Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-L-alanine) during the neonatal period.

Abstract:

:We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) during the neonatal period causes cognitive impairments in adult rats. The aim of this study was to investigate the long-term effects of neonatal BMAA exposure on learning and memory mechanisms and to identify early morphological changes in the neonatal brain. BMAA was injected subcutaneously in rat pups on postnatal days 9-10. BMAA (50 and 200 mg/kg) caused distinct deficits in spatial learning and memory in adult animals but no morphological changes. No impairment of recognition memory was detected, suggesting that neonatal exposure to BMAA preferentially affects neuronal systems that are important for spatial tasks. Histopathological examination revealed early neuronal cell death as determined by TUNEL staining in the hippocampus 24 h after a high dose (600 mg/kg) of BMAA whereas no changes were observed at lower doses (50 and 200 mg/kg). In addition, there was a low degree of neuronal cell death in the retrosplenial and cingulate cortices, areas that are also important for cognitive function. Taken together, these results indicate that BMAA is a developmental neurotoxin inducing long-term changes in cognitive function. The risk posed by BMAA as a potential human neurotoxin merits further consideration, particularly if the proposed biomagnifications in the food chain are confirmed.

journal_name

Behav Brain Res

authors

Karlsson O,Roman E,Berg AL,Brittebo EB

doi

10.1016/j.bbr.2011.01.056

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

310-20

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(11)00097-0

journal_volume

219

pub_type

杂志文章
  • Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats.

    abstract::The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasega...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00029-7

    authors: Kitaichi K,Noda Y,Miyamoto Y,Numaguchi A,Osawa H,Hasegawa T,Furukawa H,Nabeshima T

    更新日期:1999-08-01 00:00:00

  • Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults.

    abstract::Genetic variations of COMT and KIBRA, which were reported to be expressed in the hippocampus, have been linked to memory function. However, their interaction on the hippocampal structure remains unknown. This study aimed to explore the interaction effects of COMT rs4680 and KIBRA rs17070145 on the hippocampal subfield...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112550

    authors: Wang J,Wu S,Sun Y,Fang Y,Wu R,Lu J,Qing Z,Liang X,Wang Z,Zhang W,Chen Q,Cao P,Zhang B

    更新日期:2020-04-20 00:00:00

  • Chronic administration of quercetin prevent spatial learning and memory deficits provoked by chronic stress in rats.

    abstract::There are several reports that cognitive impairment is observed in stress related disorders and chronic stress impairs learning and memory. However, very few studies have looked into the possible ways of preventing this stress-induced deficit. This research study was conducted to evaluate the effects of quercetin, a n...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.05.015

    authors: Mohammadi HS,Goudarzi I,Lashkarbolouki T,Abrari K,Elahdadi Salmani M

    更新日期:2014-08-15 00:00:00

  • Homing behavior of hippocampus and parahippocampus lesioned pigeons following short-distance releases.

    abstract::The avian hippocampal formation has been proposed to play a critical role in the neural regulation of a navigational system used by homing pigeons to locate their loft once in the familiar area near home. In support of this hypothesis, the homing performance of pigeons with target lesions of either the hippocampus or ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90079-t

    authors: Bingman VP,Mench JA

    更新日期:1990-11-30 00:00:00

  • Scopolamine increases perseveration in mice subjected to the detour test.

    abstract::Increased perseveration is associated with aging and leads to an impaired ability to cope with problems. Aging is also associated with progressing dysfunction of the cholinergic system which is involved in the regulation of various cognitive processes. Therefore, we tested an effect of an anticholinergic drug on the l...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.07.028

    authors: Juszczak GR,Stryjek R

    更新日期:2019-01-01 00:00:00

  • Daily infusion of melatonin entrains circadian activity rhythms in the diurnal rodent Arvicanthis ansorgei.

    abstract::The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00411-9

    authors: Slotten HA,Krekling S,Sicard B,Pévet P

    更新日期:2002-06-15 00:00:00

  • Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer.

    abstract::The negative impact of chemotherapy on cognitive function in cancer patients has gained increasing attention in the last decade. Whilst the short-term acute effects on cognition are expected following chemotherapy, the persistence of such impairments in the long-term is still in question. This is despite clinical evid...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.07.043

    authors: Rendeiro C,Sheriff A,Bhattacharya TK,Gogola JV,Baxter JH,Chen H,Helferich WG,Roy EJ,Rhodes JS

    更新日期:2016-12-15 00:00:00

  • Dynamic adaptation of the blind pointing characteristic to stepwise lateral tilts of body, head, and trunk.

    abstract::Blind pointing (i.e. pointing to visual targets without seeing the pointing arm) was investigated in normal subjects in response to stepwise lateral tilts (20 degrees) of the body, head, and trunk. Blind pointing positions of the right index finger on the outer surface of a hemispherical screen were measured relative ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(88)90140-4

    authors: Ott D,Eckmiller R

    更新日期:1988-09-15 00:00:00

  • Vicarious ratings of social touch reflect the anatomical distribution & velocity tuning of C-tactile afferents: A hedonic homunculus?

