[Pneumococcal pneumonia in the era of heptavalent pneumococcal conjugate vaccine].


INTRODUCTION:To describe clinical features, complications, serotypes and antibiotic resistance in pneumococcal pneumonia in our environment after the generalization of the heptavalent conjugate vaccine (PCV-7) in paediatrics. MATERIAL AND METHODS:Prospective study of episodes of pneumococcal pneumonia, with positive cultures in patients treated in the emergency department from January 2006 to February 2010. RESULTS:We studied 346 episodes in 320 patients, 335 belonged to 309 adult patients, 221 (71.5%) males, median age 68 years (range 16-94), and 11 episodes to patients<15 years. Two-hundred and thirty seven (68.5%) episodes were community acquired. Bacteraemia was present in 130 (37.6%) cases, with a tendency towards an increased risk in patients < 65 years (OR=1.56, 95% CI 0.96- 2.56, P=.07). Thirteen (3.8%) patients developed empyema and 33 (9.5%) septic shock. The mean age of patients with empyema was lower (P=.03). In the multivariate analysis were related to the presence of bacteraemia: a history of chronic respiratory disease (OR=0.45, 95% CI 0.25-0.81, P=.008), positive urinary antigen (OR 2.02, 95% CI 1 13-3.62, P=.01) and pleural effusion (OR=3.86, 95% CI 1.79-8.35, P=.001). Shock was associated with Fine IV-V stage (OR=23.6, 95% CI 4.96-112.82, P<.001), age < 65 years (OR=4.47, 95% CI 1.75-11.39, P=.002) and pleural effusion (OR=4.15, 95% CI 1.65 to 10.41, P=.002). Increased mortality risk was associated with presence of any complication (OR=6.6, 95% CI 1.5-27.2, P=.009) and specifically septic shock (OR=3.3, 95% CI 1.06-10.3, P=.04). Most serotypes obtained were not included in the VNC-7. CONCLUSIONS:Pneumococcal pneumonia after generalisation of PCV-7 is mainly related to non-vaccine serotypes. Younger patients without respiratory disease are at increased risk of bacteraemia, empyema, and septic shock, the latter being associated with a higher mortality.


Payeras A,Villoslada A,Garau M,Borras M,Pareja A,Beingolea D,García-Gasalla M,Gallegos Mdel C,Alonso-Villaverde CJ




Has Abstract


2011-04-01 00:00:00














  • In vitro activity of echinocandins against non-Candida albicans: is echinocandin antifungal activity the same?

    abstract::The echinocandins anidulafungin, caspofungin, and micafungin have a broad and similar spectrum of in vitro and in vivo activity against most Candida spp. Minimal inhibitory concentrations (MICs) for Candida spp. are usually below 1 μg/mL for most isolates. The exceptions are Candidaparapsilosis and C. guilliermondii. ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Espinel-Ingroff A,Cantón E

    更新日期:2011-03-01 00:00:00

  • [Comparative study of three culture media for detecting group B Streptococcus colonization in pregnant women].

    abstract:OBJECTIVE:To compare the efficacy of three culture media to detect vaginal and rectal colonization by group B streptococci (GBS) in pregnant women. METHODS:We processed 1334 samples from 861 pregnant women: in 388 patients only vaginal swab was cultured (Group A) and in 473 vaginal and rectal swabs were cultured (Grou...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Bosch-Mestres J,Martín-Fernández RM,Jiménez de Anta-Losada MT

    更新日期:2003-08-01 00:00:00

  • [Epidemiologic and therapeutic aspects of bacteremic infections of the urinary tract].

    abstract::A survey was carried out of all urinary tract infections which developed bacteremia during an 18 month period. The number of episodes of bacteremia of urinary origin (BUO) detected in our institution during that period was 108. The urinary tract was the most common origin of the cases of community acquired (CA) bacter...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Tomás S,Torné J,Soriano JC,García-Flores A,Garcés JM,Drobnic L,Morta M,Torres JM

    更新日期:1989-02-01 00:00:00

  • [Outbreak of gastroenteritis in a nursery school caused by a strain of Salmonella enterica serovar Typhimurium carrying the hybrid virulence-resistance plasmid pUO-StVR2].

    abstract:OBJECTIVE:Epidemiological and microbiological study of a salmonellosis outbreak, affecting 22 children in a nursery school in Oviedo (Spain). METHODS:Attack rates and epidemic curves were determined, and bacterial typing methods were applied. RESULTS:The outbreak was attributed to a Salmonella enterica serovar Typhim...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Bances M,Herrero A,González Y,Rodicio MR,González-Hevia MA

