Abstract：
:The cell-to-cell lactate shuttle was introduced in 1984 and has been repeatedly supported by studies using a variety of experimental approaches. Because of its large mass and metabolic capacity, skeletal muscle is probably the major component of the lactate shuttle in terms of both production and consumption. Muscles exercising in a steady state are avid consumers of lactate, using most of the lactate as an oxidative fuel. Cardiac muscle is highly oxidative and readily uses lactate as a fuel. Lactate is a major gluconeogenic substrate for the liver; the use of lactate to form glucose increases when blood lactate concentration is elevated. Illustrative of the widespread shuttling of lactate, even the brain takes up lactate when the blood level is increased. Recently, an intracellular lactate shuttle has also been proposed. Although disagreements abound, current evidence suggests that lactate is the primary end-product of glycolysis at cellular sites remote from mitochondria. This lactate could subsequently diffuse to areas adjacent to mitochondria. Evidence is against lactate oxidation within the mitochondrial matrix, but a viable hypothesis is that lactate could be converted to pyruvate by a lactate oxidation complex with lactate dehydrogenase located on the outer surface of the inner mitochondrial membrane. In another controversial area, the role of lactic acid in acid-base balance has been hotly debated in recent times. Careful analysis reveals that lactate, not lactic acid, is the substrate/product of metabolic reactions. One view is that lactate formation alleviates acidosis, whereas another is that lactate is a causative factor in acidosis. Surprisingly, there is little direct mechanistic evidence regarding cause and effect in acid-base balance. However, there is insufficient evidence to discard the term "lactic acidosis."
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Gladden LBdoi
10.1249/MSS.0b013e31815fa580subject
Has Abstractpub_date
2008-03-01 00:00:00pages
477-85issue
3eissn
0195-9131issn
1530-0315journal_volume
40pub_type
杂志文章,评审abstract：PURPOSE:We tested the hypothesis that critical velocity (CV) during intermittent running with changes of direction is reliably and accurately identified from a simple shuttle field test. We also tested the hypothesis that CV during intermittent running with changes of direction running is not equivalent to continuous l...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001774
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:A 20-d 6 degrees head-down tilt bed rest project was conducted to evaluate the effect of dynamic leg press and plantar flexion resistance training on muscle size and function in human plantar flexors (PF) throughout the prolonged bed rest. METHODS:Twelve healthy men participated in this study and were divided ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1249/01.MSS.0000058367.66796.35
更新日期：2003-04-01 00:00:00
abstract：PURPOSE:The goal of this trial was to determine whether low-load blood flow-restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in pe...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000001984
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:The purpose of this study was to examine the ability of the SenseWear Pro2 Armband (SWA) to accurately assess energy expenditure in free-living overweight or obese children during a 2-wk period by comparison with energy expenditure measured using the doubly labeled water (DLW) method. A second aim was to examin...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181c84091
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:This study examined the effect of endurance exercise on dendritic arborization in the dentate gyrus subregion in rodents exposed to a predator scent stress (PSS). METHODS:Sprague-Dawley rats were randomly assigned to one of four treatment groups. In two of the groups, rats were unexposed to PSS but either...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001038
更新日期：2016-12-01 00:00:00
abstract：INTRODUCTION:Oral beta2-agonist administration improves muscle function in persons without asthma. We performed a double-blind, randomized, controlled crossover study to assess whether acute inhaled salbutamol administration improves muscle strength and fatigability in healthy moderately trained subjects. METHODS:Quad...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e31816b87aa
更新日期：2008-07-01 00:00:00
abstract：:Studies using wearable sensors to measure posture, physical activity (PA), and sedentary behavior typically use a single sensor worn on the ankle, thigh, wrist, or hip. Although the use of single sensors may be convenient, using multiple sensors is becoming more practical as sensors miniaturize. PURPOSE:We evaluated ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002306
更新日期：2020-08-01 00:00:00
abstract：:The relationship between VO2 and velocity of running (running economy) has been rather casually dealt with until very recently, and there still remains considerable disagreement as to the importance of this variable. Various factors which have been shown, or appear, to affect running economy include environment (tempe...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1985-06-01 00:00:00
abstract：UNLABELLED:Controversy surrounds whether running mechanics make good predictors of running economy (RE) with little known about the development of an economical running gait. PURPOSE:The aim of this study was to identify if mechanical or physiological variables changed during 10 wk of running in beginners and whether ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318255a727
更新日期：2012-09-01 00:00:00
abstract：:The ventilatory threshold (VT) has been suggested as a method for determining exercise training intensity in cardiac transplant patients (CTPs). Since the VT has not been validated against the more accepted marker of the anaerobic threshold, the lactate threshold (LT), in CTPs, the purpose of this investigation was to...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：PURPOSE:Cardiac troponin T (cTnT) is a highly specific marker of myocardial damage and used clinically in the diagnosis of acute myocardial infarction (AMI). Release of cTnT has been demonstrated in several small studies after endurance exercise. The purpose of this study was to explore, using a meta-analytic approach,...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,meta分析
doi：10.1249/mss.0b013e318153ff78
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation, and strain. We evaluated baseline and exerc...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001806
更新日期：2019-03-01 00:00:00
