Potential of thermophilic fungus Rhizomucor pusillus NRRL 28626 in biotransformation of antihelmintic drug albendazole.

Abstract:

:In the present investigation, thermophilic fungus Rhizomucor pusillus was used to study biotransformation of antihelmintic drug albendazole to produce its active metabolite, albendazole sulfoxide and novel metabolites of commercial interest. A two-stage fermentation procedure was followed for biotransformation of albendazole. The transformation was identified and structures were confirmed by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry analysis. Four metabolites albendazole sulfoxide, the active metabolite, albendazole sulfone, N-methyl metabolite of albendazole sulfoxide, and a novel metabolite were produced. The study demonstrates the biotransformation ability of thermophilic fungus R. pusillus NRRL28626 in the production of, the active metabolite of albendazole which has industrial and economic importance, other metabolites and a novel metabolite in an ecofriendly way.

authors

Prasad GS,Girisham S,Reddy SM

doi

10.1007/s12010-011-9329-5

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1120-8

issue

5-6

eissn

0273-2289

issn

1559-0291

journal_volume

165

pub_type

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