    更新日期:2007-06-01 00:00:00

  • [Clinical and etiological features of community-acquired pneumonia in the elderly].

    abstract:BACKGROUND:The aim of the present study was to know the clinical and etiologic features of community-acquired pneumonia (CAP) in elderly patients requiring hospital admission. METHODS:A prospective study of 36 consecutive patients aged over 70 years, admitted to a general hospital was performed. Standard analytical de...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Llorente JL,Zalacaín R,Gaztelurrutia L,Talayero N,Pérez M,Badiola C,Sobradillo V

    更新日期:1994-01-01 00:00:00

  • [Infection in heart transplantation].

    abstract::Heart transplantation has emerged as the therapy of choice for selected patients with life-threatening, irremediable heart disease. Infectious complications are frequent, but are no longer the leading cause of death. Late infections (particularly viral infections), however, are still a threat to long-term graft surviv...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Gurguí M,Muñoz P

    更新日期:2007-11-01 00:00:00

  • Surveillance of surgical site infections in elective colorectal surgery. Results of the VINCat Program (2007-2010).

    abstract::The VINCat Program is a standardized surveillance program of healthcare infections in Catalonia, Spain. This program includes monitoring of surgical site infections (SSI) of elective colorectal surgery. The aim of this study was to define SSI rates in colorectal surgery among VINCat hospitals over a period of 4 years....

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Pujol M,Limón E,López-Contreras J,Sallés M,Bella F,Gudiol F,VINCat Program.

    更新日期:2012-06-01 00:00:00

  • First national survey of the diagnosis of Helicobacter pylori infection in Clinical Microbiology Laboratories in Spain.

    abstract:INTRODUCTION:The aim of this study was to know, through a national survey, the methods and techniques used for the diagnosis of Helicobacter pylori (Hp) in the different Clinical Microbiology Services/Laboratories in Spain, as well as antibiotic resistance data. METHODS:The survey requested information about the diagn...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Miqueleiz-Zapatero A,Alba-Rubio C,Domingo-García D,Cantón R,Gómez-García de la Pedrosa E,Aznar-Cano E,Leiva J,Montes M,Sánchez-Romero I,Rodríguez-Díaz JC,Alarcón-Cavero T,Grupo de Trabajo de Diagnóstico Microbiológico de Helicobact

    更新日期:2020-11-01 00:00:00

  • [The prevalence of hepatitis A in the Guadalajara province. Is Spain a country with low endemia?].

    abstract:BACKGROUND:Spain, together with the other southern European countries, was considered to be an area with a moderate degree of endemia. This fact has consequences for tourists that visit these areas and for vaccination strategies. A prevalence study was proposed in order to get to know the situation of this infection in...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: González-Praetorius A,Rodríguez-Avial C,Fernández C,Teresa Pérez-Pomata Mf M,Gimeno C,Bisquert J

    更新日期:2001-11-01 00:00:00

  • [Colonic tuberculosis as a cause of rectal bleeding in 2 patients with HIV infection].

    abstract:BACKGROUND:Extrapulmonary tuberculosis is a relatively frequent disease in patients with HIV infection. This may be observed coinciding with pulmonary involvement or without diagnostic data of the same. Within extrapulmonary involvement, gastrointestinal involvement is one of the least frequently observed and its diagn...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Pintor E,Piret MV,Velasco M,Barreiro P,Ruiz M,Blanco J

    更新日期:1996-11-01 00:00:00

  • [Mycobacterium fortuitum in patients with chronic renal insufficiency: apropos of 2 cases].

    abstract::Mycobacterium fortuitum is a rapidly growing mycobacteria recovered from human infections such as skin, soft tissue, skeletal and pulmonary infectious diseases. We report 2 cases of M. fortuitum isolation from clinical samples from two patients placed on dialysis program. Our clinical findings were: The first, the pre...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Viguera J,Oliva JA,Pascual R,Lens XM,Carrió J,Mallafré JM

    更新日期:1990-05-01 00:00:00

  • [Clinical and epidemiological characteristics of human immunodeficiency virus infection in foreigners residing in Elche, Spain (1998-2003)].

    abstract:BACKGROUND:To determine the characteristics of HIV-infection in foreign patients residing in Elche, Spain. METHOD:A retrospective comparative analysis of clinical and epidemiological characteristics was performed to study HIV-infection in foreign immigrants, foreigners who were not immigrants and the native Spanish po...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Ramos JM,Gutiérrez F,Padilla S,Masiá M,Escolano C

