Abstract:
:The pulmonary response to inhalation challenge with nebulised distilled water was measured in 100 sedated infants with a history of wheeze. Lung function was measured by total body plethysmography. Satisfactory results were obtained in 88 infants. Fifty one were considered to have responded by developing a greater than 20% decrease in specific conductance (sGaw) after nebulised water. Thirty two of these infants had previously been challenged with nebulised saline before but only one showed a greater than 20% decrease in sGaw after saline. Twenty infants who developed signs of bronchoconstriction after challenge with nebulised water were rechallenged 20 minutes later. After the initial challenge a fall in sGaw of greater than 20% was found in 19 of the 20. After a second challenge with nebulised water only 15 (75%) showed a 20% or greater decrease in sGaw. Nine of the 20 infants remained sedated and were rechallenged for a third time. Eight showed a greater than 20% decrease in sGaw. This study indicates that approximately 60% of infants with a history of wheeze will bronchoconstrict in response to inhaled nebulised water and that up to 75% show no evidence of a subsequent refractory period to inhaled water challenge.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
O'Callaghan C,Milner AD,Webb MS,Swarbrick Adoi
10.1136/adc.66.8.948subject
Has Abstractpub_date
1991-08-01 00:00:00pages
948-51issue
8eissn
0003-9888issn
1468-2044journal_volume
66pub_type
杂志文章abstract::Thirty-two children with a past diagnosis of coeliac disease were reinvestigated by means of gluten challenge. They had received a gluten-free diet for a mean period of 6-5 years (range 0-25-11-0) before gluten challenge, and had a mean age of 9-9 years (range 3-0-15-3) at the onset of challenge. Small intestinal biop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.6.449
更新日期:1978-06-01 00:00:00
abstract::We have studied changes in the birthweight of Asian babies born alive at this hospital between 1968 and 1978. In 1978 Pakistani babies were 139 g heavier but Indian babies only 25 g heavier than 10 years earlier. Contributing to these changes were significantly fewer short mothers and primiparae among Pakistanis, and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.11.867
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.114975
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To assess factors associated with granting of the Disability Living Allowance (DLA) for Down syndrome. DESIGN:Cross-sectional survey. SETTING:Families with a child with Down syndrome enrolled in a community-based trial of vitamin supplementation. PARTICIPANTS:156 children with trisomy 21 (59% male, 20% no...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.112839
更新日期:2008-01-01 00:00:00
abstract::Four children, including three infants, who died suddenly and unexpectedly are described. In three of the cases group A beta haemolytic streptococcus was cultured and in the fourth Streptococcus pneumoniae. The organism was grown from multiple sites including blood in two of them. Without microbiological investigation...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.3.381
更新日期:1993-09-01 00:00:00
abstract::Seventy infants with suspected bacterial infection in the first 48 hours of life were treated either with piperacillin and flucloxacillin or with penicillin and gentamicin. Infection was confirmed and successfully eradicated in 6 of the 35 infants receiving piperacillin and flucloxacillin. Four infants treated with pe...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.12.1006
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of subclinical deficits in cognitive and motor function in low birthweight infants. DESIGN:Children of birth weight < or = 2000 g born to mothers resident in Merseyside in 1980-1 assessed using the Wechsler Intelligence Scale for Children (WISC), the Neale analysis of reading abil...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.4.264
更新日期:1994-04-01 00:00:00
abstract::A volumetric Doppler technique was used to measure net ductus arteriosus shunt during the first 48 hours of life in 30 infants of less than 33 weeks' gestation, and in 10 full term infants. In the full term infants a left to right shunt of 62 ml/kg/minute (95% confidence limits 43-82) shortly after birth decreased rap...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.10.1030
更新日期:1987-10-01 00:00:00
abstract::The validation of measurement of cerebral blood volume (CBV) and cerebral blood flow (CBF) using near infrared spectroscopy (NIRS) against jugular venous occlusion plethysmography is described. Repeated measurements in six infants were made using both techniques simultaneously. A close relationship between the two mea...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.4_spec_no.407
更新日期:1992-04-01 00:00:00
abstract::Tuberculosis rarely presents in the neonatal period. Though treatable, it may be fatal despite modern treatment. The diagnosis of congenital tuberculosis should be considered in any neonate with pneumonia that fails to respond to conventional treatment, particularly in a child from an ethnic or socioeconomic environme...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.512
更新日期:1986-05-01 00:00:00
abstract:AIM:To determine the frequency of use of complementary treatment and measure its impact on clinical outcomes in a hospitalised general paediatric population. METHODS:A population based random sample of children admitted to the general paediatric service at a metropolitan children's hospital in Auckland, New Zealand fr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.2.133
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To develop a clinical algorithm to identify paediatric patients who should be offered HIV testing in a setting of moderate HIV prevalence and limited resources. METHODS:In a prospective cross-sectional study at Port Moresby General Hospital, Papua New Guinea, carers of inpatients were offered HIV testing and...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.179143
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. DESIGN:Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. SETTING:Six UK paediat...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/adc.2006.115493
