The diagnostic assessment of canine lymphoma: implications for treatment.

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in the healthy newborn, occurring in 1 in 1000 live births. NAIT is analogous to rhesus alloimmunization in pathophysiology; however, it often presents unexpectedly in first pregnancies. Presentation of NAIT varies from mil...

journal_title：Clinics in laboratory medicine

authors： Strong NK,Eddleman KA

更新日期：2013-06-01 00:00:00

abstract：:Antiretroviral failure caused by the development of drug resistance in HIV-1 is an increasingly common clinical problem. Two types of resistance assays are available to clinicians. Genotypic assays determine the presence of mutations associated with drug resistance. The interpretation of mutations is often complicated...

journal_title：Clinics in laboratory medicine

authors： Hanna GJ

更新日期：2002-09-01 00:00:00

abstract：:With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive mi...

journal_title：Clinics in laboratory medicine

authors： Smith KP,Kirby JE

更新日期：2019-09-01 00:00:00

abstract：:The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...

journal_title：Clinics in laboratory medicine

authors： Canick JA,Kellner LH,Bombard AT

更新日期：2003-06-01 00:00:00

abstract：:From the inception of TBS in 1988, it has been well received by the pathology and clinical communities. The need for a unifying system of nomenclature was so great that most of the laboratories in the United States, as well as in numerous countries worldwide, quickly adopted TBS. By 1991, only 2 years after the initia...

journal_title：Clinics in laboratory medicine

authors： Henry MR

更新日期：2003-09-01 00:00:00

abstract：:This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...

journal_title：Clinics in laboratory medicine

authors： Spring JL,Winkler A,Levy JH

更新日期：2014-09-01 00:00:00

abstract：:Market forces and service demands are driving a segment of laboratory testing away from centralized laboratories and closer to the patient's bedside. Placed into a historical perspective, this should be neither surprising nor distressing. Terminology is being clarified and professional societies are beginning to take ...

journal_title：Clinics in laboratory medicine

authors： Handorf CR

更新日期：1994-09-01 00:00:00

abstract：:At the present time, the use of molecular techniques for diagnosing the neurologic porphyrias is limited mainly to those laboratories doing research in the area. Because any of four genes may be involved, it is important to confirm the diagnosis in the index case before undertaking molecular investigation. With advanc...

journal_title：Clinics in laboratory medicine

authors： Schreiber WE

更新日期：1997-03-01 00:00:00

abstract：:The classic workup of a patient for possible PA is revisited in light of the vanishing Schilling test. The vagaries of testing for B12 and blocking antibodies are reexamined. The advantages and disadvantages of newer tests such as MMA and serum gastrin levels are catalogued. At this juncture in the evolution of new te...

journal_title：Clinics in laboratory medicine

authors： Ward PC

更新日期：2002-06-01 00:00:00

abstract：:The most efficacious and practical means of diagnosing human schistosomiasis is based on the detection of infection-specific antibodies. Because of their high sensitivity, antibody assays remain the most practical assays for epidemiologic studies and patient management. Initial screening may be performed in the field ...

journal_title：Clinics in laboratory medicine

authors： Tsang VC,Wilkins PP

更新日期：1991-12-01 00:00:00

abstract：:Revolutionary changes in the computer industry brought about in part by the introduction of personal computers are now reaching into clinical laboratories everywhere. Although the true justification for any computer tool may be an intangible one such as improvement in service, such tools can typically be cost justifie...

journal_title：Clinics in laboratory medicine

authors： Hendricks EJ

更新日期：1985-12-01 00:00:00

abstract：:Advances in computing speed and power have made a pure digital work flow for pathology. New technologies such as whole slide imaging (WSI), multispectral image analysis, and algorithmic image searching seem poised to fundamentally change the way in which pathology is practiced. This article provides the practicing pat...

journal_title：Clinics in laboratory medicine

authors： Park S,Pantanowitz L,Parwani AV

更新日期：2012-12-01 00:00:00

abstract：:To date, CRP remains the single standard biochemical marker for predicting the severity of AP. Because the combination of clinico-physiological scores and CRP provides good information at 48 hours, research has focused on the predictive ability of various markers when applied in the initial 24 hours after admission to...

journal_title：Clinics in laboratory medicine

authors： Papachristou GI,Whitcomb DC

更新日期：2005-03-01 00:00:00

abstract：:Technical aspects of rare-event detection are discussed in this article in a practical context, with two real-life examples. A growing number of flow cytometry-based assays depend on rare-event detection for basic science and clinical applications. ...

journal_title：Clinics in laboratory medicine

authors： Donnenberg AD,Donnenberg VS

更新日期：2007-09-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs attributed to large or small vessel thrombosis or, in some instances, possible nonthrombotic inflammatory mechanisms, associated with in vitro evidence of antibodies to certain proteins, or proteinphospholipid...

journal_title：Clinics in laboratory medicine

authors： Eby C

更新日期：2009-06-01 00:00:00

abstract：:Seven different mycoplasmas have been isolated from the human genitourinary tract. The diseases they cause or with which they have been associated are described. Diagnosis of infection by cultural and noncultural (antigen detection, DNA probes) methods is discussed in detail. The more useful serologic procedures are i...