    更新日期:2005-10-01 00:00:00

  • [Empirical treatment of febrile episodes in patients with neutropenia in bone marrow transplantation].

    abstract::The results of therapy of febrile episodes during the pregraft phase in bone marrow transplant was retrospectively evaluated in 84 granulocytopenic patients. Most patients received co-trimoxazole and i.v. ticarcillin as antibacterial prophylaxis. 47 episodes were treated with a third generation cephalosporin plus an a...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Pérez M,Muruzábal MJ,Gómez Casares MT,Alsar MJ,Conde E,Iriondo A,Garijo J,Richard C,Baro J,Aguado JM

    更新日期:1990-10-01 00:00:00

  • [Induction of interleukin-6 by Borrelia burgdorferi in different cell cultures].

    abstract:BACKGROUND:To determine variability, if exists, in interleukin-6 (IL-6) response by different cell cultures stimulated by Borrelia burgdorferi. METHODS:Five human embryonic diploid fibroblast cell lines (three of them of lung origin) and four human synovial cell cultures were used. Induction of IL-6 was made with B. b...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Ponte C,Gadea I,Vallejo JC,Soriano F

    更新日期:1997-02-01 00:00:00

  • Can MALDI-TOF mass spectrometry be used with intravascular catheters?

    abstract:INTRODUCTION:The use of the matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry has shown to be effective and fast in some clinical specimens for the identification of colonizing microorganisms. The objective of the study was to analyze the validity values for the prediction of colo...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Guembe M,Rodríguez-Sánchez B,Ruiz A,Martín-Rabadán P,Rodríguez-Créixems M,Bouza E

    更新日期:2014-06-01 00:00:00

  • [Dental implant-related infections].

    abstract::Dental implant-associated infections are expected to be increasingly more common as the number of patients with implants for more than 10 years rises. There are 2 stages of peri-implant infection: early mucositis, consisting of inflammation of the peri-implant soft tissues without loss of supporting bone, and a more a...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: López-Cerero L

    更新日期:2008-11-01 00:00:00

  • [Food poisoning outbreak due to the consumption of spaghetti a la carbonara caused by Salmonella enteritidis].

    abstract:INTRODUCTION:This paper reports a clinico-epidemiological and microbiological investigation conducted into an outbreak of gastrointestinal infection due to Salmonella enteritidis, where the most likely food vehicle was spaghetti a la carbonara. METHODS:An historic cohort study was conducted out among persons exposed t...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Godoy P,Artigues A,Usera MA,González JL,Pablo N,Agustí M

    更新日期:2000-06-01 00:00:00

  • [Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Spanish hospitals: 2nd multicenter study (GEIH-BLEE project, 2006)].

    abstract:INTRODUCTION:During the year 2000, the 1st nationwide project (GEIH-BLEE Project 2000) on Escherichia coli and Klebsiella pneumoniae producing extended-spectrum ss-lactamases (ESBL) was carried out in Spain. The 2nd nationwide study was developed in 2006 to investigate the evolution of this problem. METHODS:A prospect...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,多中心研究


    authors: Angel Díaz M,Ramón Hernández J,Martínez-Martínez L,Rodríguez-Baño J,Pascual A,Grupo de Estudio de Infección Hospitalaria (GEIH).

    更新日期:2009-11-01 00:00:00

  • [Campylobacter jejuni and HIV infection].

    abstract:OBJECTIVE:To evaluate the characteristics of the Campylobacter jejuni infection in HIV positive patients. DESIGN:We report all cases appeared in our hospital between September 1991 and October 1992 with: HIV infection, chronic diarrhoea and C. jejuni in stool culture. Epidemiologic factors, other opportunist infection...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Martínez RM,Figueras MP,Ramos C,Sanjuán F,Aguirre JM

    更新日期:1994-02-01 00:00:00

  • Update on bacteraemia in oncology and hematology.

    abstract::The present article is an update of the literature on bacteraemia in onco-hematologic patients. A multidisciplinary group of Spanish physicians with an interest in this field selected the most important papers published recently. Papers from the fields of basic science, epidemiology, causative microorganisms and clini...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Fortún J,Sanz MÁ,Madero L,López J,de la Torre J,Jarque I,Vallejo C

    更新日期:2011-03-01 00:00:00

  • [Global HIV epidemiology and current migration].

    abstract::One of the current characteristics of migration is its tendency to concentrate in industrialized countries, as well as its feminization and diversity. From a healthcare point of view, the phenomenon of migration has aroused interest in the possible transfer of transmissible infectious diseases from some regions to oth...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Gascón Brustenga J,Navarro Beltrá M,Muñoz Sanz A,Mahillo Durán B

