Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-L-alanine) during the neonatal period.

Abstract:

:We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) during the neonatal period causes cognitive impairments in adult rats. The aim of this study was to investigate the long-term effects of neonatal BMAA exposure on learning and memory mechanisms and to identify early morphological changes in the neonatal brain. BMAA was injected subcutaneously in rat pups on postnatal days 9-10. BMAA (50 and 200 mg/kg) caused distinct deficits in spatial learning and memory in adult animals but no morphological changes. No impairment of recognition memory was detected, suggesting that neonatal exposure to BMAA preferentially affects neuronal systems that are important for spatial tasks. Histopathological examination revealed early neuronal cell death as determined by TUNEL staining in the hippocampus 24 h after a high dose (600 mg/kg) of BMAA whereas no changes were observed at lower doses (50 and 200 mg/kg). In addition, there was a low degree of neuronal cell death in the retrosplenial and cingulate cortices, areas that are also important for cognitive function. Taken together, these results indicate that BMAA is a developmental neurotoxin inducing long-term changes in cognitive function. The risk posed by BMAA as a potential human neurotoxin merits further consideration, particularly if the proposed biomagnifications in the food chain are confirmed.

journal_name

Behav Brain Res

authors

Karlsson O,Roman E,Berg AL,Brittebo EB

doi

10.1016/j.bbr.2011.01.056

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

310-20

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(11)00097-0

journal_volume

219

pub_type

杂志文章
  • D1- and D2-like dopamine receptors in the CA1 region of the hippocampus are involved in the acquisition and reinstatement of morphine-induced conditioned place preference.

    abstract::The hippocampus plays a vital role in processing contextual memories and reward related learning tasks, such as conditioned place preference (CPP). Among the neurotransmitters in the hippocampus, dopamine is deeply involved in reward-related processes. This study assessed the role of D1- and D2-like dopamine receptors...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.06.061

    authors: Assar N,Mahmoudi D,Farhoudian A,Farhadi MH,Fatahi Z,Haghparast A

    更新日期:2016-10-01 00:00:00

  • Long-term effects on motor activity induced by apomorphine or scopolamine after intracerebral injections of cycloheximide or glutamate shortly after hatching in chickens.

    abstract::Compared to controls, bilateral forebrain injections of cycloheximide or glutamate in 2-day-old chicks resulted in significantly less activity in response to intraperitoneal injections of the dopaminergic agonist, apomorphine, or the cholinergic antagonist, scopolamine, when tested on stabilimeters four weeks later. T...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(82)90038-9

    authors: Sanberg PR,Mark RF

    更新日期:1982-07-01 00:00:00

  • Monitoring dopamine transmission in the rat nucleus accumbens shell and core during acquisition of nose-poking for sucrose.

    abstract::On the basis of between subjects monitoring of in vivo dopamine (DA) transmission in the rat nucleus accumbens (NAc) shell and core during response-contingent and non-contingent sucrose feeding we have hypothesized that long term, daily exposure to sucrose feeding results in the acquisition of conditioned/discriminati...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.03.056

    authors: Bassareo V,Cucca F,Frau R,Di Chiara G

    更新日期:2015-01-01 00:00:00

  • The paracrine effect of cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat.

    abstract::Hypoxia-ischemia (HI)-induced perinatal encephalopathy frequently causes chronic neurological morbidities and acute mortality. Bone mesenchymal stem cell (BMSC) transplantation could potentially promote functional and anatomical recovery of ischemic tissue. In vitro hypoxic preconditioning is an effective strategy to ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.05.055

    authors: Dai Y,Li W,Zhong M,Chen J,Cheng Q,Liu Y,Li T

    更新日期:2017-08-14 00:00:00

  • Intranigral stimulation of oral movements by [Pro9] substance P, a neurokinin-1 receptor agonist, is enhanced in chronically neuroleptic-treated rats.

    abstract::Bilateral intranigral infusions of three different peptide agonists were made in rats exposed to fluphenazine decanoate, 30 mg/kg/month (FLU) or vehicle (CON) for seven months. Oral movements were monitored repeatedly during the neuroleptic pretreatment period, as well as before the intranigral infusion and during a 9...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90064-w

    authors: Liminga U,Gunne LM

    更新日期:1993-10-21 00:00:00

  • Age-related disorders of sleep and motor control in the rat models of functionally distinct cholinergic neuropathology.

