Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: a pathway-based analysis.

abstract：:Altered c-Ha-ras genes have been frequently detected in the DNA of spontaneous or chemically induced mouse liver tumors. To determine if ras gene mutation is a frequent event during liver carcinogenesis in rats, we examined the transforming activity of DNA from liver tumors that developed in rats injected with methyl(...

journal_title：Molecular carcinogenesis

authors： Goyette M,Dolan M,Kaufmann W,Kaufman D,Shank PR,Fausto N

更新日期：1988-01-01 00:00:00

abstract：:Angelica gigas Nakai (AGN) root ethanol extract exerts anti-cancer activity in several allograft and xenograft models. Here we examined its chemopreventive efficacy through gavage administration against primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Male C57BL/6 TRAMP mice and...

journal_title：Molecular carcinogenesis

authors： Zhang J,Wang L,Zhang Y,Li L,Tang S,Xing C,Kim SH,Jiang C,Lü J

更新日期：2015-12-01 00:00:00

abstract：:The MN/CA9 (G250) gene expressed in the normal alimentary tract in a tissue-specific manner is often activated in renal cell carcinomas. To cast light on the activation mechanism, we examined the methylation status of this gene in seven human renal cell carcinoma cell lines (SKRC-01, -06, -10, -12, -14, -44, and -59) ...

journal_title：Molecular carcinogenesis

authors： Cho M,Grabmaier K,Kitahori Y,Hiasa Y,Nakagawa Y,Uemura H,Hirao Y,Ohnishi T,Yoshikawa K,Ooesterwijk E

更新日期：2000-03-01 00:00:00

abstract：:Formation of G4 DNA may occur in the course of replication and transcription, and contribute to genomic instability. We have quantitated abundance of G4 motifs and potential for G4 DNA formation of the nontemplate strand of 5' exons and introns of transcripts of human genes. We find that, for all human genes, G4 motif...

journal_title：Molecular carcinogenesis

authors： Eddy J,Maizels N

更新日期：2009-04-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:We found that caffeine significantly inhibited epidermal growth factor (EGF)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation in the JB6 mouse epidermal cell line. The tumor promoter-induced cell transformation was also blocked by treatment with an adenosine A1 receptor antagonist, 8-phenylt...

journal_title：Molecular carcinogenesis

authors： Nomura M,Ichimatsu D,Moritani S,Koyama I,Dong Z,Yokogawa K,Miyamoto K

更新日期：2005-09-01 00:00:00

abstract：:Using relatively primitive tools in the 1920s, Otto Warburg demonstrated that tumor cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not. High rates of glucose uptake, fueling glycolysis, are now used clinically to identify cancer cells. Ho...

journal_title：Molecular carcinogenesis

authors： Nakajima EC,Van Houten B

更新日期：2013-05-01 00:00:00

abstract：:To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the MDM-2 and p53 genes and genetic alterations in the p53 gene in five bladder carcinoma cell lines and one kidney urothelial carcinoma cell line. Overexpression of MDM-2 mRNA...

journal_title：Molecular carcinogenesis

authors： Cheng YT,Li YL,Wu JD,Long SB,Tzai TS,Tzeng CC,Lai MD

更新日期：1995-07-01 00:00:00

abstract：:Human DEAD-box RNA helicase gene DDX6 was cloned from B-cell lymphoma cell line RC-K8. Previously, we reported that DDX6 acts as oncogene in several cancers such as colorectal cancer and hepatocellular carcinoma. However, the detailed mechanism of DDX6 action in carcinogenesis is largely unknown. In this study, we exa...

journal_title：Molecular carcinogenesis

authors： Taniguchi K,Iwatsuki A,Sugito N,Shinohara H,Kuranaga Y,Oshikawa Y,Tajirika T,Futamura M,Yoshida K,Uchiyama K,Akao Y

更新日期：2018-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All-trans retinoic acid (ATRA) is the major physiologically active form of vitamin A, regulating expression of many genes. Disturbances of vitamin A metabolism are prevalent in some cancer cells. The main aim of this work was...