    更新日期:2008-05-01 00:00:00

  • [Pharmacology, pharmacokinetic features and interactions of atazanavir].

    abstract::Atazanavir (ATV) is an HIV protease inhibitor (IP) with a high in vitro activity against HIV-1, that demonstrates a high additive activity in the presence of other antiretrovirals and a synergic activity with other PI. Oral absorption is greater than 68%, maximum concentration (C(max)) being reached approximately 2 to...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: López-Cortés LF

    更新日期:2008-12-01 00:00:00

  • [Evaluation of a new method (Filtrachek-UTI) for the detection of bacteriuria].

    abstract::The diagnostic effectiveness of a new test for the detection of bacteriuria (Filtrachek-UTI) was compared with Gram stain and semiquantitative culture in 955 urine samples. 276 of these were from inpatients (108 males and 168 females), and 677 from outpatients (206 males and 471 females). Overall 229 positive cultures...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Conejo MC,Pérez MJ,Palomares JC

    更新日期:1989-08-01 00:00:00

  • [Comparison of conventional and non-conventional serological tests for the diagnosis of imported Chagas disease in Spain].

    abstract:INTRODUCTION:Trypanosoma cruzi infection is a major imported parasitic disease in Spain, because of the increase of immigrants from endemic areas. Since the laboratory diagnosis during the chronic phase is based on detection of anti-T. cruzi IgG antibodies, our aims were to compare 10 tests for determining anti-T. cruz...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Flores-Chávez M,Cruz I,Rodríguez M,Nieto J,Franco E,Gárate T,Cañavate C

    更新日期:2010-05-01 00:00:00

  • [Epidemiology of infections in neutropenic patients].

    abstract::Epidemiological data are useful to determine changes in forms of clinical expression and in the microbial agents causing infections. This allows empirical or preemptive treatments to be designed and can guide diagnostic tests. Empirical data also allow patients to be classified by risk group in order to decide on the ...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Díaz-Mediavilla J,Lizasoain M

    更新日期:2005-12-01 00:00:00

  • Fosamprenavir (GW433908)/ritonavir in HIV-infected patients: efficacy and safety results from the Spanish Expanded Access Program.

    abstract:INTRODUCTION:The use of protease inhibitors (PI) has led to a decrease in HIV-1-related mortality and morbidity. The objective of this study was to collect safety data on treatment with fosamprenavir/ritonavir (FPV/r) 700/100mg BID in HIV-infected patients through an expanded access program. PATIENTS AND METHODS:Prosp...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Pérez-Elias MJ,Sánchez-Conde M,Soriano V,Mallolas J,Luque I,Rodríguez-Alcántara F,Fosamprenavir Expanded Access Program Group.

    更新日期:2009-01-01 00:00:00

  • [Microbiology of transplants].

    abstract::Infections are one of the main complications that decisively affect the final outcome of transplants. Clinical microbiology laboratory has a key role in diagnosis, treatment and prevention of these complications. Centres with transplant programs must be technically supported with a well developed laboratory with speci...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Pérez JL,Ayats J,Fortún J,de Oña M,Pumarola T

    更新日期:2011-11-01 00:00:00

  • Factors related to quality of life of people living with HIV in Alicante, Spain.

    abstract:PURPOSE:To analyze the determinants that influence the health-related quality of life of people living with HIV in Alicante (Spain). METHODS:A cross-sectional study was conducted, which recruited 214 Spanish-speaking participants over 18 years of age living with HIV from an outpatient consulting office of the infectio...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: García-López YL,Bernal-Soriano MC,Torrús-Tendero D,Delgado de Los Reyes JA,Castejón-Bolea R

    更新日期:2020-05-19 00:00:00

  • [Update on hepatitis C therapy. New drugs, treatment response monitoring and emergence of resistance].

    abstract::The development of novel direct antiviral agents (DAAs) against hepatitis C virus (HCV) has represented a breakthrough in the treatment of chronic hepatitis C. Telaprevir and boceprevir are the first two protease inhibitor (PI) DAAs to be approved for combination therapy with pegylated interferon (PEG-IFN) and ribavir...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


    authors: Chueca Porcuna N,Alvarez Estévez M,Parra Ruiz J,Hernández Quero J,García García F

    更新日期:2013-02-01 00:00:00

  • Strategies for the cure of HIV infection.

    abstract::The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of H...

    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


    authors: Rodríguez-Muñoz J,Moreno S

    更新日期:2019-04-01 00:00:00