Abstract:
:The objective of this study was to develop a model for testing various hypotheses concerning possible mechanisms whereby electromagnetic fields might induce suppression of nighttime melatonin production in rodents. A published method for digesting freshly obtained pineal glands to the single cell level was modified, yielding better than 95% viability. An in vitro exposure facility developed for the Food and Drug Administration was used for 12-h overnight exposures of primary pinealocyte cultures to 0.05 mT, 60 Hz, vertical AC and 0.06 microT, DC fields. After exposure, cells were separated from the supernatant by centrifugation. Supernatant melatonin was measured by ELISA assays. Data from 10 experiments demonstrated an average 46% reduction in norepinephrine-induced production of melatonin in the pinealocytes. The results support the hypothesis that EM exposure can produce pineal gland melatonin suppression by affecting individual cells.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Rosen LA,Barber I,Lyle DBsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
123-7issue
2eissn
0197-8462issn
1521-186Xpii
10.1002/(SICI)1521-186X(1998)19:2<123::AID-BEM11>3journal_volume
19pub_type
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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journal_title:Bioelectromagnetics
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