Isolation of a gastroprotective arabinoxylan from sugarcane bagasse.

Abstract:

:After industrial processing, one-third of sugarcane culms is converted into residual bagasse. The xylan-rich hemicellulose components of the bagasse were extracted with hot aqueous alkali (AX-CRUDE). Approximately 82% of the extracted hemicelluloses was precipitated with ethanol (AX-PET). Both AX-CRUDE and AX-PET contained an arabinoxylan as confirmed by 13C NMR and methylation analysis. Fraction AX-PET was fed to female Wistar rats with ethanol-induced gastric lesions. Oral administrations of 30, 100, and 300 mg/kg reduced the gastric lesion area by over 50%, and replenished ethanol-induced depletion of glutathione. The polysaccharide also increased mucus production by over 70%, indicating its cytoprotective action on experimentally induced gastric ulcers. These findings are significant, since a biologically active compound can be extracted in high yields from an abundant, readily available residue.

journal_name

Bioresour Technol

journal_title

Bioresource technology

authors

Mellinger-Silva C,Simas-Tosin FF,Schiavini DN,Werner MF,Baggio CH,Pereira IT,da Silva LM,Gorin PA,Iacomini M

doi

10.1016/j.biortech.2011.08.107

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

10524-8

issue

22

eissn

0960-8524

issn

1873-2976

pii

S0960-8524(11)01217-X

journal_volume

102

pub_type

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