual cycles (28-31 d in length) volunteered to exercise on a bicycle ergometer on five different days of their menstrual cycles (days 2, 8, 14, 20, and 26; day 1 = onset of menstruation). Each day the subjects exercised at a maximum work load (184.4 W) and at four submaximal exercise...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Chronically increased contractile activity by low-frequency stimulation induces a transformation of fast- into slow-twitch muscle fibers in the rabbit. This transformation is progressive with the duration of the stimulation and affects various functional systems of the muscle fiber in an orderly sequence. Early change...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1984-12-01 00:00:00
abstract::We investigated the relationship of aerobic fitness to the response of volume-regulating hormones to acute simulated microgravity. Six untrained (UT) and six endurance-trained (ET) healthy young males were studied in the head-down tilt (HDT) position of -6 degrees for 4 h. Peak oxygen uptake (VO2peak) and plasma volum...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::Facial cooling (FC) elicits a marked bradycardia at rest that appears to be reduced during exercise. This study was done to delineate the effects of exercise mediated central command from those of muscle afferent feedback and sympathetic stimulation on the attenuation of the bradycardic effect of FC during the onset o...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199703000-00006
更新日期:1997-03-01 00:00:00
abstract::The present investigation was conducted to determine whether critical power (CP) assesses the ability to perform continuous aerobic exercise and to determine whether training-induced changes in aerobic endurance are reflected by changes in the slope, but not the y-intercept of the CP function. Twelve healthy, active, ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:PURPOSE:The prevalence of allergy and asthma symptoms and asthma medication use, which has been extensively studied in elite athletes, has received little attention in recreational roadrunners. METHODS:A validated questionnaire was used to determine the prevalence of allergy and asthma symptoms, the use of medication,...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000235357.31932.43
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:This study aimed to investigate atrophy in the deep abdominal muscles, spinal extensors, and the effect of high-load resistive exercise with and without whole-body vibration after 60 d of strict bed rest. METHODS:Twenty-four subjects underwent 60 d of head-down tilt bed rest and performed either resistive vibr...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001096
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Fit individuals with metabolic syndrome (MetS) have lower mortality risk compared with less fit counterparts, despite the presence of obesity as a component of the syndrome. To understand the importance of fitness in treating this condition, we examined the association of fitness and fatness with central hemody...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000916
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the relative association of physical activity, cardiorespiratory fitness (CRF), and adiposity with C-reactive protein (CRP) in prepubescent children. METHODS:Forty-five prepubescent children (age = 9.4 ± 1.6 yr; 26 boys) were assessed for adiposity (percent fat) via dua...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181e0355e
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:This study aimed to examine the link between stress (measured via salivary cortisol and testosterone), cognition (measured via pupillometry, with greater pupil constriction and reduced pupil constriction latency associated with increased attention and improved information processing), and motor skill capacity (...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002397
更新日期:2020-11-01 00:00:00
abstract::Fatigue can be defined as the failure to maintain an expected power output. This is often an antecedent to some sports-related injury. It is important for those involved in physical performance to be familiar with the variety of mechanisms which can lead to fatigue. All too often, a single factor is described as the c...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract::: The relevance of translational medicine (bringing basic science methods "to the bed of patients") is universally recognized. Too often, however, the tools to be applied translationally are thought to derive only from the "-omics" (genomics, proteomics, transcriptomics, metabolomics, etc.) world. The failures of this...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0000000000002056
更新日期:2019-11-01 00:00:00
abstract::Cardiovascular responses were obtained during cycling with graded levels of lower-body positive pressure (LBPP) applied to the exercising limbs. Seven men performed four incremental work rate (25 W.min-1) exercise (IWREx) tests to their limit of tolerance while exposed to 0, 15, 30, or 45 Torr LBPP. They also performe...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199406000-00008
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. METHODS:A total of 37 symptomatic patients at risk of PA...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318204cdac
更新日期:2011-06-01 00:00:00
abstract::The relationships between individual performance and lactate exchange and removal abilities were studies in 12 male rowers all subjected to three measurements on a rowing ergometer. An incremental exercise carried out to determine the maximal oxygen uptake (VO2max) and the corresponding maximal aerobic power (Pamax), ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199703000-00016
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare the biomechanical changes during natural heel-toe running with learned midfoot and Pose running. METHODS:Twenty heel-toe runners were instructed in midfoot running and a novel running style in which the acromium, greater trochanter, and lateral malleolus are aligned in stan...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.MSS.0000113684.61351.B0
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:The purpose of this paper was to determine whether differences in hemoglobin (Hb) and muscle aerobic capacity exist between African-American (AA) and Caucasian (CA) premenopausal women and to determine whether Hb and aerobic capacity of the muscle are associated with the racial differences in maximum oxygen upt...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200110000-00019
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:Compare three published methods of quantifying physical activity (total activity, peak strain, and bone-loading exposure (BLE) scores) and identify their associations with areal bone mineral density (aBMD), volumetric BMD (vBMD), and bone strength. METHODS:Postmenopausal women (N = 239; mean age: 53.8 yr) from...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,多中心研究
doi:10.1249/mss.0b013e318155a7fe
更新日期:2007-12-01 00:00:00
abstract::This study characterizes exercise-induced lipid peroxidation during graded aerobic exercise in seven healthy men and women (36.4 +/- 3 yr). Levels of ethane and pentane in expired breath during cardiopulmonary exercise stress testing were measured at rest, lactic acidosis threshold (LAT), maximal exercise (VO2max), an...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199708000-00008
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:Physical fitness and physical activity tracking data enhance our understanding as to when children settle into their long-term exercise and fitness patterns and, therefore. provide insight as to when programs focusing on preventing sedentary adults behaviors should be initiated. METHODS:In this paper, the trac...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200007000-00011
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:This study was designed to determine changes in metabolic and cardiovascular risk factors following normobaric hypoxic exercise training in healthy men. METHODS:Following a randomized baseline maximal exercise test in hypoxia and/or normoxia, 34 physically active subjects were randomly assigned to either a nor...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200006000-00004
更新日期:2000-06-01 00:00:00
abstract:UNLABELLED:Several investigators have demonstrated that chronic eccentric leg cycling is an effective method for improving lower body neuromuscular function (e.g., quadriceps muscle size, strength, and mobility) in a variety of patient and athletic populations. To date, there are no reports of using eccentric arm cycli...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0b013e318269c79c
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Stroke volume response to exercise depends on changes in cardiac filling, intrinsic myocardial contractility, and left ventricular afterload. The purpose of this study was to compare these responses during an upright cycle test performed until exhaustion in children and adults. METHODS:Stroke volume, cardiac o...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200203000-00012
更新日期:2002-03-01 00:00:00
abstract::During the past three to four decades, a significant amount of data was collected to reinforce the notion that mitochondrial function is irrevocably linked to mitochondrial structure. Indeed, data from numerous studies have revealed several salient points of mitochondrial biology that include the following: 1). mitoch...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200301000-00014
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Strain magnitude is known to be a primary determinant of the osteogenic response to loading. However, whether bone adaptation to muscle loading is determined primarily by load magnitude is unclear. The purpose of this study was to determine the contribution of load magnitude from muscle action on the site-speci...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199909000-00009
更新日期:1999-09-01 00:00:00