Abstract:
:The clinical and preclinical use of high-field intensity (HF, 3 T and above) magnetic resonance imaging (MRI) scanners have significantly increased in the past few years. However, potential health risks are implied in the MRI and especially HF MRI environment due to high-static magnetic fields, fast gradient magnetic fields, and strong radiofrequency electromagnetic fields. In this study, the genotoxic potential of 3 T clinical MRI scans in cultured human lymphocytes in vitro was investigated by analyzing chromosome aberrations (CA), micronuclei (MN), and single-cell gel electrophoresis. Human lymphocytes were exposed to electromagnetic fields generated during MRI scanning (clinical routine brain examination protocols: three-channel head coil) for 22, 45, 67, and 89 min. We observed a significant increase in the frequency of single-strand DNA breaks following exposure to a 3 T MRI. In addition, the frequency of both CAs and MN in exposed cells increased in a time-dependent manner. The frequencies of MN in lymphocytes exposed to complex electromagnetic fields for 0, 22, 45, 67, and 89 min were 9.67, 11.67, 14.67, 18.00, and 20.33 per 1000 cells, respectively. Similarly, the frequencies of CAs in lymphocytes exposed for 0, 45, 67, and 89 min were 1.33, 2.33, 3.67, and 4.67 per 200 cells, respectively. These results suggest that exposure to 3 T MRI induces genotoxic effects in human lymphocytes.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Lee JW,Kim MS,Kim YJ,Choi YJ,Lee Y,Chung HWdoi
10.1002/bem.20664subject
Has Abstractpub_date
2011-10-01 00:00:00pages
535-42issue
7eissn
0197-8462issn
1521-186Xjournal_volume
32pub_type
杂志文章abstract::The effects of exposure to clinical magnetic resonance imaging (MRI) on analgesia induced by the mu opiate agonist, fentanyl, was examined in mice. During the dark period, adult male mice were exposed for 23.2 min to the time-varying (0.6 T/sec) magnetic field (TVMF) component of the MRI procedure. Following this expo...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250090208
更新日期:1988-01-01 00:00:00
abstract::A number of studies have shown that power frequency magnetic fields may affect spatial memory functions in rodents. An experiment was performed using a spontaneous object recognition task to investigate if nonspatial working memory was similarly affected. Memory changes in adult, male C57BL/6J mice were assessed by me...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250040109
更新日期:1983-01-01 00:00:00
abstract::Measurements have been made of vector current densities induced by vertical, uniform, 60-Hz electric fields in the torsos of homogeneous models of swine and rats. The observed data were a strong function of the five grounding configurations invested: all four feet grounded, only front feet grounded, only rear feet gro...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250090102
更新日期:1988-01-01 00:00:00
abstract::Cultures of Escherichia coli kept at 0 degree C in a phosphate buffer solution were exposed to a sinusoidal weak 60- or 600-Hz magnetic field of strength 2 X 10(-3) Tesla. A decrease of more than 40% in bacterial count was observed after a 60-h exposure to the magnetic field. Electron micrographs of exposed bacteria s...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250020310
更新日期:1981-01-01 00:00:00
abstract::We present a simple readout device that fills the void produced by the gradual disappearance of the Vitck model 101 Electrothermia Monitor. The new device uses commercially available probes that are similar to Bowman's (IEEE Trans Microwave Theory Tech MTT-24:43-45, 1976) original design. As described, the device cove...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250100210
更新日期:1989-01-01 00:00:00
abstract::The Minnesota Environmental Quality Board completed a 3-year study of the space charge plume outside the right of way of a bipolar (+/- 400 kV) direct current transmission line in rural west central Minnesota. The purpose of the study was to determine the levels of DC potential gradient and small airs ions in the down...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250070404
更新日期:1986-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
doi:10.1002/bem.20126
更新日期:2005-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20235
更新日期:2006-10-01 00:00:00
abstract::Data are presented on ankle-specific SARs and foot currents as a function of strengths of radio-frequency electromagnetic fields encountered by operators of dielectric heaters. The determination of foot currents was based on near-field exposures in which reactive coupling dominates, and which can result in substantial...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250130204
更新日期:1992-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20494
更新日期:2009-09-01 00:00:00
abstract::The objective of the study was to investigate the influence of humidity on analyzing electric field exposure using extremely low frequency (ELF) electric field measurements. The study included 322 measurements in a climate room. We used two commercial three-axis meters, EFA-3 and EFA-300, and employed two measurement ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21776
更新日期:2013-07-01 00:00:00
abstract::The effects of millimeter microwaves in the frequency range of 54-76 GHz on capacitance and conductance of lipid bilayer membranes (BLM) were studied. Some of the membranes were modified by gramicidin A and amphotericin B or by tetraphenylboron anions (TPhB-). The millimeter microwaves were pulse-modulated (PW) at rep...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160209
更新日期:1995-01-01 00:00:00
abstract::Effects of short, extremely high power microwave pulses (EHPP) on neuronal network function were explored by electrophysiological techniques in the isolated rat hippocampal slice model. Population spikes (PS) in the CA1 area were evoked by repeated stimulation (1 per 30 s) of the Schaffer collateral pathway. A brief t...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.10079
更新日期:2003-04-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Findings from prior studies of possible health and physiological effects from mobile phone use have been inconsistent. Exposure periods in provocation studies have been rather short and personal characteristics of the participants poorly defined. We studied the effect of radiofrequency field (RF) on self-reported symp...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20379
更新日期:2008-04-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20013
更新日期:2004-09-01 00:00:00
abstract::Studies have evaluated the electroencephalography (EEG) of humans and laboratory animals during and after Radiofrequency (RF) exposures. Effects of RF exposure on the blood-brain barrier (BBB) have been generally accepted for exposures that are thermalizing. Low level exposures that report alterations of the BBB remai...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
doi:10.1002/bem.10179
更新日期:2003-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(sici)1521-186x(1997)18:3<223::aid-bem4>3.
更新日期:1997-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.10122
更新日期:2003-09-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20251
更新日期:2006-12-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250090402
更新日期:1988-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 评论,杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.10120
更新日期:2003-10-01 00:00:00
abstract::Pulsed electromagnetic fields (PEMF) have been proven to be effective for promoting bone mass and regulating bone turnover both experimentally and clinically. However, the exact mechanisms for the regulation of PEMF on osteoclastogenesis as well as optical exposure parameters of PEMF on inhibiting osteoclastic activit...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.22070
更新日期:2017-12-01 00:00:00
abstract::One hundred subjects, males and females with ages ranging between 18 and 48 years, were studied under both field-exposed and sham-exposed conditions. A 50 Hz, 100 mu T magnetic field (MF) was used. To examine the effect of field exposure on performance, a two-alternative, forced-choice, duration-discrimination task wi...
journal_title:Bioelectromagnetics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(SICI)1521-186X(1996)17:2<131::AID-BEM7>3.
更新日期:1996-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250050302
更新日期:1984-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250060406
更新日期:1985-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250050109
更新日期:1984-01-01 00:00:00
abstract::The controversy over the possible association between magnetic field exposure and childhood leukemia has led several researchers to summarize the literature using meta-analysis. This paper reviews these previous meta-analyses and extends them by adding results from four studies published since the most recent analysis...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,meta分析
doi:10.1002/1521-186x(2001)22:5+<::aid-bem1026>3.3.co;
更新日期:2001-01-01 00:00:00