    abstract::A subclass of C-fibres, C-tactile afferents (CTs), have been discovered which respond preferentially to low force/velocity stroking touch, that is typically perceived as pleasant. Molecular genetic visualization of these low-threshold mechanosensitive C-fibres (CLTMs) in mice revealed a denser distribution in dorsal t...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.11.046

    authors: Walker SC,Trotter PD,Woods A,McGlone F

    更新日期:2017-03-01 00:00:00

  • The problem of relating plasticity and skilled reaching after motor cortex stroke in the rat.

    abstract::The plasticity of the nervous system is illustrated in the many new neuronal connections that are formed during the acquisition of behavioral skills, loss of function after brain injury, and subsequent recovery of function. The present review describes the acquisition of skilled reaching, the act of reaching for food ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2007.12.026

    authors: Whishaw IQ,Alaverdashvili M,Kolb B

    更新日期:2008-09-01 00:00:00

  • Chronic corticosterone administration does not potentiate unconditioned freezing to the predator odor, trimethylthiazoline.

    abstract::Chronic high levels of corticosterone (CORT) are known to facilitate learning and memory of aversive events. Whether this effect of chronic CORT also generalizes to unconditioned or unlearned fear behavior is not known. The present study investigated whether high levels of chronic CORT enhance unconditioned fear to a ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.06.019

    authors: Rosen JB,Donley MP,Gray D,West EA,Morgan MA,Schulkin J

    更新日期:2008-12-01 00:00:00

  • NMDA receptor antagonism in the basolateral amygdala blocks enhancement of inhibitory avoidance learning in previously trained rats.

    abstract::Extensive evidence suggests that N-methyl-D-aspartate (NMDA) glutamate receptor channels in the amygdala are involved in fear-motivated learning, and infusion of NMDA receptor antagonists into the amygdala blocks memory of fear-motivated tasks. Recent studies have shown that previous training can prevent the amnestic ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00169-8

    authors: Roesler R,Vianna MR,de-Paris F,Rodrigues C,Sant'Anna MK,Quevedo J,Ferreira MB

    更新日期:2000-07-01 00:00:00

  • The effects of Ginkgo biloba extract on cognitive functions in aged female rats: the role of oxidative stress and brain-derived neurotrophic factor.

    abstract::The aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehic...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.10.032

    authors: Belviranlı M,Okudan N

    更新日期:2015-02-01 00:00:00

  • Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice.

    abstract::Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus la...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.12.028

    authors: Thackray SE,McAllister BB,Dyck RH

    更新日期:2017-03-15 00:00:00

  • Valence of physical stimuli, not housing conditions, affects behaviour and frontal cortical brain activity in sheep.

    abstract::Modulation of short-term emotions by long-term mood is little understood but relevant to understand the affective system and of importance in respect to animal welfare: a negative mood might taint experiences, whilst a positive mood might alleviate single negative events. To induce different mood states in sheep housi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.03.036

    authors: Vögeli S,Lutz J,Wolf M,Wechsler B,Gygax L

    更新日期:2014-07-01 00:00:00

  • Electrical intracerebral stimulation of the area postrema on taste aversion learning.

    abstract::The structural characteristics of the area postrema, its anatomical connections, participation in the detection of emesis-provoking substances and the effects of area postrema lesions on taste aversion learning acquisition, are all factors which speak in favor of a role as a chemoreceptor zone involved in the detectio...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(88)90172-6

    authors: Gallo M,Arnedo M,Agüero A,Puerto A

    更新日期:1988-10-01 00:00:00

  • Water maze performance of aged Sprague-Dawley rats in relation to retinal morphologic measures.

    abstract::The spatial learning ability of aged male and female Sprague-Dawley rats was assessed using the Morris water maze. To determine the influence of age-related visual deficits on performance levels, retinal morphologic measures were correlated with water maze performance for each rat. Rats were first trained on the water...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(94)00167-e

    authors: Spencer RL,O'Steen WK,McEwen BS

    更新日期:1995-06-01 00:00:00

  • Effects of an early postnatal hypoxia on the development of spontaneous head movements in rabbits.

    abstract::The early detection of minor brain dysfunctions resulting from perinatal hypoxia is very important since the prognosis of the affected children can be substantially improved by a prompt treatment. Therefore, this paper deals with the influence of an early postnatal hypoxia on the postnatal development of spontaneous h...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90148-j

    authors: Woldag H,Tegetmeyer H

    更新日期:1993-12-31 00:00:00

  • Intranigral stimulation of oral movements by [Pro9] substance P, a neurokinin-1 receptor agonist, is enhanced in chronically neuroleptic-treated rats.

    abstract::Bilateral intranigral infusions of three different peptide agonists were made in rats exposed to fluphenazine decanoate, 30 mg/kg/month (FLU) or vehicle (CON) for seven months. Oral movements were monitored repeatedly during the neuroleptic pretreatment period, as well as before the intranigral infusion and during a 9...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90064-w

    authors: Liminga U,Gunne LM

    更新日期:1993-10-21 00:00:00

  • Dopamine: mesocortical vs nigrostriatal uptake in isolated fighting mice and controls.

