Abstract：
BACKGROUND/OBJECTIVES:Vitamin D mediates immunomodulatory functions, and its deficiency has been associated with an increased prevalence of immunological diseases. The supplementation of vitamin D might be therapeutically beneficial, for example, in lupus erythematosus patients. However, its affect on established recall immune responses is undefined. SUBJECTS/METHODS:In all, 32 individuals were randomized in a placebo controlled, double-blind setting, and received vitamin D (daily 2000 IU) for 10 weeks followed by tetanus toxoid (TT) booster immunization. RESULTS:During vitamin D supplementation the median 25-hydroxyvitamin D serum concentration increased to 80.3 nM, which as expected decreased in the placebo group to 29.1 nM during the ultraviolet-deprived winter months. The TT-specific immunoglobulin G (IgG) boost efficiency was marginal higher in the vitamin D group (P = 0.04). The increase of the 25-hydroxyvitamin D levels correlated with the increase of TT-IgG serum concentrations. The induction of specific serum IgA and specific antibody secreting cells was comparable between both groups. Accordingly, the TT-specific and polyclonally triggered T-cell cytokine profiles were stable as well. CONCLUSIONS:Vitamin D supplementation was successful and booster immunization induced efficiently specific antibodies titers.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Heine G,Drozdenko G,Lahl A,Unterwalder N,Mei H,Volk HD,Dörner T,Radbruch A,Worm Mdoi
10.1038/ejcn.2010.276subject
Has Abstractpub_date
2011-03-01 00:00:00pages
329-34issue
3eissn
0954-3007issn
1476-5640pii
ejcn2010276journal_volume
65pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. DESIGN:In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Dat...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601909
更新日期：2004-06-01 00:00:00
abstract：:Diet may both increase and decrease oxidative stress in the body. We compared the effects of four strictly controlled isocaloric diets with different intakes of polyunsaturated fatty acids (PUFA, 11 or 3% of energy) and vegetables and fruit (total amount of vegetables and fruit 516 or 1059 g/10 MJ) on markers associat...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：10.1038/sj.ejcn.1602865
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:To study dietary lipid intake and plasma lipid profile of the Hong Kong Chinese population as part of a territory wide survey on cardiovascular risk factors. DESIGN:Randomised age and sex stratified survey. SUBJECTS:1010 subjects aged 25-74 y (500 men, 510 women). MEASUREMENTS:A food frequency method with ...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1600430
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. DESIGN:Double-blind, randomised, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION:A total of 55 healthy volunteers (n=20 males, n=35 fe...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602132
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To assess dietary patterns (DPs) in European adolescents and to examine their relationship with several indicators of sedentary behaviour. SUBJECTS/METHODS:A multinational cross-sectional study was carried out in 2202 adolescents (45.4% boys) aged 12.5-17.5 years. A self-reported questionnaire wi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.170
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abstract：OBJECTIVES:To describe average levels of free-living energy expenditure in people from affluent societies and to determine the influence of body weight, height, age and sex. DESIGN:Analysis of 574 measurements of total energy expenditure (TEE, assessed by the doubly-labelled water method); basal metabolic rate (BMR, d...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults. DESIGN:A double-blind, placebo-controlled, crossover human study. SETTING:Food Microbial Sciences Unit, The University of Reading, Reading, UK. SUBJECTS:Thirty healthy volunteers, 15 men, 15 women (age range 19-35). INTERVEN...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602636
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVES:To identify the types and quantities of 'extra' foods, or energy-dense, nutrient-poor foods, consumed by Australian adults, and assess their contribution to total energy and nutrient intakes. SUBJECT/METHODS:We used 24-h recall data from 10 851 adults, aged 19 years and over, who participated in the nationa...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2008.51
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602790
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy is known to increase oxidative stress, which may influence pregnancy outcomes and health of the child. SUBJECTS/METHODS:This study investigated whether fruit and vegetable intake modifies the relationship between exposure to PAH...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.77
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Snacking has increased globally. We examine snacking patterns and common snack foods in Brazil. SUBJECTS/METHODS:Data from the first of two non-consecutive food diaries from 34,003 individuals (aged ≥ 10 years) in the first Brazillian nationally representative dietary survey (2008-2009) were used...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.60
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abstract：OBJECTIVE:To determine if changes in serum homocysteine values during folic acid supplementation can identify objectively healthy subjects with subclinical folate deficiency. DESIGN:Blood drawn and processed in a regimented fashion from fasting subjects. Serum homocysteine values determined by gas chromatography-mass ...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
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更新日期：1997-03-01 00:00:00
abstract：OBJECTIVES:To explore the different characteristics of high and low fat consumers, in particular their macronutrient intake and body mass index. DESIGN:Reanalysis of data from the Dietary and Nutritional Survey of British Adults. Comparisons were made between groups defined as high and low fat consumers on the basis o...
journal_title：European journal of clinical nutrition
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doi：
更新日期：1996-08-01 00:00:00
abstract：:The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：1997-05-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
