Expression of placental growth factor in regenerating livers after partial hepatectomy in the rat.

Abstract:

BACKGROUND/AIMS:Placental growth factor (PlGF) is known for its role in pathological conditions to protect parenchymal cells of different organs from injury, whereas its presence in the liver and its potential importance in stimulating liver regeneration has never been described. This was investigated in this study using a rat model of partial hepatectomy (PH). METHODS:The rat model of 70, 80, and 90% PH was used. Liver samples were taken peroperatively, 1 h, 1, 2, 3, and 7 days after surgery. Liver regeneration was evaluated by liver weight/body weight ratio, liver regeneration rate (%), and proliferating cell marker Ki67. The expression of PlGF, vascular endothelial growth factor (VEGF), VEGF receptor 1 (Flt-1), VEGF receptor 2 (Flk-1), and hypoxia inducible factor-1α mRNA was measured by quantitative real-time PCR and localized by immunohistochemistry. RESULTS:The mRNA expression of PlGF was upregulated immediately after PH. Compared with 70 and 80% PH groups, the 90% PH group had a significantly lower PlGF and hypoxia inducible factor-1α mRNA expression, in parallel to a delayed liver weight/body weight ratio recovery. Only little differences were observed in VEGF, Flt-1, and Flk-1 mRNA expression among the PH groups. CONCLUSION:This study shows for the first time the PlGF upregulation in regenerating livers, which is related to hypoxia stimulation and liver growth. The swift PlGF upregulation immediately after PH may indicate an important role for the PlGF/Flt-1 pathway in the early stage of liver regeneration.

authors

Vanheule E,Fan YD,Van Huysse J,Meester D,Olievier K,Praet M,de Hemptinne B,Colle I

doi

10.1097/MEG.0b013e328341ef35

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

66-75

issue

1

eissn

0954-691X

issn

1473-5687

journal_volume

23

pub_type

杂志文章
  • Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.

    abstract::Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0b013e32833b00f9

    authors: Dongbin L,Fei L,Werner Josefin B,Roland A

    更新日期:2010-09-01 00:00:00

  • Prescribing habits in primary biliary cirrhosis: a national survey.

    abstract:BACKGROUND:Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown aetiology. A number of drugs have been used in its treatment, but only ursodeoxycholic acid (UDCA) has been shown to improve survival. Our aims were to determine the current prescribing habits in PBC of all practising gastroent...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199908000-00001

    authors: Verma A,Jazrawi RP,Ahmed HA,Northfield TC

    更新日期:1999-08-01 00:00:00

  • Prevention of rebleeding from oesophageal-gastric varices.

    abstract::Endoscopic sclerotherapy or ligation and/or drugs are the standard treatments for the prevention of variceal rebleeding. Failure of this treatment indicates the need for rescue transjugular intrahepatic portosystemic shunt (TIPS) implantation. The current practice to use endoscopic treatment as first-line and TIPS as ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200104000-00007

    authors: Rössle M

    更新日期:2001-04-01 00:00:00

  • Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis: an observational study with a systematic review of the literature.

    abstract:BACKGROUND:Until now, no data on the routine screening for thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis (PVT) have been reported. METHODS:A total of 141 nonmalignant and noncirrhotic patients with PVT who underwent screening tests for thrombotic risk factors bet...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/MEG.0000000000000221

    authors: Qi X,Wu F,He C,Fan D,Han G

    更新日期:2015-01-01 00:00:00

  • Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.

    abstract:BACKGROUND:Hyperuricemia is a significant risk factor for nonalcoholic fatty liver disease (NAFLD). It may also have an impact on the histologic severity of NAFLD. However, data on this association are limited. We conducted this meta-analysis to investigate the relationship of serum uric acid with liver histologic seve...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MEG.0000000000000931

    authors: Jaruvongvanich V,Ahuja W,Wirunsawanya K,Wijarnpreecha K,Ungprasert P

    更新日期:2017-09-01 00:00:00

  • The extent of duodenogastric reflux in gastro-oesophageal reflux disease.

