Abstract:
:Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise-related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Tosetti M,Linsalata S,Battini R,Volpi L,Cini C,Presciutti O,Muntoni F,Cioni G,Siciliano Gdoi
10.1002/mus.22181subject
Has Abstractpub_date
2011-11-01 00:00:00pages
816-9issue
5eissn
0148-639Xissn
1097-4598journal_volume
44pub_type
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