    abstract::Acute isolation-induced fighting in mice produced a striking 'dose-dependent' increase in Km and Vmax for DA uptake in mesocortical nerve endings (synaptosomes) but no significant changes for these uptake constants in nigrostriatal terminals. The selective response of the mesocortical system to fighting is similar to ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(83)90019-0

    authors: Hadfield MG

    更新日期:1983-03-01 00:00:00

  • Effect of MK 801 on priming of D1-dependent contralateral turning and its relationship to c-fos expression in the rat caudate-putamen.

    abstract::In rats with a unilateral 6-hydroxydopamine lesion of the ascending dopamine neurons, we investigated the relationship between the expression of Fos-like immunoreactivity in the caudate-putamen and contralateral turning behavior in response to dopamine agonists during the induction and expression of sensitization (pri...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(96)00002-2

    authors: Morelli M,Fenu S,Carta A,Di Chiara G

    更新日期:1996-09-01 00:00:00

  • D2 receptor density and prepulse inhibition in humans: negative findings from a molecular genetic approach.

    abstract::There is plenty of evidence from schizophrenia research and psychopharmacological experiments showing the influence of the dopaminergic neurotransmission on the prepulse inhibition (PPI). A lot of insights into the underlying neural mechanisms of the PPI have been gained from animal models, which are in need to be val...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.10.006

    authors: Montag C,Hartmann P,Merz M,Burk C,Reuter M

    更新日期:2008-03-05 00:00:00

  • Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation.

    abstract::Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and recipr...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.07.003

    authors: Hestermann D,Temel Y,Blokland A,Lim LW

    更新日期:2014-10-15 00:00:00

  • Spatial relational learning and memory abilities do not differ between men and women in a real-world, open-field environment.

    abstract::This study assesses gender differences in spatial and non-spatial relational learning and memory in adult humans behaving freely in a real-world, open-field environment. In Experiment 1, we tested the use of proximal landmarks as conditional cues allowing subjects to predict the location of rewards hidden in one of tw...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.09.046

    authors: Banta Lavenex P,Lavenex P

    更新日期:2010-02-11 00:00:00

  • Continuous place avoidance task reveals differences in spatial navigation in male and female rats.

    abstract::A new place navigation test was used to estimate the spatial orientation abilities of male and female rats. Animals had to avoid a room frame defined area on a rotating arena, entering of which was punished by mild footshock, i.e. rats had to avoid the same place in the room but different parts of the floor, which was...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00128-x

    authors: Cimadevilla JM,Fenton AA,Bures J

    更新日期:2000-01-01 00:00:00

  • The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat.

    abstract::Environmental enrichment (EE) involves enhancing an animal's environment, with the goal of improving animal welfare. Though a well-established discipline, the consequences of EE on behavioural pharmacological tests have not been extensively examined. The purpose of this study was to examine the consequences of EE (or ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.06.015

    authors: Simpson J,Kelly JP

    更新日期:2012-10-01 00:00:00

  • Enhancing the impact of visual extra-maze cues in a spatial orientation task.

    abstract::In a short-distance homing task, golden hamsters derive the homing direction both from visual extra-maze cues and from the integration of the outward journey. The relative importance of visual configurations in the control of homing was assessed by presenting these cues in conflict with path integration. The hamsters ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90175-e

    authors: Etienne AS,Joris S,Maurer R,Teroni E

    更新日期:1990-05-28 00:00:00

  • Modulating activity in the prefrontal cortex changes decision-making for risky gains and losses: a transcranial direct current stimulation study.

    abstract::When making choices under uncertainty, people usually consider both the risks and benefits of each option. Previous studies have found that weighing of risks and benefits during decision-making involves a complex neural network that includes the dorsolateral prefrontal cortex (DLPFC), but the causal effect of this net...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.02.037

    authors: Ye H,Chen S,Huang D,Wang S,Luo J

    更新日期:2015-06-01 00:00:00

  • Isoflurane in the presence or absence of surgery increases hippocampal cytokines associated with memory deficits and responses to brain injury in rats.

    abstract::Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2-4h of isoflurane anesthetic without surgical trauma can also impair cognitive function. We aimed ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.01.032

    authors: Callaway JK,Wood C,Jenkins TA,Royse AG,Royse CF

    更新日期:2016-04-15 00:00:00

  • Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice.

    abstract::Icariin is a major constituent of flavonoids isolated from Herba Epimedii. Several previous studies have demonstrated the antidepressant-like effects of icariin. After oral administration of icariin, 19 metabolites of icariin were detected in rat plasma. Icaritin is one such of metabolite of icariin. In this study, a ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.09.034

    authors: Wu X,Wu J,Xia S,Li B,Dong J

    更新日期:2013-11-01 00:00:00