Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China.

Abstract:

:The authors evaluated indoor air pollution from coal combustion (IAPCC) as a potential risk factor for neural tube defects (NTDs) in a rural population in Shanxi Province, China. The studied rural population has both high IAPCC exposure and a high prevalence of NTDs. A population-based case-control study was used to identify 610 NTD cases and 837 normal controls between November 2002 and December 2007. Information was collected within 1 week following delivery or pregnancy termination due to prenatal NTD diagnosis. The authors derived an exposure index by integrating a series of IAPCC-related characteristics concerning dwelling and lifestyle. Compared with women with no IAPCC exposure, women with any exposure at all had a 60% increased risk of having a child with an NTD (adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.1, 2.1). An increased NTD risk was linked to both residential heating (adjusted OR = 1.7, 95% CI: 1.1, 2.4) and cooking (adjusted OR = 1.5, 95% CI: 1.1, 2.1). The risk increased with increases in the exposure index, showing a dose-response trend (P < 0.001). This is the first known study to link IAPCC to NTDs. Additional studies are needed to confirm the link between IAPCC and NTDs.

journal_name

Am J Epidemiol

authors

Li Z,Zhang L,Ye R,Pei L,Liu J,Zheng X,Ren A

doi

10.1093/aje/kwr108

subject

Has Abstract

pub_date

2011-08-15 00:00:00

pages

451-8

issue

4

eissn

0002-9262

issn

1476-6256

pii

kwr108

journal_volume

174

pub_type

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