Energy metabolism in Cotugnia digonopora and the effect of anthelmintics.

Abstract:

:Incorporation of 32Pi into organic phosphate by mitochondria of Cotugnia digonopora was supported maximally by malate. Fumarate and succinate induced lower but significant production of ATP. Pyruvate, alpha-ketoglutarate and oxalacetate proved to be poor substrates and citrate and isocitrate had no effect. A net phosphorylation of approximately 2 mol of ADP was observed for each mol of CO2 liberated from malate or succinate. In contrast, with pyruvate, in spite of a high rate of decarboxylation, the production of ATP was extremely low. 2,4-Dinitrophenol inhibited phosphorylation. All anthelmintics examined interfered with the mitochondrial phosphorylation of ADP, with maximum inhibition by salicylanilide compounds. The anticestodal activity of the latter group of compounds, niclosamide for example, may, therefore, be attributed to their ability to inhibit mitochondrial phosphorylation.

journal_name

Mol Biochem Parasitol

authors

Pampori NA,Singh G,Srivastava VM

doi

10.1016/0166-6851(84)90066-5

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

205-13

eissn

0166-6851

issn

1872-9428

pii

0166-6851(84)90066-5

journal_volume

11

pub_type

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