Placebo-controlled trial of misoprostol in cystic fibrosis.

Abstract:

:Seventeen children with cystic fibrosis were studied in a 6-week double-blind, placebo-controlled, crossover trial to determine the efficacy of misoprostol, 100 micrograms, four times a day, in improving fat absorption in patients already on pancreatic enzyme therapy. In those patients who had greater than 90% absorption on enzyme therapy alone, no further significant increase in absorption was achieved with misoprostol administration. Those patients who had absorption of less than 90% on standard enzyme therapy showed a significant improvement with misoprostol administration (p less than 0.01). One patient had a significant elevation in the eosinophil count during the period of misoprostol administration, but there were no significant changes in any other hematological or biochemical parameter. Misoprostol appears to be of benefit to those children with cystic fibrosis who have residual malabsorption on standard enzyme therapy.

authors

Robinson P,Sly PD

doi

10.1097/00005176-199007000-00007

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

37-40

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

11

pub_type

临床试验,杂志文章
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  • Tolerability, safety, and efficacy of PEG 3350 as a 1-day bowel preparation in children.

    abstract:OBJECTIVE:The aim of the study was to evaluate the tolerability, safety, and efficacy of polyethylene glycol (PEG) 3350 without electrolytes as a 1-day bowel preparation for colonoscopy in children. METHODS:A prospective study of 45 children undergoing colonoscopy prescribed PEG 3350 without electrolytes mixed with a ...

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  • Extensive and partial protein hydrolysate preterm formulas: the effect on growth rate, protein metabolism indices, and plasma amino acid concentrations.

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    authors: Szajewska H,Albrecht P,Stoitiska B,Prochowska A,Gawecka A,Laskowska-Klita T

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    abstract::Hepatocytes differ in their metabolism depending on their position in the liver acinus. To assess how such specialization changes during development, we used quantitative cytochemistry to measure succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), glucose-6-phosphatase (G6P), and NADPH dehydrogenase (ND) act...

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    pub_type: 杂志文章

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    更新日期:1989-05-01 00:00:00

  • Enzymes in mother's milk and their possible role in digestion.

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    pub_type: 杂志文章

    doi:10.1097/00005176-198300201-00015

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    更新日期:1983-01-01 00:00:00

  • Plasma amino acid response to ingestion of L-amino acids and whole protein.

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    pub_type: 杂志文章

    doi:10.1097/00005176-199302000-00008

    authors: Gropper SS,Gropper DM,Acosta PB

    更新日期:1993-02-01 00:00:00

  • What is the evidence on the practice of mucous fistula refeeding in neonates with short bowel syndrome?

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    pub_type: 杂志文章,评审

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    更新日期:2006-08-01 00:00:00

  • Comparison of oral sodium phosphate to polyethylene glycol-based solution for bowel preparation for colonoscopy in children.

    abstract::Thirty-four patients, aged 3 to 17 years, were randomized to receive oral sodium phosphate solution or a polyethylene glycol-based solution in preparation for elective colonoscopy. Nineteen patients received two doses of oral sodium phosphate solution (45 mL/1.7 m2/ dose) and 15 received polyethylene glycol-based solu...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199612000-00013

    authors: Gremse DA,Sacks AI,Raines S

    更新日期:1996-12-01 00:00:00

  • Effect of gum arabic in an oral rehydration solution on recovery from diarrhea in rats.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00005176-198801000-00020

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    更新日期:1988-01-01 00:00:00

  • Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference.

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    pub_type: 共识发展会议,杂志文章

    doi:10.1097/MPG.0000000000001564

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  • Growth Pattern in Paediatric Crohn Disease Is Related to Inflammatory Status.

    abstract:OBJECTIVES:The respective role of disease activity and steroid therapy in growth impairment in paediatric-onset Crohn disease (CD) is still debated. Our aim was to investigate whether the growth pattern of children with CD was correlated with the inflammatory status during the disease course, regardless the cumulative ...

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章

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    更新日期:1984-06-01 00:00:00

  • Implementation of a Timed Barium Esophagram Protocol for Assessment of Esophageal Function in Children.

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002829

    authors: Rosenwald KD,Hayes K,Menard-Katcher C,Belkind-Gerson J

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  • Bilirubinuria: an early indicator of gallbladder hydrops associated with Kawasaki disease.

    abstract::We report four cases of gallbladder hydrops associated with Kawasaki disease diagnosed over a 7.5 year period. Despite varying clinical presentations, all four of these patients had the common finding of bilirubinuria prior to clinical symptoms or at the time of admission. Review of 40 other cases of Kawasaki disease ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Friesen CA,Gamis AS,Riddell LD,Roberts CC,Jackson MA

    更新日期:1989-04-01 00:00:00

  • Prevention of rotavirus-induced diarrhea by preferential secretion of IgA in breast milk via maternal administration of Lactobacillus gasseri SBT2055.

    abstract:OBJECTIVES:Rotavirus (RV)-induced diarrhea poses a major health problem, particularly to infants. An effective measure to prevent RV infection is to consume breast milk with higher levels of protective IgA. We therefore examined whether Lactobacillus gasseri SBT2055 (LG2055) could augment immunoglobulin (Ig) A levels a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182533a2b

    authors: Kadooka Y,Tominari K,Sakai F,Yasui H

    更新日期:2012-07-01 00:00:00

  • Dietary intake of polyunsaturated fatty acids among breast-feeding and non-breast-feeding 24- to 48-month-old children in Bangladesh.

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182042bc8

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    更新日期:2011-03-01 00:00:00

  • Occult Blood and Perianal Examination: Value Added in Pediatric Inflammatory Bowel Disease Screening.

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    pub_type: 杂志文章

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    更新日期:2015-07-01 00:00:00

  • The complexity of feeding problems in 700 infants and young children presenting to a tertiary care institution.

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200307000-00014

    authors: Rommel N,De Meyer AM,Feenstra L,Veereman-Wauters G

    更新日期:2003-07-01 00:00:00

  • Indomethacin, dexamethasone, and intestinal damage in infant rats.

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200208000-00010

    authors: Patel MR,DeMarco VG,Clare-Salzler M,Li YY,Neu J

    更新日期:2002-08-01 00:00:00

  • Dietary regulation of intestinal lactase and sucrase in adult rats: quantitative comparison of effect of lactose and sucrose.

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    pub_type: 杂志文章

    doi:10.1097/00005176-198512000-00024

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    更新日期:1985-12-01 00:00:00

  • Assessment of the rectoanal inhibitory reflex in preterm infants with delayed meconium passage.

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000150420.00161.b9

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  • Acute phase proteins in chronic inflammatory bowel disease in childhood.

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    pub_type: 杂志文章

    doi:10.1097/00005176-198201020-00007

    authors: Campbell CA,Walker-Smith JA,Hindocha P,Adinolfi M

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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