Abstract:
:After industrial processing, one-third of sugarcane culms is converted into residual bagasse. The xylan-rich hemicellulose components of the bagasse were extracted with hot aqueous alkali (AX-CRUDE). Approximately 82% of the extracted hemicelluloses was precipitated with ethanol (AX-PET). Both AX-CRUDE and AX-PET contained an arabinoxylan as confirmed by 13C NMR and methylation analysis. Fraction AX-PET was fed to female Wistar rats with ethanol-induced gastric lesions. Oral administrations of 30, 100, and 300 mg/kg reduced the gastric lesion area by over 50%, and replenished ethanol-induced depletion of glutathione. The polysaccharide also increased mucus production by over 70%, indicating its cytoprotective action on experimentally induced gastric ulcers. These findings are significant, since a biologically active compound can be extracted in high yields from an abundant, readily available residue.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Mellinger-Silva C,Simas-Tosin FF,Schiavini DN,Werner MF,Baggio CH,Pereira IT,da Silva LM,Gorin PA,Iacomini Mdoi
10.1016/j.biortech.2011.08.107subject
Has Abstractpub_date
2011-11-01 00:00:00pages
10524-8issue
22eissn
0960-8524issn
1873-2976pii
S0960-8524(11)01217-Xjournal_volume
102pub_type
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