Effects of high power microwave pulses on synaptic transmission and long term potentiation in hippocampus.

Abstract:

:Effects of short, extremely high power microwave pulses (EHPP) on neuronal network function were explored by electrophysiological techniques in the isolated rat hippocampal slice model. Population spikes (PS) in the CA1 area were evoked by repeated stimulation (1 per 30 s) of the Schaffer collateral pathway. A brief tetanus (2 s at 50 Hz) was used to induce long term potentiation (LTP) of synaptic transmission. In three different series of experiments with a total of 160 brain slices, the EHPP irradiation was performed before, during, or after the tetanus. The EHPP carrier frequency was 9.3 GHz, the pulse width and repetition rate were from 0.5 to 2 micros and from 0.5 to 10 Hz, respectively, and the peak specific absorption rate (SAR) in brain slices reached up to 500 MW/kg. Microwave heating of the preparation ranged from 0.5 degrees C (at 0.3 kW/kg time average SAR) to 6 degrees C (at 3.6 kW/kg). The experiments established that the only effect caused by EHPP exposure within the studied range of parameters was a transient and fully reversible decrease in the PS amplitude. Recovery took no more than a few minutes after the cessation of exposure and return to the initial temperature. This effect's features were characteristic of an ordinary thermal response: it was proportional to the temperature rise but not to any specific parameter of EHPP, and it could also be induced by a continuous wave (CW) irradiation or conventional heating. Irradiation did not affect the ability of neurons to develop LTP in response to tetanus or to retain the potentiated state that was induced before irradiation. No lasting or delayed effects of EHPP were observed. The results are consistent with the thermal mechanism of EHPP action and thus far provided no indication of EHPP-specific effects on neuronal function.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Pakhomov AG,Doyle J,Stuck BE,Murphy MR

doi

10.1002/bem.10079

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

174-81

issue

3

eissn

0197-8462

issn

1521-186X

journal_volume

24

pub_type

杂志文章
  • Contact current hypothesis: summary of results to date.

    abstract::Research conducted over the past 5 years has addressed the hypothesis that the reported association between residential magnetic fields and childhood leukemia may be explained by exposure to contact current. The use of multi-grounded neutrals in electrical distribution and residential electrical wiring systems in the ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/bem.20126

    authors: Kavet R

    更新日期:2005-01-01 00:00:00

  • Acute effects of 50 Hz magnetic field exposure on human visual task and cardiovascular performance.

    abstract::One hundred subjects, males and females with ages ranging between 18 and 48 years, were studied under both field-exposed and sham-exposed conditions. A 50 Hz, 100 mu T magnetic field (MF) was used. To examine the effect of field exposure on performance, a two-alternative, forced-choice, duration-discrimination task wi...

    journal_title:Bioelectromagnetics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(SICI)1521-186X(1996)17:2<131::AID-BEM7>3.

    authors: Whittington CJ,Podd JV,Rapley BR

    更新日期:1996-01-01 00:00:00

  • Carcinogenicity test in B6C3F1 mice after parental and prenatal exposure to 50 Hz magnetic fields.

    abstract::Some epidemiological studies suggest association of childhood cancer with occupational exposure of the parents to magnetic fields. To test this relationship, 50 each of C57BL/6J female and C3H/HeJ male mice were exposed for 2 and 9 weeks, respectively, to 50 Hz sham (group A), 0.5 (group B), and 5 mT (group C) sinusoi...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10012

    authors: Otaka Y,Chida T,Yamagishi Y,Kitamura S

    更新日期:2002-04-01 00:00:00

  • Specific absorption rate in rats exposed to 2,450-MHz microwaves under seven exposure conditions.

    abstract::Both positive and negative biological effects of microwaves on drug actions in rats exposed to 1-mW/cm2, 2,450-MHz microwaves have been reported by several investigators. We conducted dosimetry studies for seven different exposure conditions to determine whether these different results could be due to the rats having ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250060108

    authors: Chou CK,Guy AW,McDougall JA,Lai H

    更新日期:1985-01-01 00:00:00

  • Low-Frequency Magnetic Fields in Cars and Office Premises and the Geomagnetic Field Variations.

    abstract::In this study, we measured and analyzed the spectral characteristics of a low-frequency magnetic field (MF) inside several gasoline-powered cars while driving on busy city roads. The spectra obtained upon measurements in the interior of the cars are compared with those measured in office locations at different times o...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22269

    authors: Sarimov R,Binhi V

    更新日期:2020-07-01 00:00:00

  • High-voltage overhead power lines in epidemiology: patterns of time variations in current load and magnetic fields.