    abstract::We studied the impact of aging during sleep in the rat models of Alzheimer's (AD) and Parkinson's (PD) disease cholinergic neuropathology to determine the possible different and earlier onset of age-related sleep disorder during the neurodegenerative diseases vs. healthy aging. We used the bilateral nucleus basalis (N...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.12.046

    authors: Ciric J,Lazic K,Petrovic J,Kalauzi A,Saponjic J

    更新日期:2016-03-15 00:00:00

  • Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) mice.

    abstract::The role of histamine in brain function has been studied using histidine decarboxylase (HDC) deficient male mice. As the effects of HDC deficiency on brain function might be sex-dependent, we behaviorally analyzed Hdc(-/-) and control female mice. Compared to female control mice, Hdc(-/-) female mice showed hypoactivi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.10.016

    authors: Acevedo SF,Pfankuch T,Ohtsu H,Raber J

    更新日期:2006-03-15 00:00:00

  • Prenatal stress induced gender-specific alterations of N-methyl-d-aspartate receptor subunit expression and response to Aβ in offspring hippocampal cells.

    abstract::Prenatal stress (PS) is one of adverse life events during pregnancy, which may increase vulnerability to cognitive impairment in adult offspring. Aβ synaptotoxicity is one important pathological factor for cognitive impairment, and PS-induced cognitive disorder is closely associated with N-Methyl-d-Aspartate receptor ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.08.036

    authors: Fang Y,Li H,Chang L,Song Y,Ma L,Lu L,Du Z,Li Y,Liu J,Wu Y

    更新日期:2018-01-15 00:00:00

  • Systemic administration of anti-NGF antibodies to neonatal mice impairs 24-h retention of an inhibitory avoidance task while increasing ChAT immunoreactivity in the medial septum.

    abstract::Neonatal mice received subcutaneous injections of either antibody against murine NGF raised in goat (3 mg, injection volume 50 microliters) or preimmune serum on postnatal days 2, 4, 6, 8, 10, and 12. They were tested on postnatal days 15-16 or 20-21 for learning and 24-h retention of a passive avoidance step-through ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(95)00234-0

    authors: Calamandrei G,Ricceri L,Valanzano A

    更新日期:1996-08-01 00:00:00

  • Offspring-exposure reduces depressive-like behaviour in the parturient female rat.

    abstract::In women, breastfeeding generally results in reductions in anxiety and increased positive mood. However, approximately 10-15% of women experience depressed mood and increased anxiety during the first year postpartum. Recent research has demonstrated that offspring-exposure is important for the reduction in behaviours ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.08.001

    authors: Pawluski JL,Lieblich SE,Galea LA

    更新日期:2009-01-30 00:00:00

  • Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?

    abstract::Stress during pregnancy is associated with lifetime negative consequences for the offspring. The present study examined the effects of prenatal stress on symptoms of illness following an immune challenge in mice. Additionally, this study examined whether pretreatment with fluoxetine (FLX) could prevent the effects of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.09.021

    authors: Avitsur R

    更新日期:2017-01-15 00:00:00

  • Acute nicotine delays extinction of contextual fear in mice.

    abstract::Smoking is linked to post-traumatic stress disorder (PTSD) which suggests smoking is either a risk factor or an attempt at self-medication. The ability to reduce or extinguish fear-related memories may be altered in patients with PTSD and it is possible that nicotine modulates this. Although there are numerous studies...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.01.031

    authors: Kutlu MG,Gould TJ

    更新日期:2014-04-15 00:00:00

  • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

    abstract::Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.05.008

    authors: Bour A,Grootendorst J,Vogel E,Kelche C,Dodart JC,Bales K,Moreau PH,Sullivan PM,Mathis C

    更新日期:2008-11-21 00:00:00

  • Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat.