journal_title：Molecular carcinogenesis

authors： Bleul T,Rühl R,Bulashevska S,Karakhanova S,Werner J,Bazhin AV

更新日期：2015-09-01 00:00:00

abstract：:Aberrant microRNA (miRNA) expression is involved in tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC). Furthermore, expression of some miRNAs has been shown to be under epigenetic regulation. However, less is known regarding the role of miRNA methylation in NSCLC development or clinical ou...

journal_title：Molecular carcinogenesis

authors： Tan W,Gu J,Huang M,Wu X,Hildebrandt MA

更新日期：2015-06-01 00:00:00

abstract：:Experimentally induced models of breast carcinogenesis in the rat are widely used for studying the biology of breast cancer and for developing and evaluating cancer prevention and control strategies. However, very little is known about gene expression changes that are associated with experimentally induced mammary car...

journal_title：Molecular carcinogenesis

authors： Lu J,Pei H,Kaeck M,Thompson HJ

更新日期：1997-10-01 00:00:00

abstract：:Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may have a potential for cancer treatment and a clinical trial has been launched to test WA in treating melanoma. He...

journal_title：Molecular carcinogenesis

authors： Li W,Zhang C,Du H,Huang V,Sun B,Harris JP,Richardson Q,Shen X,Jin R,Li G,Kevil CG,Gu X,Shi R,Zhao Y

更新日期：2016-11-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with poor prognosis. And different individuals respond to the same drug differently. Increasing evidence has confirmed that metabolism reprogramming was involved in the drug sensitivity of tumor cells. However, the potential molecular mechanism of 5...

journal_title：Molecular carcinogenesis

authors： Cui Y,Yang D,Wang W,Zhang L,Liu H,Ma S,Guo W,Yao M,Zhang K,Li W,Zhang Y,Guan F

更新日期：2020-08-01 00:00:00

abstract：:The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration, regulating various cellular processes in...

journal_title：Molecular carcinogenesis

authors： Meneses-Morales I,Izquierdo-Torres E,Flores-Peredo L,Rodríguez G,Hernández-Oliveras A,Zarain-Herzberg Á

更新日期：2019-06-01 00:00:00

abstract：:Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer. ODC is a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determined O...

journal_title：Molecular carcinogenesis

authors： O'Brien TG,Guo Y,Visvanathan K,Sciulli J,McLaine M,Helzlsouer KJ,Watkins-Bruner D

更新日期：2004-10-01 00:00:00

abstract：:Human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase and is located on chromosome 5p15, a genomic region which was found to be associated with multiple cancer types. But no associations with colorectal cancer (CRC) have been reported until recently. Therefore, the purpose of t...

journal_title：Molecular carcinogenesis

authors： Hofer P,Baierl A,Bernhart K,Leeb G,Mach K,Micksche M,Gsur A

更新日期：2012-10-01 00:00:00

abstract：:Recent studies have implicated a role for midkine (MK) in cancer progression. This is based upon its structural homology with pleiotrophin, an angiogenic growth factor, and its ability to enhance fibrinolytic activity of bovine endothelial cells. To investigate whether MK plays a role in breast cancer, we examined MK ...

journal_title：Molecular carcinogenesis

authors： Chen Y,McKenzie KE,Aldaz CM,Sukumar S

更新日期：1996-11-01 00:00:00

abstract：:Elevation of the steady-state mRNA levels of glucose transporter and c-myc are among the earliest changes in gene expression observed after Ha-rasT24 stimulation of Rat-1 fibroblasts to enter the cell cycle. Since the expression of these genes may be the result of either increased cell proliferation or a specific resp...

journal_title：Molecular carcinogenesis

authors： Godwin AK,Lieberman MW

更新日期：1991-01-01 00:00:00

abstract：:Patulin (PAT), a present day major contaminant of commercial apple and apple products is reported to be carcinogenic, embryotoxic, and immunotoxic. While oral and inhalation are considered to be the most prevalent routes of exposure to this toxin, exposure through skin is now being extensively investigated. Our previo...

journal_title：Molecular carcinogenesis

authors： Alam S,Pal A,Kumar R,Dwivedi PD,Das M,Ansari KM

更新日期：2014-12-01 00:00:00

abstract：:Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as...

