Doxacurium and mivacurium do not trigger malignant hyperthermia in susceptible swine.

Abstract:

:The role of succinylcholine in the precipitation of malignant hyperthermia (MH) necessitates the testing of new neuromuscular relaxants for their ability to trigger MH in MH-susceptible swine before general human use. We tested doxacurium and mivacurium, two new nondepolarizing bis-benzylisoquinolinium neuromuscular relaxants, at ED95 and at four times ED95 doses in swine previously documented to be MH-susceptible. In none of the 16 animals was MH triggered after administration of these relaxants, whereas all animals developed fatal MH after administration of halothane or halothane plus succinylcholine. Muscle biopsy specimens taken before administration of the relaxant confirmed that all animals had increased sensitivity to halothane, caffeine, or both. Thus, we conclude that doxacurium and mivacurium are not triggering agents of malignant hyperthermia in MH-susceptible swine.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Sufit RL,Kreul JF,Bellay YM,Helmer P,Brunson DB,Will J

doi

10.1213/00000539-199009000-00012

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

285-7

issue

3

eissn

0003-2999

issn

1526-7598

journal_volume

71

pub_type

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