abstract：:The physiological mechanism of exercise-induced hyperfibrinolysis is not fully understood. It has been reported that exercise increases plasma arginine vasopressin (PAVP) and that PAVP infusion enhances blood fibrinolytic activity (FA). To characterize the fibrinolytic role of PAVP during exercise, PAVP and FA were ex...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:To determine the effect of large and sudden increases in training volume on performance characteristics and the feasibility of using overtraining syndrome symptoms to monitor performance changes, 15 elite judo athletes were examined through 10 wk of training. Athletes performed their regular regimens of resistance (3 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199012000-00014
更新日期：1990-12-01 00:00:00
abstract：:This report demonstrates the effect of voluntary exercise in attenuating increases in heart rate (HR) caused by chronic stress in an animal model of stress-induced hypertension, the borderline hypertensive rat (BHR). Exercise training also protected against the hypertensive effects of stress in 16-wk-old, but not 10-w...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：PURPOSE:A potential confounding factor in the interpretation of left ventricular (LV) structural and functional data in female subjects could be menstrual phase or contraceptive use upon assessment. To date no study has addressed this issue. METHODS:Seventeen eumenorrheic (EU; mean +/- SD age = 21 +/- 3 yr) and 14 com...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200002000-00008
更新日期：2000-02-01 00:00:00
abstract：INTRODUCTION:The isometric muscle force attained after active stretch is greater than that attained in a purely isometric contraction. This property is referred to as residual force enhancement (RFE). Because RFE is thought to be caused by a titin-based passive force, it should be preserved in reduced contractile force...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001563
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Compelling evidence suggests larger performance decrements during hypoxic versus normoxic repeated sprinting. Yet the underlying mechanical alterations have not been thoroughly investigated. Therefore, we examined the effects of different levels of normobaric hypoxia on running mechanical performance during rep...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000000937
更新日期：2016-08-01 00:00:00
abstract：:Twenty well-trained runners (VO2max 4.6+/-0.5 L x min[-1]) were age and ability matched and assigned to either a cross training (CT) or run only group (RT). All subjects maintained normal running distance and intensity for 6 wk and reported for three additional training sessions per week. These workouts were performed...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199802000-00019
更新日期：1998-02-01 00:00:00
abstract：:The assumption that lower extremity function is bilaterally symmetrical is prevalent throughout the biomechanics literature. The unilateral development of many overuse and acute injuries may suggest that this assumption is inaccurate. Analyses of bilateral function report conflicting results and may be partially attri...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Cardiovascular responses were obtained during cycling with graded levels of lower-body positive pressure (LBPP) applied to the exercising limbs. Seven men performed four incremental work rate (25 W.min-1) exercise (IWREx) tests to their limit of tolerance while exposed to 0, 15, 30, or 45 Torr LBPP. They also performe...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199406000-00008
更新日期：1994-06-01 00:00:00
abstract：PURPOSE:We examined the effect of electric fan use on cardiovascular and thermoregulatory responses of nine young (26 ± 3 yr) and nine aged (68 ± 4 yr) adults exposed to extreme heat and humidity. METHODS:While resting at a temperature of 42°C, relative humidity increased from 30% to 70% in 2% increments every 5 min. ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000001348
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:One approach to studying the effects of aging on physiological functional capacity (PFC) in humans is to analyze the peak physical performance of trained athletes with increasing age. The primary aim of the present study was to determine weightlifting and powerlifting performance with increasing age in both men...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000106283.34742.BE
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To characterize the hemodynamic and ventilatory responses to exercise in a group of patients with unexplained dyspnea, increased risk for pulmonary arterial hypertension (PAH), and an elevated mean pulmonary artery pressure (mPAP; >30 mm Hg) on exercise. METHODS:A total of 37 symptomatic patients at risk of PA...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318204cdac
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To evaluate the effects of a 12-wk period of aquatic training and subsequent detraining on health-related quality of life (HRQOL) and physical fitness in females with fibromyalgia. METHODS:Thirty-four females with fibromyalgia were randomly assigned into two groups: an exercise group, who exercised for 60 min ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/01.mss.0b0138059aec4
更新日期：2007-07-01 00:00:00
abstract：:The influence of body weight on the performance in cross-country skiing has been studied by: dimensional analysis of the ratio (R) between the factors of importance to power production (VO2max, acceleration of gravity) and the braking powers, e.g., friction and air resistance; measuring the energy cost of level skiing...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:For high-intensity muscular exercise, the time-to-exhaustion (t) increases as a predictable and hyperbolic function of decreasing power (P) or velocity (V ). This relationship is highly conserved across diverse species and different modes of exercise and is well described by two parameters: the "critical power" (CP or...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：10.1249/MSS.0b013e3181d9cf7f
更新日期：2010-10-01 00:00:00
abstract：:Laboratory studies using direct calorimetry, a technique which is no longer either rare or difficult, have shown no essential differences between men and women who gain weight easily and the always lean. Both groups gained weight similarly when overeating by 1,000 kcal X d-1. Thermogenic responses to eating and the en...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1986-02-01 00:00:00
abstract：INTRODUCTION:Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. METHODS:We aimed to prospectively examine individual and joint associations ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001448
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:Increasing step rate has been shown to elicit changes in joint kinematics and kinetics during running, and it has been suggested as a possible rehabilitation strategy for runners with patellofemoral pain. The purpose of this study was to determine how altering step rate affects internal muscle forces and patell...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3182a78c3a
更新日期：2014-03-01 00:00:00