journal_title：Molecular carcinogenesis

authors： Kundu A,Quirit JG,Khouri MG,Firestone GL

更新日期：2017-01-01 00:00:00

abstract：:The cellular senescence program is controlled by multiple genetic pathways, one of which involves the regulation of telomerase and telomere shortening. The introduction of a normal human chromosome 3 into the human renal cell carcinoma cell line RCC23 caused repression of telomerase activity, progressive shortening of...

journal_title：Molecular carcinogenesis

authors： Horikawa I,Oshimura M,Barrett JC

更新日期：1998-06-01 00:00:00

abstract：:The human p53 gene, a putative tumor suppressor gene, has a polymorphism in amino acid residue 72. We recently developed a method of detecting codon 72 polymorphism in this gene by digestion of polymerase chain reaction-amplified DNA using an allele-specific restriction endonuclease. This polymorphism allows the ident...

journal_title：Molecular carcinogenesis

authors： Oka K,Ishikawa J,Bruner JM,Takahashi R,Saya H

更新日期：1991-01-01 00:00:00

abstract：:Heterocyclic amines present in cooked foods are known to produce colon tumors in F344 rats at a high incidence, indicating the possibility of involvement of ras gene activation in colon carcinogenesis in rats as in humans. We examined mutations at codons 12, 13, and 61 of the Ki-ras, Ha-ras, and N-ras genes by polymer...

journal_title：Molecular carcinogenesis

authors： Kakiuchi H,Ushijima T,Ochiai M,Imai K,Ito N,Yachi A,Sugimura T,Nagao M

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to test whether long-term ethanol consumption confers therapeutic resistance to human liver cancer patients infected with hepatitis B virus (HBV). Chronic ethanol-treated cells were established by consecutively culturing a human hepatocellular carcinoma cell line, Hep 3B, which contains integ...

journal_title：Molecular carcinogenesis

authors： Huang CS,Lee YR,Chen CS,Tu SH,Wang YJ,Lee CH,Chen LC,Chang HW,Chang CH,Chih-Ming S,Wu CH,Ho YS

更新日期：2010-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. As tumor metastasis is the leading cause of death in patients with CRC, it is important to elucidate the molecular mechanisms that drive CRC metastasis. Studies have shown a close relationship between Iroquois homeobox (IRX) family genes and...

journal_title：Molecular carcinogenesis

authors： Zhu Q,Wu Y,Yang M,Wang Z,Zhang H,Jiang X,Chen M,Jin T,Wang T

更新日期：2019-11-01 00:00:00

abstract：:Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A4 (LXA4 ) and resolvi...

journal_title：Molecular carcinogenesis

authors： Fedirko V,McKeown-Eyssen G,Serhan CN,Barry EL,Sandler RS,Figueiredo JC,Ahnen DJ,Bresalier RS,Robertson DJ,Anderson CW,Baron JA

更新日期：2017-08-01 00:00:00

abstract：:In this report we characterized the transcriptional regulation of the rat mdr1b gene by xenobiotics. The expression of this gene was increased in primary rat hepatocytes and in the H4-II-E hepatoma cell line by exposure to carcinogens such as aflatoxin B1, N-acetoxy-2-acetylaminofluorene, and methyl methanesulfonate. ...

journal_title：Molecular carcinogenesis

authors： Silverman JA,Hill BA

更新日期：1995-05-01 00:00:00

abstract：:We previously found that the T24 Ha-ras oncogene induces metastatic ability in NIH 3T3 cells and that this change depends on expression of the ras oncogene. As part of our studies on mechanisms by which ras may induce metastasis, we investigated expression and activity of two cysteine proteinases, cathepsin L (major e...

journal_title：Molecular carcinogenesis

authors： Chambers AF,Colella R,Denhardt DT,Wilson SM

更新日期：1992-01-01 00:00:00

abstract：:Centchroman (CC), a female oral contraceptive, has been shown to possess breast anti-cancer activities. Recently, we have shown CC-mediated antimetastatic effect through reversal of epithelial-to-mesenchymal transition (EMT) in breast cancer. The loss of tumor suppressor genes (TSGs) has been shown to promote EMT in b...

journal_title：Molecular carcinogenesis

authors： Khan S,Shukla S,Sinha S,Meeran SM

更新日期：2016-11-01 00:00:00