Transforming activity of DNA from rat liver tumors induced by the carcinogen methyl(acetoxymethyl)nitrosamine.

abstract：:Matrix metalloproteinases (MMPs) are elevated in patients with squamous cell carcinoma (SCC) over either the head and neck (HNSCC) or the esophagus (ESCC). Synchronous SCC with both HNSCC and ESCC predispose to worse survival. This study tested if serum MMP levels correlate with clinical features and predict survival ...

journal_title：Molecular carcinogenesis

authors： Wang WL,Chang WL,Yeh YC,Lee CT,Chang CY,Lin JT,Sheu BS

更新日期：2013-06-01 00:00:00

abstract：:Paclitaxel is the last choice for the treatment of advanced melanoma as a second-line chemotherapeutic agent, but there are still many cases of intrinsic resistance to paclitaxel in melanoma and the reasons that cause paclitaxel resistance remain unclear. Here, we identified that high expression of SRY-box transcripti...

journal_title：Molecular carcinogenesis

authors： Si X,Gao Z,Xu F,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active metabolites N-acetoxy-IQ or N-acetoxy-Me...

journal_title：Molecular carcinogenesis

authors： Nouso K,Bohr VA,Schut HA,Snyderwine EG

更新日期：1993-01-01 00:00:00

abstract：:Integrin alpha6beta4 is altered in many neoplastic cells, but no data exist to show this happens in esophageal neoplasms. To examine the expression of this integrin in rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine (NMBA), (alpha6 and beta4 expression was evaluated in normal esophageal epithelium, ...

journal_title：Molecular carcinogenesis

authors： Khare L,Sabourin CL,DeYoung BR,Wagner BA,Stoner GD

更新日期：1998-03-01 00:00:00

abstract：:High levels of the cell growth inhibitor transforming growth factor-beta1 (TGF-beta1) are often found in a variety of human cancers. However, the physiological significance of this overexpression depends on the availability of the biologically active form of TGF-beta1 within the extracellular matrix of the tumor micro...

journal_title：Molecular carcinogenesis

authors： Guda K,Claffey KP,Dong M,Nambiar PR,Rosenberg DW

更新日期：2003-05-01 00:00:00

abstract：:The molecular pathogenesis of papillary thyroid carcinoma (PTC) is largely attributed to chromosomal rearrangements and point mutations in genes within the MAPK pathway (i.e., BRAF and RAS). Despite KRAS being the 6th most frequently mutated gene for all cancers, the reported frequency in thyroid cancer is only 2%. Th...

journal_title：Molecular carcinogenesis

authors： Myers MB,McKim KL,Parsons BL

更新日期：2014-02-01 00:00:00

abstract：:The DNA repair gene Ku70 plays a key role in the DNA double strand break (DSB) repair system. Defects in DSB repair capacity can lead to genomic instability. We hypothesized that the Ku70 C-1310G polymorphism (rs2267437) was associated with risk of renal cell carcinoma (RCC). We genotyped the Ku70 C-1310G polymorphism...

journal_title：Molecular carcinogenesis

authors： Wang W,Pan X,Huo X,Yan F,Wang M,Wang D,Gao Y,Cao Q,Luo D,Qin C,Yin C,Zhang Z

更新日期：2012-10-01 00:00:00

abstract：:Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for adenocarcinoma development, understanding the mechanisms that predispose the esophageal mucosa to m...

journal_title：Molecular carcinogenesis

authors： Compton KR,Orringer MB,Beer DG

更新日期：1999-02-01 00:00:00

abstract：:The role of telomerase as an essential requirement for the neoplastic conversion of human cells has been controversial. In the model of conversion of normal human cells to cancer cells by the combination of simian virus 40 (SV40) early region genes and oncogenic Ras (H-Ras(G12V)), telomerase (hTERT) was originally des...

journal_title：Molecular carcinogenesis

authors： Liang S,Kahlenberg MS,Rousseau DL Jr,Hornsby PJ

更新日期：2008-06-01 00:00:00

abstract：:Neuroblastoma, the most common extracranial solid tumor in children, arises from precursors of the sympathetic nervous system. Neuroblastoma cell lines are responsive to the differentiation agent retinoic acid, which induces its effects by altering transcription rates of specific target genes. We identified autotaxin ...

journal_title：Molecular carcinogenesis

authors： Dufner-Beattie J,Lemons RS,Thorburn A

更新日期：2001-04-01 00:00:00

abstract：:The tyrosinase promoter has been used to target expression of the mutated human T24 Ha-ras oncogene in pigment-producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of mutated coat color, deeply pigmented skin with multiple nevi, and twi...