    abstract::In epidemiological studies of electromagnetic fields and health effects, exposure classification is crucial. There is no generally accepted biophysical interaction mechanism, but many studies are based on the hypothesis of a causal relationship with the strength of magnetic field. Some definition of the magnitude of e...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-186X(1996)17:3<209::AID-BEM6>3.

    authors: Reitan JB,Tynes T,Kvamshagen KA,Vistnes AI

    更新日期:1996-01-01 00:00:00

  • Response of perennial woody plants to seed treatment by electromagnetic field and low-temperature plasma.

    abstract::Radiofrequency (5.28 MHz) electromagnetic radiation and low-temperature plasma were applied as short-term (2-15 min) seed treatments to two perennial woody plant species, including Smirnov's rhododendron (Rhododendron smirnowii Trautv.) and black mulberry (Morus nigra L.). Potential effects were evaluated using germin...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22003

    authors: Mildaziene V,Pauzaite G,Malakauskiene A,Zukiene R,Nauciene Z,Filatova I,Azharonok V,Lyushkevich V

    更新日期:2016-12-01 00:00:00

  • Microwave effects on the nervous system.

    abstract::Studies have evaluated the electroencephalography (EEG) of humans and laboratory animals during and after Radiofrequency (RF) exposures. Effects of RF exposure on the blood-brain barrier (BBB) have been generally accepted for exposures that are thermalizing. Low level exposures that report alterations of the BBB remai...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/bem.10179

    authors: D'Andrea JA,Chou CK,Johnston SA,Adair ER

    更新日期:2003-01-01 00:00:00

  • Effects of a 50 Hz sinusoidal magnetic field on cell adhesion molecule expression in two human osteosarcoma cell lines (MG-63 and Saos-2).

    abstract::The possibility that a sinusoidal 50 Hz magnetic field with a magnetic flux density of 0.5 mT can induce variations in the expression of cell adhesion molecules (CAMs) in two human osteosarcoma cell lines (MG-63 and Saos-2) was investigated. In particular, the expression of two important integrins, VLA-2, the receptor...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10113

    authors: Santini MT,Rainaldi G,Ferrante A,Indovina PL,Vecchia P,Donelli G

    更新日期:2003-07-01 00:00:00

  • Enhanced absorption of millimeter wave energy in murine subcutaneous blood vessels.

    abstract::The aim of the present study was to determine millimeter wave (MMW) absorption by blood vessels traversing the subcutaneous fat layer of murine skin. Most calculations were performed using the finite-difference time-domain (FDTD) technique. We used two types of models: (1) a rectangular block of multilayer tissue with...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20658

    authors: Alekseev SI,Ziskin MC

    更新日期:2011-09-01 00:00:00

  • Exposure to time varying magnetic fields associated with magnetic resonance imaging reduces fentanyl-induced analgesia in mice.

    abstract::The effects of exposure to clinical magnetic resonance imaging (MRI) on analgesia induced by the mu opiate agonist, fentanyl, was examined in mice. During the dark period, adult male mice were exposed for 23.2 min to the time-varying (0.6 T/sec) magnetic field (TVMF) component of the MRI procedure. Following this expo...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250090208

    authors: Teskey GC,Prato FS,Ossenkopp KP,Kavaliers M

    更新日期:1988-01-01 00:00:00

  • Analysis of individual- and school-level clustering of power frequency magnetic fields.

    abstract::This study reports the continuous 8-h monitoring of data on extremely low-frequency magnetic fields (ELF-MF) relating to 14 children and 35 teachers in 11 elementary schools in Northern Taiwan. It was anticipated that the subjects in two of these campuses would have elevated exposure to ELF-MF as a result of their clo...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20431

    authors: Lin IF,Li CY,Wang JD

    更新日期:2008-10-01 00:00:00

  • Intracellular calcium activity in isolated bovine adrenal chromaffin cells in the presence and absence of 60 Hz magnetic fields.

    abstract::This study examined whether 60 Hz magnetic field (MF) exposure alters intracellular calcium levels ([Ca(2+)](i)) in isolated bovine adrenal chromaffin cells, a classic model of neural responses. [Ca(2+)](i) was monitored by fluorescence video imaging of cells loaded with the calcium indicator fluo-4 during exposures t...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10045

    authors: Craviso GL,Poss J,Lanctot C,Lundback SS,Chatterjee I,Publicover NG

    更新日期:2002-12-01 00:00:00

  • Magnetic-field-induced vertigo: a theoretical and experimental investigation.

