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The mature-parasite-infected erythrocyte surface antigen (MESA) of Plasmodium falciparum associates with the erythrocyte membrane skeletal protein, band 4.1.

Abstract：

:Several proteins synthesized by mature asexual stages of Plasmodium falciparum interact with the erythrocyte membrane skeleton. One of these is the mature-parasite-infected erythrocyte surface antigen (MESA; also called PfEMP2), a phosphoprotein of 250-300 kDa, which is found on the internal face of the erythrocyte membrane. When MESA is precipitated with anti-MESA antibodies, another phosphoprotein of 80 kDa is co-precipitated. This 80-kDa phosphoprotein was identified by peptide mapping as the erythrocyte membrane component band 4.1. Thus, MESA is apparently anchored at the erythrocyte membrane through an association with band 4.1. Band 4.1 is more intensely phosphorylated in infected erythrocytes and is increased in relative molecular mass in erythrocytes infected by isolates of P. falciparum that cytoadhere.

journal_name

Mol Biochem Parasitol

journal_title

Molecular and biochemical parasitology

authors

Lustigman S,Anders RF,Brown GV,Coppel RL

doi

10.1016/0166-6851(90)90029-l

subject

Has Abstract

pub_date

1990-01-15 00:00:00

pages

261-70

issue

2

eissn

0166-6851

issn

1872-9428

pii

0166-6851(90)90029-L

journal_volume

38

pub_type

杂志文章

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