Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-L-alanine) during the neonatal period.

Abstract:

:We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) during the neonatal period causes cognitive impairments in adult rats. The aim of this study was to investigate the long-term effects of neonatal BMAA exposure on learning and memory mechanisms and to identify early morphological changes in the neonatal brain. BMAA was injected subcutaneously in rat pups on postnatal days 9-10. BMAA (50 and 200 mg/kg) caused distinct deficits in spatial learning and memory in adult animals but no morphological changes. No impairment of recognition memory was detected, suggesting that neonatal exposure to BMAA preferentially affects neuronal systems that are important for spatial tasks. Histopathological examination revealed early neuronal cell death as determined by TUNEL staining in the hippocampus 24 h after a high dose (600 mg/kg) of BMAA whereas no changes were observed at lower doses (50 and 200 mg/kg). In addition, there was a low degree of neuronal cell death in the retrosplenial and cingulate cortices, areas that are also important for cognitive function. Taken together, these results indicate that BMAA is a developmental neurotoxin inducing long-term changes in cognitive function. The risk posed by BMAA as a potential human neurotoxin merits further consideration, particularly if the proposed biomagnifications in the food chain are confirmed.

journal_name

Behav Brain Res

authors

Karlsson O,Roman E,Berg AL,Brittebo EB

doi

10.1016/j.bbr.2011.01.056

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

310-20

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(11)00097-0

journal_volume

219

pub_type

杂志文章
  • Enhancement of latent inhibition in patients with chronic schizophrenia.

    abstract:OBJECTIVES:Latent inhibition (LI) refers to the retarding effects of inconsequential stimulus preexposure on subsequent conditioning to that stimulus, and reflects the organism's capacity to ignore irrelevant stimuli. LI is disrupted in schizophrenia patients, due to faster learning of the association between the condi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.08.023

    authors: Gal G,Barnea Y,Biran L,Mendlovic S,Gedi T,Halavy M,Feldon J,Fennig S,Levkovitz Y

    更新日期:2009-01-30 00:00:00

  • Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat.

    abstract::In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.11.021

    authors: Ciric J,Lazic K,Kapor S,Perovic M,Petrovic J,Pesic V,Kanazir S,Saponjic J

    更新日期:2018-02-26 00:00:00

  • Zebrafish (Danio rerio) responds differentially to stimulus fish: the effects of sympatric and allopatric predators and harmless fish.

    abstract::The zebrafish has been an excellent model organism of developmental biology and genetics. Studying its behavior will add to the already strong knowledge of its biology and will strengthen the use of this species in behavior genetics and neuroscience. Anxiety is one of the most problematic human psychiatric conditions....

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.07.037

    authors: Bass SL,Gerlai R

    更新日期:2008-01-10 00:00:00

  • Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury.

    abstract::Neurological disorders are a major cause of chronic disability globally among which stroke is a leading cause of chronic disability. The advances in the medical management of stroke patients over the past decade have significantly reduced mortality, but at the same time increased numbers of disabled survivors. Unfortu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2016.08.029

    authors: Alawieh A,Zhao J,Feng W

    更新日期:2018-03-15 00:00:00

  • Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice.

    abstract::NC-1900, an active fragment analog of arginine vasopressin [arginine vasopressin-(4-9)], has proved to be capable of improving the spatial memory deficits and the impairments in passive avoidance test. In this study, a novel drug carrier for brain delivery, cationic bovine serum albumin conjugated pegylated nanopartic...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.06.001

    authors: Xie YL,Lu W,Jiang XG

    更新日期:2006-10-02 00:00:00

  • Testing the role of reward and punishment sensitivity in avoidance behavior: a computational modeling approach.

    abstract::Exaggerated avoidance behavior is a predominant symptom in all anxiety disorders and its degree often parallels the development and persistence of these conditions. Both human and non-human animal studies suggest that individual differences as well as various contextual cues may impact avoidance behavior. Specifically...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.01.033

    authors: Sheynin J,Moustafa AA,Beck KD,Servatius RJ,Myers CE

    更新日期:2015-04-15 00:00:00

  • Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

    abstract::Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.05.008

    authors: Bour A,Grootendorst J,Vogel E,Kelche C,Dodart JC,Bales K,Moreau PH,Sullivan PM,Mathis C

    更新日期:2008-11-21 00:00:00

  • Olfaction directs skilled forelimb reaching in the rat.

    abstract::Rats were trained to reach for food pellets, which varied in size from 20 to 300 mg, from one of 21 locations on a shelf located just outside a test cage. After a barrier was lifted, giving access to a food pellet, latency to contact the food was timed, number of reaches to contact the food were counted, the distance ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(89)80067-1

    authors: Whishaw IQ,Tomie JA

    更新日期:1989-02-01 00:00:00

  • Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity.