    abstract::Vertigo-like sensations or apparent perception of movement are reported by some subjects and operators in and around high field whole body magnetic resonance body scanners. Induced currents (which modulate the firing rate of the vestibular hair cell), magneto-hydrodynamics (MDH), and tissue magnetic susceptibility dif...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20316

    authors: Glover PM,Cavin I,Qian W,Bowtell R,Gowland PA

    更新日期:2007-07-01 00:00:00

  • Magnetic field therapy in patients with cytostatics-induced polyneuropathy: A prospective randomized placebo-controlled phase-III study.

    abstract::No causal treatment for chemotherapy-induced peripheral neuropathy (CIPN) is known. Therefore, there is an urgent need to develop a therapy for CIPN. Only scarce clinical data are available concerning magnetic field therapy (MFT) in this context. We conducted a unicentric, randomized, double-blind, placebo-controlled ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/bem.22005

    authors: Rick O,von Hehn U,Mikus E,Dertinger H,Geiger G

    更新日期:2017-02-01 00:00:00

  • Thermal action of 2.45 GHz microwaves on the cytoplasm of Chinese hamster cells.

    abstract::In order to demonstrate possible specific effects of microwaves at the cellular level V-79 Chinese hamster cells were exposed to 2.45-GHz radiation at power levels of 20-200 mW/cm2 and at specific absorption rates of 10-100 mW/g. Intracellular cytoplasmic changes were observed by fluorescence polarization using a meth...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250050212

    authors: Dardalhon M,Moré C,Averbeck D,Berteaud AJ

    更新日期:1984-01-01 00:00:00

  • Real-time measurement of cytosolic free calcium concentration in Jurkat cells during ELF magnetic field exposure and evaluation of the role of cell cycle.

    abstract::Extremely low frequency magnetic fields (ELF MF) have been reported to alter a number of cell signaling pathways, including those involved in proliferation, differentiation and apoptosis where cytosolic free calcium ([Ca(2+)](c)) plays an important role. To better understand the biological conditions under which ELF M...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20248

    authors: McCreary CR,Dixon SJ,Fraher LJ,Carson JJ,Prato FS

    更新日期:2006-07-01 00:00:00

  • Radiation from mobile phone systems: Is it perceived as a threat to people's health?

    abstract::The aim of this study was to explore the prevalence, nature and determinants of concerns about mobile phone radiation. We used data from a 2006 telephone survey of 1004 people aged 15+ years in Denmark. Twenty-eight percent of the respondents were concerned about exposure to mobile phone radiation; radiation from mast...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20484

    authors: Kristiansen IS,Elstein AS,Gyrd-Hansen D,Kildemoes HW,Nielsen JB

    更新日期:2009-07-01 00:00:00

  • Continuous exposure to 60 Hz magnetic fields induces duration- and dose-dependent apoptosis of testicular germ cells.

    abstract::To evaluate duration- and dose-dependent effects of continuous exposure to a 60 Hz magnetic field (MF) on the testes in mice, BALB/c male mice were exposed to a 60 Hz MF at 100 μT for 24 h a day for 2, 4, 6, or 8 weeks, and at 2, 20, or 200 μT for 24 h a day for 8 weeks. Any exposures to MF did not significantly affec...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.21819

    authors: Kim HS,Park BJ,Jang HJ,Ipper NS,Kim SH,Kim YJ,Jeon SH,Lee KS,Lee SK,Kim N,Ju YJ,Gimm YM,Kim YW

    更新日期:2014-02-01 00:00:00

  • Effect of short duration electromagnetic field exposures on rat mass.

    abstract::Daily preexposure and postexposure mass measurements of 65 rats (young males and females, old males) a proprietary pulsed wound healing field, pulsed electromagnetic field, (PEMF), or their control fields for 4 h/day for 21 days. Statistical analysis of mass changes over time showed that young rats exposed to PEMF los...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.92

    authors: Sandrey MA,Vesper DN,Johnson MT,Nindl G,Swez JA,Chamberlain J,Balcavage WX

    更新日期:2002-01-01 00:00:00

  • A model for radiofrequency electromagnetic field predictions at outdoor and indoor locations in the context of epidemiological research.

    abstract::We present a geospatial model to predict the radiofrequency electromagnetic field from fixed site transmitters for use in epidemiological exposure assessment. The proposed model extends an existing model toward the prediction of indoor exposure, that is, at the homes of potential study participants. The model is based...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20552

    authors: Bürgi A,Frei P,Theis G,Mohler E,Braun-Fahrländer C,Fröhlich J,Neubauer G,Egger M,Röösli M

    更新日期:2010-04-01 00:00:00

  • Time trends (1998-2007) in brain cancer incidence rates in relation to mobile phone use in England.

