Increased detection of cystic-fibrosis-related diabetes in Australia.

Abstract:

OBJECTIVES:To estimate the incidence of cystic-fibrosis-related diabetes (CFRD) in youth from New South Wales (NSW) and the Australian Capital Territory (ACT), Australia and to examine demographic/clinical features at diagnosis. METHODS:Incident cases of CFRD in young people aged ≤ 18 years diagnosed during 2000 to 2008 were identified from four paediatric cystic fibrosis (CF) clinics and the NSW/ACT Australasian Paediatric Endocrine Group Diabetes Register. RESULTS:CFRD was diagnosed in 41 cases (59% girls). The estimated mean annual incidence of CFRD among patients with CF was 9.4 per 1000 person years (95% CI 6.8 to 12.8). Incidence increased from 2.0 per 1000 person years in 2000 to 22.1 per 1000 in 2008 (incidence RR 1.3, 95% CI 1.1 to 1.4). Haemoglobin A1c (HbA1c) was abnormal in the majority at diagnosis: median HbA1c was 6.9% (6.2-8.1%). More cases were diagnosed using an oral glucose tolerance test in 2007-2008 compared with previous years (61% vs 6%, p<0.001). CONCLUSIONS:CFRD is increasingly recognised and now affects approximately one in five young people with CF. The rising incidence is likely to be due to increased detection, resulting from greater awareness and changes in screening practices. Widespread uptake of consensus guidelines for screening will ensure accurate case detection, but will also impact on patient care and resource allocation.

journal_name

Arch Dis Child

authors

Rana M,Munns CF,Selvadurai HC,Simonds S,Cooper PJ,Woodhead HJ,Hameed S,Verge CF,Lafferty AR,Crock PA,Craig ME

doi

10.1136/adc.2010.208652

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

823-6

issue

9

eissn

0003-9888

issn

1468-2044

pii

adc.2010.208652

journal_volume

96

pub_type

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