    abstract::The aim of this study was to examine the effect of a polyphenol-rich extract (PrB) of Vaccinium angustifolium (wild blueberries) introduced intraperitoneally (i.p.) at 30 (PrB30) and 60 (PrB60) mg/kg body weight for 7 days, on cognitive performance, brain oxidative status and acetylcholinesterase activity in adult, ma...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.11.013

    authors: Papandreou MA,Dimakopoulou A,Linardaki ZI,Cordopatis P,Klimis-Zacas D,Margarity M,Lamari FN

    更新日期:2009-03-17 00:00:00

  • Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression.

    abstract::Amphetamine (AMPH) is known as an anorectic agent. Repeated treatments of AMPH for several days induced a marked anorexia on day 1 followed by a gradual return of food intake to normal level. Previously, using daily food intake (DFI) as an indicator, we found that both dopamine (DA) D1 and D2 receptors were involved i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2003.04.001

    authors: Kuo DY

    更新日期:2003-12-17 00:00:00

  • Administration of N-acetylserotonin and melatonin alleviate chronic ketamine-induced behavioural phenotype accompanying BDNF-independent and dependent converging cytoprotective mechanisms in the hippocampus.

    abstract::Though growing evidence implicates both melatonin (MLT) and its immediate precursor N-acetylserotonin (NAS) in the regulation of hippocampal neurogenesis, their comparative mechanistic relationship with core behavioural correlates of psychiatric disorders is largely unknown. To address this issue, we investigated the ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.10.027

    authors: Choudhury A,Singh S,Palit G,Shukla S,Ganguly S

    更新日期:2016-01-15 00:00:00

  • Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.

    abstract::Prepulse inhibition (PPI) of acoustic startle response is a valuable paradigm for sensorimotor gating processes. Previous research showed that acute administration of St. John's wort extract (500 mg/kg, p.o.) to rats caused significant disruption of PPI while elevating monoamines levels in some brain areas. The cause-...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.12.015

    authors: Tadros MG,Mohamed MR,Youssef AM,Sabry GM,Sabry NA,Khalifa AE

    更新日期:2009-05-16 00:00:00

  • The therapeutic effects of dopamine replacement therapy and its psychiatric side effects are mediated by pineal function.

    abstract::There are reports that melatonin secretion from the pineal gland gradually diminishes with advancing age. It has been suggested that various forms of neuropsychiatric disease, in particular, Parkinson's disease (PD), is consequentially related to this decrease by virtue of increased oxidative stress which enhances the...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.11.030

    authors: Willis GL

    更新日期:2005-05-07 00:00:00

  • Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus.

    abstract::Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals, including humans. Thus, it is extremely important to prevent memory decline for increasing healthy aging. Ginsenoside, the effective ingredient of ginseng, has been re...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.03.002

    authors: Zhao H,Li Q,Pei X,Zhang Z,Yang R,Wang J,Li Y

    更新日期:2009-08-12 00:00:00

  • Impaired microglia fractalkine signaling affects stress reaction and coping style in mice.

    abstract::Microglia, resident immune cells of the CNS are sensitive to various perturbations of the environment, such as stress exposure, and may be involved in translating these changes to behavior. Among the pathways mediating stress-related neuronal cues to microglia, the fractalkine-fractalkine receptor (CX3CR1) signaling p...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.07.023

    authors: Winkler Z,Kuti D,Ferenczi S,Gulyás K,Polyák Á,Kovács KJ

    更新日期:2017-09-15 00:00:00

  • Sensitivity of modified Biel-maze task, compared with Y-maze task, to measure spatial learning and memory deficits of ethanol teratogenicity in the guinea pig.

    abstract::Ethanol consumption during pregnancy can produce a variety of teratogenic effects in offspring, termed Fetal Alcohol Spectrum Disorders (FASD). The most debilitating and permanent consequence of chronic prenatal ethanol exposure (CPEE) is neurobehavioral teratogenicity, which often manifests as cognitive and behaviora...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.04.042

    authors: Dobson CC,Mongillo DL,Poklewska-Koziell M,Winterborn A,Brien JF,Reynolds JN

    更新日期:2012-07-15 00:00:00

  • Postural performance in decerebrated rabbit.

    abstract::It is known that animals decerebrated at the premammillary level are capable of standing and walking without losing balance, in contrast to postmammillary ones which do not exhibit such behavior. The main goals of the present study were, first, to characterize the postural performance in premammillary rabbits, and, se...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.02.011

    authors: Musienko PE,Zelenin PV,Lyalka VF,Orlovsky GN,Deliagina TG

    更新日期:2008-06-26 00:00:00

  • Behavioral characterization of dysbindin-1 deficient sandy mice.

    abstract::Dysbindin-1 (dystrobrevin binding protein-1) has been reported as a candidate gene associated with schizophrenia. Dysbindin-1 mRNA and protein levels are significantly reduced in the prefrontal cortex and hippocampus of schizophrenia subjects. To understand the in-vivo functions of dysbindin-1, we studied schizophreni...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.10.011

    authors: Bhardwaj SK,Baharnoori M,Sharif-Askari B,Kamath A,Williams S,Srivastava LK

