Abstract：
:We examined the Trail Making Test (TMT) in a sample of 767 participants with prodromal Huntington disease (prodromal HD) and 217 healthy comparisons to determine the contributions of motor, psychiatric, and cognitive changes to TMT scores. Eight traditional and derived TMT scores were also evaluated for their ability to differentiate prodromal participants closer to estimated age of diagnosis from those farther away and prodromal individuals from healthy comparisons. Results indicate that motor signs only mildly affected Part A, and psychiatric symptoms did not affect either part. Tests of perceptual processing, visual scanning, and attention were primarily associated with Part A, and executive functioning (response inhibition, set-shifting), processing speed, and working memory were associated with Part B. Additionally, TMT scores differentiated between healthy comparisons and prodromal HD individuals as far as 9-15 years before estimated diagnosis. In participants manifesting prodromal motor signs and psychiatric symptoms, the TMT primarily measures cognition and is able to discriminate between groups based on health status and estimated time to diagnosis.
journal_name
J Clin Exp Neuropsycholjournal_title
Journal of clinical and experimental neuropsychologyauthors
O'Rourke JJ,Beglinger LJ,Smith MM,Mills J,Moser DJ,Rowe KC,Langbehn DR,Duff K,Stout JC,Harrington DL,Carlozzi N,Paulsen JSdoi
10.1080/13803395.2010.541228subject
Has Abstractpub_date
2011-06-01 00:00:00pages
567-79issue
5eissn
1380-3395issn
1744-411Xpii
933217830journal_volume
33pub_type
杂志文章abstract：:The Modified Mini-Mental State Examination (3MS) is an expanded and modified version of the Mini-Mental Status Exam (MMSE). Although the MMSE has achieved widespread clinical use as a brief cognitive screen, the utility of the measure to ascertain cognitive impairment is constrained by a limited set of abilities sampl...
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