journal_title：Molecular carcinogenesis

authors： Powell MB,Hyman P,Bell OD,Balmain A,Brown K,Alberts D,Bowden GT

更新日期：1995-02-01 00:00:00

abstract：:In epithelial ovarian cancer, tumor grade is an independent prognosticator whose molecular determinants remain unknown. We investigated patterns of gene expression in well- and poorly differentiated serous papillary ovarian and peritoneal carcinomas with cDNA microarrays. A 6500-feature cDNA microarray was used for co...

journal_title：Molecular carcinogenesis

authors： Jazaeri AA,Lu K,Schmandt R,Harris CP,Rao PH,Sotiriou C,Chandramouli GV,Gershenson DM,Liu ET

更新日期：2003-02-01 00:00:00

abstract：:Apigenin (4',5,7-trihydroxyflavone), a flavone subclass of flavonoid widely distributed in many herbs, fruits, and vegetables is a substantial component of the human diet and has been shown to possess a variety of biological activities including tumor growth inhibition and chemoprevention. Recent studies in several bi...

journal_title：Molecular carcinogenesis

authors： Jeyabal PV,Syed MB,Venkataraman M,Sambandham JK,Sakthisekaran D

更新日期：2005-09-01 00:00:00

abstract：:Ras-mediated transformation is associated with upregulation of cyclooxygenase-2 (COX-2), which in turn promotes prostaglandin E2 (PGE2) synthesis and secretion. Although recent studies have identified molecular mechanisms by which Ras mediates upregulation of COX-2, conflicting observations have been made. Furthermore...

journal_title：Molecular carcinogenesis

authors： Repasky GA,Zhou Y,Morita S,Der CJ

更新日期：2007-12-01 00:00:00

abstract：:To study the possible involvement of DNA damage in cell transformation induced by estrogens, we examined whether DNA adduct formation is elicited in cultured Syrian hamster embryo (SHE) cells treated with estrogens and their derivatives by means of the 32P-postlabeling assay. Morphological transformation of the cells ...

journal_title：Molecular carcinogenesis

authors： Hayashi N,Hasegawa K,Komine A,Tanaka Y,McLachian JA,Barrett JC,Tsutsui T

更新日期：1996-07-01 00:00:00

abstract：:Adipose tissue dysregulation, a hallmark of obesity, contributes to a chronic state of low-grade inflammation and is associated with increased risk and progression of several breast cancer subtypes, including claudin-low breast tumors. Unfortunately, mechanistic targets for breaking the links between obesity-associate...

journal_title：Molecular carcinogenesis

authors： Rossi EL,Khatib SA,Doerstling SS,Bowers LW,Pruski M,Ford NA,Glickman RD,Niu M,Yang P,Cui Z,DiGiovanni J,Hursting SD

更新日期：2018-03-01 00:00:00

abstract：:The ubiquitin-proteasome pathway is fundamental to synchronized continuation of many cellular processes, for example, cell-cycle progression, stress response, and cell differentiation. Recent studies have shown that the ubiquitin-proteasome pathway functions in the regulation of nucleotide excision repair (NER) in yea...

journal_title：Molecular carcinogenesis

authors： Wang QE,Wani MA,Chen J,Zhu Q,Wani G,El-Mahdy MA,Wani AA

更新日期：2005-01-01 00:00:00

abstract：:Metformin, an oral biguanide for the treatment of type II diabetes, has been shown to have anticancer effects in ovarian cancer. Energy starvation induced by metformin causes endoplasmic reticulum stress-mediated unfolded protein response (UPR) and autophagy. UPR and autophagy act as a survival or death mechanism in c...

journal_title：Molecular carcinogenesis

authors： Moon HS,Kim B,Gwak H,Suh DH,Song YS

更新日期：2016-04-01 00:00:00

abstract：:Increased epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer (TNBC) is recognized as a promising therapeutic target, specifically through the use of selective EGFR inhibitors combined with chemotherapies. TNBC is characterized by genetic instability that leads to increased sensitivity ...

journal_title：Molecular carcinogenesis

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2017-05-01 00:00:00

abstract：:Increasing evidence from recent research suggests a connection between cancer and a deranged equilibrium of histone acetylation, which is maintained by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs). It is our hypothesis that a significant proportion of leukemias...

