Complement activation and cardiac surgery: a novel target for improving outcomes.

Abstract:

:Complement activation and the resulting inflammatory response is an important potential mechanism for multisystem organ injury in cardiac surgery. Novel therapeutic strategies using complement inhibitors may hold promise for improving outcomes for cardiac surgical patients by attenuating complement activation or its biologically active effector molecules. Recent clinical trials evaluating complement inhibitors have provided important data to further delineate the impact of complement activation and its inhibition on clinical outcomes. In this review we examine the role of complement activation and its inhibition as a therapeutic approach in cardiac surgery.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Stahl GL,Shernan SK,Smith PK,Levy JH

doi

10.1213/ANE.0b013e3182652b7d

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

759-71

issue

4

eissn

0003-2999

issn

1526-7598

pii

ANE.0b013e3182652b7d

journal_volume

115

pub_type

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