    abstract::Mobile phone use in the United Kingdom and other countries has risen steeply since the early 1990's when the first digital mobile phones were introduced. There is an ongoing controversy about whether radio frequency (RF) exposure from mobile phones increases the risk of brain cancer. However, given the widespread use ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20648

    authors: de Vocht F,Burstyn I,Cherrie JW

    更新日期:2011-07-01 00:00:00

  • A Lorentz model for weak magnetic field bioeffects: part I--thermal noise is an essential component of AC/DC effects on bound ion trajectory.

    abstract::We have previously employed the Lorentz-Langevin model to describe the effects of weak exogenous magnetic fields via the classical Lorentz force on a charged ion bound in a harmonic oscillator potential, in the presence of thermal noise forces. Previous analyses predicted that microT-range fields give rise to a rotati...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20494

    authors: Muehsam DJ,Pilla AA

    更新日期:2009-09-01 00:00:00

  • A numerical and experimental comparison of human head phantoms for compliance testing of mobile telephone equipment.

    abstract::A new human head phantom has been proposed by CENELEC/IEEE, based on a large scale anthropometric survey. This phantom is compared to a homogeneous Generic Head Phantom and three high resolution anatomical head models with respect to specific absorption rate (SAR) assessment. The head phantoms are exposed to the radia...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20088

    authors: Christ A,Chavannes N,Nikoloski N,Gerber HU,Poković K,Kuster N

    更新日期:2005-02-01 00:00:00

  • Effects of 1.8 GHz radiofrequency field on microstructure and bone metabolism of femur in mice.

    abstract::To investigate the effects of 1.8 GHz radiofrequency (RF) field on bone microstructure and metabolism of femur in mice, C57BL/6 mice (male, age 4 weeks) were whole-body exposed or sham exposed to 1.8 GHz RF field. Specific absorption rates of whole body and bone were approximately 2.70 and 1.14 W/kg (6 h/day for 28 da...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22125

    authors: Guo L,Zhang JP,Zhang KY,Wang HB,Wang H,An GZ,Zhou Y,Meng GL,Ding GR

    更新日期:2018-07-01 00:00:00

  • In vitro effect of pulsed 900 MHz GSM radiation on mitochondrial membrane potential and motility of human spermatozoa.

    abstract::Ejaculated, density purified, human spermatozoa were exposed to pulsed 900 MHz GSM mobile phone radiation at two specific absorption rate levels (SAR 2.0 and 5.7 W/kg) and compared with controls over time. Change in sperm mitochondrial membrane potential was analysed using flow cytometry. Sperm motility was determined...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20390

    authors: Falzone N,Huyser C,Fourie F,Toivo T,Leszczynski D,Franken D

    更新日期:2008-05-01 00:00:00

  • Pulsed subcutaneous electrical stimulation in spinal cord injury: preliminary results.

    abstract::The treatment of long-term, stable para- and quadriplegics with pulsed electrical stimulation for pain control resulted in, anecdotally, a significant number of these individuals showing increased motor function as well as sensory awareness. This small pilot study was conducted in order to assess the hypothesis that p...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250080206

    authors: Ellis W

    更新日期:1987-01-01 00:00:00

  • Low intensity magnetic field influences short-term memory: A study in a group of healthy students.

    abstract::This study analyzes if an external magnetic stimulus (2 kHz and approximately 0.1 μT applied near frontal cortex) influences working memory, perception, binary decision, motor execution, and sustained attention in humans. A magnetic stimulus and a sham stimulus were applied to both sides of the head (frontal cortex cl...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.21944

    authors: Navarro EA,Gomez-Perretta C,Montes F

    更新日期:2016-01-01 00:00:00

  • Human keratinocytes in culture exhibit no response when exposed to short duration, low amplitude, high frequency (900 MHz) electromagnetic fields in a reverberation chamber.

    abstract::We exposed normal human epidermal keratinocytes to short duration, high frequency, and low amplitude electromagnetic fields, similar to that used by mobile phone technologies. We paid particular attention to the control of the characteristics of the electromagnetic environment generated within a mode stirred reverbera...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20641

    authors: Roux D,Girard S,Paladian F,Bonnet P,Lalléchère S,Gendraud M,Davies E,Vian A

    更新日期:2011-05-01 00:00:00

  • Wire codes, magnetic fields, and childhood cancer.

    abstract::Childhood cancer has been modestly associated with wire codes, an exposure surrogate for power frequency magnetic fields, but less consistently with measured fields. We analyzed data on the population distribution of wire codes and their relationship with several measured magnetic field metrics. In a given geographic ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1521-186x(1997)18:2<99::aid-bem2>3.0

    authors: Kheifets LI,Kavet R,Sussman SS

    更新日期:1997-01-01 00:00:00