Abstract：
:We have reported previously that exposure to the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) during the neonatal period causes cognitive impairments in adult rats. The aim of this study was to investigate the long-term effects of neonatal BMAA exposure on learning and memory mechanisms and to identify early morphological changes in the neonatal brain. BMAA was injected subcutaneously in rat pups on postnatal days 9-10. BMAA (50 and 200 mg/kg) caused distinct deficits in spatial learning and memory in adult animals but no morphological changes. No impairment of recognition memory was detected, suggesting that neonatal exposure to BMAA preferentially affects neuronal systems that are important for spatial tasks. Histopathological examination revealed early neuronal cell death as determined by TUNEL staining in the hippocampus 24 h after a high dose (600 mg/kg) of BMAA whereas no changes were observed at lower doses (50 and 200 mg/kg). In addition, there was a low degree of neuronal cell death in the retrosplenial and cingulate cortices, areas that are also important for cognitive function. Taken together, these results indicate that BMAA is a developmental neurotoxin inducing long-term changes in cognitive function. The risk posed by BMAA as a potential human neurotoxin merits further consideration, particularly if the proposed biomagnifications in the food chain are confirmed.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Karlsson O,Roman E,Berg AL,Brittebo EBdoi
10.1016/j.bbr.2011.01.056subject
Has Abstractpub_date
2011-06-01 00:00:00pages
310-20issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00097-0journal_volume
219pub_type
杂志文章abstract：:Impairments in attention/vigilance and response disinhibition are commonly observed in several neuropsychiatric disorders. Validating animal models could help in developing therapeutics for cognitive deficits and improving functional outcomes in such disorders. The 5-choice continuous performance test (5C-CPT) in mice...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2011-09-12 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-01-15 00:00:00
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更新日期：2003-09-15 00:00:00
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更新日期：2012-04-15 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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更新日期：2013-01-15 00:00:00
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journal_title：Behavioural brain research
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更新日期：2014-01-01 00:00:00
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更新日期：2006-04-25 00:00:00
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pub_type： 杂志文章
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更新日期：1990-12-21 00:00:00
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更新日期：2011-01-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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pub_type： 杂志文章
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