    abstract::Male rats outperform females in spatial tasks, such as the water maze (WM). Female rats are known to have higher basal serum corticosterone (CORT) levels and to manifest a more rapid and stronger CORT response to novel stressors. Sex differences in stress responses to the handling and forced swimming in the WM task mi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2003.08.019

    authors: Beiko J,Lander R,Hampson E,Boon F,Cain DP

    更新日期:2004-05-05 00:00:00

  • Visual mismatch response and fMRI signal adaptation correlate in the occipital-temporal cortex.

    abstract::Several electrophysiological studies found response differences to a given stimulus when it is repeated frequently as compared to when it occurs rarely in oddball sequences. Initially defined in acoustic perception, such difference also exists in the visual modality and is referred to as visual mismatch negativity (vM...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.03.001

    authors: Amado C,Stoyanova P,Kovács G

    更新日期:2018-07-16 00:00:00

  • Chronic ethanol consumption induces tolerance to the spatial memory impairing effects of acute ethanol administration in rats.

    abstract::A large number of studies in rats have investigated the effects of acute and chronic ethanol administration on performance on many spatial learning and memory tasks. However, no study has addressed the problem of whether chronic ethanol consumption induces tolerance to acute ethanol-induced spatial memory deficits. In...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(02)00134-1

    authors: Boulouard M,Lelong V,Daoust M,Naassila M

    更新日期:2002-10-17 00:00:00

  • Parcellation of parietal cortex: convergence between lesion-symptom mapping and mapping of the intact functioning brain.

    abstract::Spatial-attentional deficits are highly prevalent following stroke. They can be clinically detected by means of conventional bedside tests such as target cancellation, line bisection and the visual extinction test. Until recently, lesion mapping studies and functional imaging of the intact brain did not agree very wel...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2008.12.005

    authors: Vandenberghe R,Gillebert CR

    更新日期:2009-05-16 00:00:00

  • Increase of spike-LFP coordination in rat prefrontal cortex during working memory.

    abstract::Working memory (WM) refers to the short-term maintenance of information with higher cognitive functions. Recent researches show that local field potentials (LFPs) and spikes, as different modes of neural signals, encode WM, respectively. There is a growing interest in how these two signals encode WM in coordination. T...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.12.030

    authors: Li S,Ouyang M,Liu T,Bai W,Yi H,Tian X

    更新日期:2014-03-15 00:00:00

  • Hippocampal BDNF treatment facilitates consolidation of spatial memory in spontaneous place recognition in rats.

    abstract::In order to investigate the role of brain-derived neurotrophic factor (BDNF) in the consolidation of spatial memory, we examined the relationship between the increase of hippocampal BDNF and the establishment of long-term spatial memory in spontaneous place recognition test in rats. The test consisted of a sample phas...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.01.034

    authors: Ozawa T,Yamada K,Ichitani Y

    更新日期:2014-04-15 00:00:00

  • Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task.

    abstract::Alcohol abuse is a major medical problem. Zebrafish have been proposed to model alcohol related human disorders. Alcohol impairs learning and memory. Here, we analyze the effects of alcohol on performance of zebrafish in a recently developed latent learning paradigm. We employ a 2×3×2 experimental design (chronic×acut...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.12.013

    authors: Luchiari AC,Salajan DC,Gerlai R

    更新日期:2015-04-01 00:00:00

  • Baclofen enhances extinction of opiate conditioned place preference.

    abstract::Conditioned opiate reward (COR) is rapidly acquired and slowly extinguished. The slow rate of extinction of the salience of drug-related cues contributes to drug craving and relapse. The gamma-aminobutyric acid receptor type B (GABA(B)) agonist, baclofen, attenuates the unconditioned rewarding actions of several drugs...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.10.013

    authors: Heinrichs SC,Leite-Morris KA,Carey RJ,Kaplan GB

    更新日期:2010-03-05 00:00:00

  • Differential effects of oxycodone, hydrocodone, and morphine on the responses of D2/D3 dopamine receptors.

    abstract::Oxycodone and hydrocodone are opioids which are widely used for pain management and are also commonly misused and abused. The exposure to opioid analgesics has been associated with altered responses of D2-like dopamine receptors (D2DRs). Our recent results suggest that various opioids will differentially modulate the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.01.023

    authors: Emery MA,Bates ML,Wellman PJ,Eitan S

    更新日期:2015-05-01 00:00:00

  • Peptide-induced emesis in dogs.

