Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells.

Abstract:

:Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intra-cellular bacterium that survives in neutrophils by delaying apoptosis. The human promyelocytic leukemia cell line HL-60 has been the ultimate choice for culturing Anaplasma in vitro. In this study, we assessed the various events of drug-induced apoptosis in A. phagocytophilum-infected HL-60 cells. Anaplasma infection reduced the cell viability and increased the apoptosis in HL-60 cells and staurosporine or etoposide-induced apoptosis was further exacerbated with Anaplasma infection. Altogether our results suggest that A. phagocytophilum infection is proapoptotic in HL-60 cells unlike in neutrophils where it is antiapoptotic.

authors

Karki P,Ijdo JW

doi

10.1007/s11274-011-0745-z

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

2741-2746

issue

11

eissn

0959-3993

issn

1573-0972

journal_volume

27

pub_type

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