Expression differential of microsomal and cytosolic glutathione-S-transferases in Fasciola hepatica resistant at triclabendazole.

Abstract:

:In the present work, we evaluate in vitro the cytosolic and microsomal activity of glutathione-S-transferases in adults of Fasciola hepatica susceptible (Cullompton Strain) and resistant (Sligo Strain) to triclabendazole. The triclabendazole resistant (Sligo) fluke expressed significant major metabolic activity of glutathione-S-transferases compared to that measured in the cytosolic and microsomal fractions obtained from susceptible flukes (Cullompton Strain). The results associated with previous data where the Sligo Strain overexpress Flavin Monooxigenase confirm a multienzymatic response involving more than one metabolic pathway.

journal_name

Mol Biochem Parasitol

authors

Scarcella S,Lamenza P,Virkel G,Solana H

doi

10.1016/j.molbiopara.2011.09.011

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

37-9

issue

1

eissn

0166-6851

issn

1872-9428

pii

S0166-6851(11)00223-4

journal_volume

181

pub_type

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