    abstract::Systemic administration of apomorphine, angiotensin II, neurotensin and leucine-enkephalin induces emesis in dogs in a dose-dependent fashion. Receptors for Leu-enkephalin and angiotensin II but not apomorphine show receptor desensitization, such that a second systemic administration 5 min after the first is ineffecti...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90220-1

    authors: Carpenter DO,Briggs DB,Strominger N

    更新日期:1984-03-01 00:00:00

  • Development of early motor learning and topical motor skills in a model of cerebellar degeneration.

    abstract::The development of motor learning and topical motor skills has been studied during the first month of life in neurodeficient Lurcher mutant mice derived from C3H strain. The examination of motor functions was conducted using four methods when animals were consecutively placed on: a horizontal wire, a rotating cylinder...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/S0166-4328(03)00247-X

    authors: Krízková A,Vozeh F

    更新日期:2004-04-02 00:00:00

  • Domains of rehabilitation: a theoretical perspective.

    abstract::On the basis of a taxonomy of functions an outline is given on potential deficits after brain lesions. The taxonomy distinguishes between "what"- and "how"-functions. Whereas for what-functions the localizing principle may apply, the how-functions being responsible for the logistics of the brain are non-locally repres...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0166-4328(93)90017-k

    authors: von Steinbüchel N,Pöppel E

    更新日期:1993-07-30 00:00:00

  • Serotonin: from sensory processing to schizophrenia using an electrophysiological method.

    abstract::Serotonin plays a major role in sensory processing especially with in the primary auditory cortex. The so-called loudness dependence of auditory evoked potentials is generated by pyramidal cells of the primary auditory cortex (LDAEP) which are modulated by serotonergic projection fibers to the main regulators of pyram...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2014.05.042

    authors: Juckel G

    更新日期:2015-01-15 00:00:00

  • Immediate and long-term antidepressive-like effects of pre-pubertal escitalopram and omega-3 supplementation combination in young adult stress-sensitive rats.

    abstract::Major depressive disorder (MDD) affects a significant number of children and adolescents, yet treatment options for this population remain very limited. Escitalopram (ESC) is one of only two antidepressants approved as treatment for juvenile depression. Still, delayed onset of action, and immediate plus the risk of la...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.05.021

    authors: Steyn SF,Harvey BH,Brink CB

    更新日期:2018-10-01 00:00:00

  • NMDA receptor antagonists inhibit apomorphine-induced climbing behavior not only in intact mice but also in reserpine-treated mice.

    abstract::The present study showed that the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 {(+)-5-methyl-10,11-dihydroxy-5H-dibenzo-[a,d]-cyclohepten-5,10-im ine hydrogen maleate}, ketamine, dextrorphan and dextromethorphan attenuated apomorphine-induced climbing behavior in reserpine-treated mice. In a...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(98)00122-3

    authors: Kim HS,Rhee GS,Oh S,Park WK

    更新日期:1999-04-01 00:00:00

  • Mother rats bar-press for pups: effects of lesions of the mpoa and limbic sites on maternal behavior and operant responding for pup-reinforcement.

    abstract::This series of studies explored the operant response rates for pup-reinforcement of female Sprague Dawley rats that were either postpartum or cycling and sustained lesions of the medial preoptic area (mpoa), the lateral amygdala, the nucleus accumbens, or sham lesions. The last experiment tested the effects on operant...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(98)00109-0

    authors: Lee A,Clancy S,Fleming AS

    更新日期:1999-04-01 00:00:00

  • Intrahippocampal bethanechol in rats: behavioural, electroencephalographic and neuropathological correlates.

    abstract::Unilateral microinjections of bethanechol chloride into the CA3 subfield of the dorsal hippocampus in unrestrained rats produced a seizure-related type behavioural and disseminated brain damage syndrome. Injection of bethanechol in the dose of 50 micrograms resulted in locomotor activation, mouth movements, teeth chat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(83)90026-8

    authors: Turski WA,Cavalheiro EA,Turski L,Kleinrok Z

    更新日期:1983-03-01 00:00:00