journal_title：Molecular carcinogenesis

authors： Mahlknecht U,Ottmann OG,Hoelzer D

更新日期：2000-04-01 00:00:00

abstract：:KITLG/KIT pathway plays a vital role in multiple types of human cancer including head and neck squamous cell carcinoma (HNSCC). Genetic variations in KITLG and KIT may affect the expression or function of these genes, thereby modifying cancer risk. In this study, we evaluated the association of KITLG and KIT polymorph...

journal_title：Molecular carcinogenesis

authors： Hang D,Yuan H,Liu L,Wang L,Miao L,Zhu M,Du J,Dai J,Hu Z,Chen N,Shen H,Ma H

更新日期：2017-01-01 00:00:00

abstract：:Prostate cancer (PCa) patients' mortality is mainly attributed to complications caused by metastasis of the tumor cells to organs critical for survival, such as bone. We hypothesized that PCa cell-bone interactions would promote paracrine signaling. A panel of PCa cell lines were cocultured with hydroxyapatite ([HA]; ...

journal_title：Molecular carcinogenesis

authors： Henderson VM,Hawsawi O,Burton LJ,Campbell T,Trice K,Dougan J,Howard SM,Odero-Marah VA

更新日期：2019-08-01 00:00:00

abstract：:Cytogenetic and molecular studies of human renal cell carcinoma (RCC) have suggested that the genetic and functional losses of one or more putative tumor suppressor genes on the short arm of chromosome 3 play a crucial role in the development of this disease. To examine whether the introduction of chromosome 3 has any...

journal_title：Molecular carcinogenesis

authors： Yoshida MA,Shimizu M,Ikeuchi T,Tonomura A,Yokota J,Oshimura M

更新日期：1994-03-01 00:00:00

abstract：:We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the Rheb/p27 axis in cancer cells remains unknown. Here, we show that siRNA-mediated depletion of Rheb decreases survival of human...

journal_title：Molecular carcinogenesis

authors： Campos T,Ziehe J,Palma M,Escobar D,Tapia JC,Pincheira R,Castro AF

更新日期：2016-02-01 00:00:00

abstract：:Atypical adenomatous hyperplasia (AAH) of the prostate is characterized by lobular proliferation of closely packed small acini. It is hypothesized that AAH is a precursor lesion for low-grade prostate cancer arising from the transition zone. Telomere dysfunction is common during malignant transformation of epithelia. ...

journal_title：Molecular carcinogenesis

authors： Cheng L,Montironi R,Davidson DD,Wang M,Lopez-Beltran A,Zhang S

更新日期：2019-07-01 00:00:00

abstract：:The presence of RD(INK4/ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such upregulation can be repressed through interactions between RD and oncoproteins CDC6 and BMI1, little is known abou...

journal_title：Molecular carcinogenesis

authors： Poi MJ,Knobloch TJ,Sears MT,Warner BM,Uhrig LK,Weghorst CM,Li J

更新日期：2015-07-01 00:00:00

abstract：:Adenocarcinoma accounts for ∼40% of lung cancer, equating to ∼88 500 new patients in 2015, most of who will succumb to this disease, thus, the public health burden is evident. Unfortunately, few early biomarkers as well as effective therapies exist, hence the need for novel targets in lung cancer treatment. We previou...

journal_title：Molecular carcinogenesis

authors： Bauer AK,Velmurugan K,Xiong KN,Alexander CM,Xiong J,Brooks R

更新日期：2017-01-01 00:00:00

abstract：:Krüppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types. Cells that sustain double strand breaks (DSBs) in their DNA due to high levels of reactive oxygen species (ROS) can develop genomic instability, which can result in cancer formation. On...

journal_title：Molecular carcinogenesis

authors： Liu C,La Rosa S,Hagos EG

更新日期：2015-09-01 00:00:00

abstract：:Diet-derived butyrate, a histone deacetylase inhibitor (HDI), decreases proliferation and increases apoptosis in colorectal cancer (CRC) cells via epigenetic changes in gene expression. Other HDIs such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) have similar effects. This study examined the role...

journal_title：Molecular carcinogenesis

authors： Humphreys KJ,Cobiac L,Le Leu RK,Van der Hoek MB,Michael MZ

更新日期：2013-06-01 00:00:00

abstract：:The cellular response to cisplatin involves activation of multiple signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways. In this study, we compared the cisplatin-induced activation of two MAP kinases, c-jun N-terminal kinase 1 (JNK1) and extracellular signal-regulated protein kin...

journal_title：Molecular carcinogenesis

authors： Cui W,Yazlovitskaya EM,Mayo MS,Pelling JC,Persons DL

更新日期：2000-12-01 00:00:00