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Adherence to attention-deficit/hyperactivity disorder (ADHD) medication treatment is often suboptimal. This can compromise patient outcomes. We aimed to describe the patterns of ADHD medication use in Australian children, and characteristics associated with patterns of use. DESIGN:Dispensing data were analys...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317997
更新日期:2020-06-01 00:00:00
abstract::Over 15 years, 42 children aged 2-14 years were diagnosed as having acquired aplastic anaemia. Adequate clinical details were available for 38 children who were categorised as very severe (n = 13), severe (n = 16), or nonsevere (n = 9) by the modified Camitta criteria. Treatment varied over the study period. Seven chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.7.858
更新日期:1991-07-01 00:00:00
abstract::A study was performed to compare adverse events and antibody response in term and preterm children vaccinated with diphtheria, tetanus, and pertussis vaccine at 2, 3, and 4 months of age. A total of 124 children were recruited and grouped according to gestational age: 37 weeks or more (n = 52), 34 to 36 weeks (n = 40)...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.3.230
更新日期:1995-03-01 00:00:00
abstract::Ninety-six Birmingham children with sickle cell disease were studied prospectively between 1969 and 1979. Thirty-five were homozygotes for HbS (SS), 12 had sickle thalassaemia (S thal), and 23 were double heterozygotes for HbS and C (SC). Twenty-six whose family studies were incomplete were classified as SS or S thal ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.9.676
更新日期:1981-09-01 00:00:00
abstract::The poor prognosis of patients with trisomy 13 has long been accepted and has been ascribed to brain and heart malformations. It has been suggested, however, that the long term survival is better than was previously thought and that cardiac surgery may be justified. This population based study reviews the incidence, a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.343
更新日期:1994-10-01 00:00:00
abstract::Albuminuria was studied in 40 diabetic children before and after a standardised exercise test, and also in 21 normal children; the results are expressed as geometric mean (95% range) of urine albumin:urine creatinine ratio (mg/mg). There was no significant difference between the mean resting albumin:creatinine ratio i...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.4.305
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVES:Silver-Russell syndrome (SRS) is an imprinted disorder characterised by intrauterine growth retardation, relative macrocephaly, failure to thrive, typical facial phenotype and frequent body asymmetry. Feeding difficulties are frequently noted, but no study described evolution of gastrointestinal signs during...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305864
更新日期:2015-04-01 00:00:00
abstract::Eithe low birthweight infants were studied for their metabolic and hormonal responses to intravenous alimentation when the caloric input was varied. The study was made during three consecutive 12-hour periods, when solutions of glucose, glucose and amino-acids, and glucose and amino-acid and lipids were successively i...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.7.499
更新日期:1979-07-01 00:00:00
abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.8.601
更新日期:1981-08-01 00:00:00
abstract::Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was campared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-d...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.50.5.387
更新日期:1975-05-01 00:00:00
abstract:UNLABELLED:One hundred and seventy three children, including 93 with biliary atresia, received liver grafts at Addenbrooke's Hospital between 1983 and 1993. Of these, only seven developed cyanosis due to intrapulmonary shunting as a complication of their liver disease, and all seven of these had the biliary atresia/pol...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.6.501
更新日期:1994-06-01 00:00:00
abstract::Twenty six children with hypoglycaemia were diagnosed and followed between 1975 and 1995. Diagnosis was confirmed by a high insulin:glucose ratio, and low free fatty acid and 3-hydroxybutyrate on fasting. All patients were treated with diazoxide at a maximum dose of 20 mg/kg/day. Requirement of a higher dose was consi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.5.440
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on the validated Gorelick Scales. DESIGN, SETTING AND PATIENTS:Prospective unblinded study from April 2016 to February 2017 in a paediatric emergency department. Patients aged 1 month to...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-318425
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Timing of referral to subspecialists may be a major determinant for access to adequate treatment. Kidney transplantation is the preferred modality of renal replacement therapy (RRT) in children. In adults, delayed referral from general physicians to nephrologists reduced access to kidney transplantation. Thi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.174581
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Perinatal stress is thought to underlie the Barker sequelae of low birth weight, of which precocious pubarche may be a manifestation. AIMS:To explore whether prematurity as well as smallness for gestational age (SGA) predisposes to precocious pubarche, and the potential role of excess weight gain during chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.053959
更新日期:2005-03-01 00:00:00
abstract:AIMS:Out-of-hospital sudden cardiac arrest (SCA) is a rare but devastating event in children and adolescents. The risk is assumed to be higher in children with congenital heart defects (CHDs) than in healthy individuals. The aim of the present study was to investigate the rate of and survival after out-of-hospital card...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312621
更新日期:2018-01-01 00:00:00
abstract::The relation between intraventricular haemorrhage (IVH) and hyaline membrane disease (HMD) was studied in singletons that came to necropsy at Hammersmith Hospital over the years 1966-73. The incidence of IVH in singleton live births was 3-22/1000 and of HMD 4-44/1000. Although the high figures were partily due to the ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.10.755
更新日期:1976-10-01 00:00:00