journal_title：Clinics in laboratory medicine

authors： Taylor-Robinson D

更新日期：1989-09-01 00:00:00

abstract：:Granulocytic sarcoma is a variant presentation of acute myeloblastic leukemia, occurring in extramedullary locations. It is uncommon, but it may occur at any site and at any age, which necessitates its inclusion in the differential diagnosis of all undifferentiated tumors. Histology, touch-imprint cytology, cytochemis...

journal_title：Clinics in laboratory medicine

authors： Hutchison RE,Kurec AS,Davey FR

更新日期：1990-12-01 00:00:00

abstract：:ALP is a profoundly ubiquitous enzyme that originates in many, if not all, mammalian tissues. The development of a simple ISEF technique has allowed reflection of at least 12 cellular components. Improvements in technique may add further zones of information. The aura of darkness surrounding ALP is being slowly dissip...

journal_title：Clinics in laboratory medicine

authors： Griffiths J

更新日期：1989-12-01 00:00:00

abstract：:Several major pet-food and human-food safety incidents occurred worldwide between 2003 and 2008, causing illnesses and deaths in children, cats, dogs, and pigs. During the 2007 outbreak of renal failure in dogs and cats in the United States, veterinary diagnostic laboratories helped identify melamine and melamine anal...

journal_title：Clinics in laboratory medicine

authors： Puschner B,Reimschuessel R

更新日期：2011-03-01 00:00:00

abstract：:Image processing applications in forensic pathology are becoming increasingly important. This article introduces basic concepts in image processing as applied to problems in forensic pathology in a non-mathematical context. Discussions of contrast enhancement, digital encoding, compression, deblurring, and other topic...

journal_title：Clinics in laboratory medicine

authors： Oliver WR

更新日期：1998-03-01 00:00:00

abstract：:Pet guinea pigs are presented to veterinary clinics for routine care and treatment of clinical diseases. In addition to obtaining clinical history and exam findings, diagnostic testing may be required, including hematological assessments. This article describes common blood collection methods, including venipuncture s...

journal_title：Clinics in laboratory medicine

authors： Zimmerman K,Moore DM,Smith SA

更新日期：2015-09-01 00:00:00

abstract：:A rapidly increasing body of evidence links human papillomavirus (HPV) to cervical neoplasia through epidemiologic associations, pathologic features, molecular detection, and mechanisms of oncogenesis. HPV is now accepted as the primary cause of cervical neoplasia and accounts for most of the risk factors traditionall...

journal_title：Clinics in laboratory medicine

authors： McLachlin CM

更新日期：2000-06-01 00:00:00

abstract：:FNA cytology has been shown to be highly accurate in diagnosing malignant tumors. In gynecology, an overall accuracy of 94.5% in the differentiation between benign and malignant tumors has been reported. Despite many controversial views regarding its safety, aspiration cytology has been accepted as an innocuous proced...

journal_title：Clinics in laboratory medicine

authors： Ganjei P

更新日期：1995-09-01 00:00:00

abstract：:Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological un...

journal_title：Clinics in laboratory medicine

authors： Strotman LN,Linder MW

更新日期：2016-09-01 00:00:00

abstract：:An ideal immunohistochemical screening panel would be one in which each antibody is 100% sensitive and specific for the target cell type (e.g., markers for epithelial neoplasms, lymphomas, sarcomas, etc.). Anyone who has practiced immunochemistry is well aware that this situation does not exist. High sensitivity is hi...

journal_title：Clinics in laboratory medicine

authors： Linder J

更新日期：1990-03-01 00:00:00

abstract：:B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type. In this...

journal_title：Clinics in laboratory medicine

authors： Hope CB,Pincus LB

更新日期：2017-09-01 00:00:00

abstract：:The last decade has witnessed the transformation of first-trimester Down syndrome screening from an aspiration to a clinical reality. First-trimester screening now equals or exceeds the diagnostic accuracy of conventional midtrimester screen while realizing an important desire of pregnant women for early diagnosis. Be...

journal_title：Clinics in laboratory medicine

authors： Bahado-Singh RO,Argoti P

更新日期：2010-09-01 00:00:00

abstract：:Rapidly changing technology in the clinical microbiology laboratory requires a highly skilled workforce. The current clinical microbiology workforce is aging with a wave of retirements currently unfolding. Key competencies that will be needed for the next generation of microbiologists include strong analytical skills,...

journal_title：Clinics in laboratory medicine

authors： Gilligan PH,McGee MH

更新日期：2019-09-01 00:00:00

abstract：:A decision model was developed to evaluate the costs and benefits of further reducing the risk of transfusion-transmitted disease. The model addresses recipient risk factors as well as operational considerations. Application of the model to prior risk reduction decisions documents its validity as a decision-making too...

journal_title：Clinics in laboratory medicine

authors： Hanson M

更新日期：1996-12-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...

journal_title：Clinics in laboratory medicine

authors： Dingle TC,Butler-Wu SM

更新日期：2013-09-01 00:00:00