    更新日期:2009-02-11 00:00:00

  • Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.

    abstract::Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 199...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.03.025

    authors: Castillo CG,Mendoza S,Freed WJ,Giordano M

    更新日期:2006-07-15 00:00:00

  • Celecoxib delays cognitive decline in an animal model of neurodegeneration.

    abstract::Cyclooxygenase-2 (COX-2) is thought to play a role in the pathogenesis of various neurodegenerative disorders. However, clinical trials with COX-2 inhibitors have yielded contradictory results. In the present study we investigated whether COX-2 plays a role in the behavioral and cognitive impairments seen in olfactory...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.07.007

    authors: Borre Y,Lemstra S,Westphal KG,Morgan ME,Olivier B,Oosting RS

    更新日期:2012-10-01 00:00:00

  • Altered reward sensitivity in female offspring of cocaine-exposed fathers.

    abstract::Recent rodent studies have demonstrated that parental cocaine exposure can influence offspring behavior, supporting the idea that environmental insults can impact subsequent generations. However, studies on the effects of paternal cocaine exposure are limited and multiple inconsistencies exist. In the current study, w...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.05.054

    authors: Fischer DK,Rice RC,Martinez Rivera A,Donohoe M,Rajadhyaksha AM

    更新日期:2017-08-14 00:00:00

  • Visual evoked potentials in rats selected for high or low self-stimulation.

    abstract::Visual evoked potentials (VEPs) were analyzed in order to distinguish between rats from genetically high (HI) and low (LO) self-stimulation lines (LC2-HI and LC2-LO). Secondary VEP components - slow secondary negative wave (SNW) and sensory afterdischarge (SAD) - which are considered to be most sensitive indices of no...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90137-2

    authors: Myslobodsky MS,Levin D

    更新日期:1984-02-01 00:00:00

  • Not all stress is equal: CREB is not necessary for restraint stress reinstatement of cocaine-conditioned reward.

    abstract::Stress elicits relapse to cocaine seeking in humans and in animal models. Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. However, the role of CREB in other stress-induced reinstatement models has not been examined. To determ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.02.026

    authors: Briand LA,Blendy JA

    更新日期:2013-06-01 00:00:00

  • Orientational asymmetries in small-field optokinetic nystagmus in human infants.

    abstract::Optokinetic nystagmus (OKN) is a pattern of reflexive eye movements which occurs when portions of the visual field are in continuous motion. Gratings moving at 7 deg/s either horizontally (left or right) or vertically (up or down) were presented on a viewing screen subtending 30 degrees by 22 degrees. Horizontal (HOKN...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90164-5

    authors: Hainline L,Lemerise E,Abramov I,Turkel J

    更新日期:1984-09-01 00:00:00

  • Reduction of GABAergic neurons within the tectofugal visual system of white zebra finches.

    abstract::The central visual system of white zebra finches is physiologically and anatomically different from normally coloured (wild type) animals. The main difference to normal birds is an enhanced response to ipsilateral stimulation in all areas of the tectofugal visual pathway. Previous experiments indicated that besides an...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.02.016

    authors: Wonderschütz P,Bischof HJ

    更新日期:2006-06-03 00:00:00

  • Lesion of the isthmo-optic nucleus impairs target selection for visually guided reaching.

    abstract::Neurons in the isthmo-optic nucleus (ION) of the avian midbrain receive input predominantly from the ipsilateral optic tectum and project to the contralateral retina. Therefore, lesion in the ION removes tectal efferent signals to the retina in birds. In the present study, we trained Japanese quail to reach a target s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.05.008

    authors: Uchiyama H,Ohno H,Kodama R

    更新日期:2012-08-01 00:00:00

  • Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine.

    abstract::GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits. The predominant neuronal GABAB1 subunit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.10.039

    authors: Jacobson LH,Sweeney FF,Kaupmann K,O'Leary OF,Gassmann M,Bettler B,Cryan JF

    更新日期:2016-02-01 00:00:00

  • Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders.

    abstract::Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKIvarepsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has been implicated in human sleep disorders. Here, we investigated the CKIvarepsilon...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.05.005

    authors: Castro RM,Barbosa AA,Pedrazzoli M,Tufik S

    更新日期:2008-11-03 00:00:00

  • Prepulse inhibition of the acoustic startle reflex in pigs and its disruption by d-amphetamine.

    abstract::Prepulse inhibition (PPI) of the startle reflex is an operational measure of sensorimotor gating. The dopamine receptor agonist-mediated disruption of PPI in rats is widely used as a model of the sensorimotor gating deficiencies demonstrated in schizophrenia patients. As a possible tool for validation of a pig model o...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.04.014

    authors: Lind NM,Arnfred SM,Hemmingsen RP,Hansen AK

    更新日期:2004-12-06 00:00:00

  • Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task.

    abstract::Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seve...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00186-3

    authors: Popoviç M,Biessels GJ,Isaacson RL,Gispen WH

    更新日期:2001-08-01 00:00:00