    abstract:BACKGROUND:It is known that duodenogastro-oesophageal reflux (DGOR) increases with worsening gastro-oesophageal reflux disease (GORD). It is unclear whether this is accompanied by increasing duodenogastric reflux (DGR). OBJECTIVE:To investigate the extent of DGR in a control group and 66 patients with GORD, using the ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200101000-00002

    authors: Marshall RE,Anggiansah A,Owen WA,Manifold DK,Owen WJ

    更新日期:2001-01-01 00:00:00

  • Management of bleeding gastric varices: a single session of histoacryl injection may be sufficient.

    abstract:OBJECTIVE:Gastric variceal bleeding is one of the most feared complications of portal hypertension and hence merits investigation for its optimal therapy. We aimed to evaluate the efficacy and long-term outcome(s) of patients treated with a single session of histoacryl sclerotherapy for active gastric variceal bleeding...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000080

    authors: Khawaja A,Sonawalla AA,Somani SF,Abid S

    更新日期:2014-06-01 00:00:00

  • A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy.

    abstract:BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL). The modalities of treatment of MHE have not been adequately studied. AIMS:To compare lactulose, probiotics, and L-ornithine L-aspartate (LOLA) in treatment of MHE and effect on HRQoL by Sickness Impact...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MEG.0b013e32834696f5

    authors: Mittal VV,Sharma BC,Sharma P,Sarin SK

    更新日期:2011-08-01 00:00:00

  • Trends in incidence of oesophageal and stomach cancer subtypes in Europe.

    abstract:OBJECTIVE:Time trend studies in the USA have shown that the incidences of adenocarcinomas of the oesophagus and gastric cardia have risen strongly since the 1970s, whereas the incidence of squamous cell carcinomas of the oesophagus has declined. Earlier, we found that the incidence of these adenocarcinomas also rose in...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e32832ca091

    authors: Steevens J,Botterweck AA,Dirx MJ,van den Brandt PA,Schouten LJ

    更新日期:2010-06-01 00:00:00

  • Pancreatic adenocarcinoma with histologically proven portal vein infiltration: what is the outcome?

    abstract:OBJECTIVES:Technical feasibility and safety of portal vein (PV) and superior mesenteric vein (SMV) resection during pancreaticoduodenectomy (PD) for cancer has been confirmed, but oncological benefits remain unclear. The present study aimed to explore the long-term outcomes of PD with PV/SMV resection and proven histol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000001266

    authors: Martin D,Petermann D,Fontanella S,Pu Y,Halkic N,Demartines N,Schäfer M

    更新日期:2018-12-01 00:00:00

  • Audit of a Barrett's epithelium surveillance database.

    abstract:BACKGROUND:Barrett's epithelium is a premalignant condition in which endoscopic surveillance is recommended but remains contentious. AIM:To audit our Barrett's epithelium surveillance database and to calculate the incidence and natural history of dysplasia and cancer in this cohort. METHODS:A retrospective analysis o...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200402000-00008

    authors: Basu KK,Pick B,de Caestecker JS

    更新日期:2004-02-01 00:00:00

  • Should relatives of coeliacs with mild clinical complaints undergo a small-bowel biopsy despite negative serology?

    abstract:BACKGROUND AND OBJECTIVES:Small intestinal lesions in coeliac disease (CD) have a variable severity. Early diagnosis of CD is important because treatment allows a normal psycho-physical development, especially in children, and can avoid associated disorders. The aim of this study was to evaluate the predictive value of...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200012010-00010

    authors: Rostami K,Mulder CJ,van Overbeek FM,Kerckhaert J,Meijer JW,von Blomberg MB,Heymans HS

    更新日期:2000-01-01 00:00:00

  • Occult obstetric trauma and anal incontinence.

    abstract::Obstetric trauma is by far the commonest cause of anal incontinence in women. Denervation and reinnervation of the pelvic floor and anal sphincter following vaginal delivery has been previously demonstrated. The advent of anal endosonography, however, has enabled the identification of occult anal sphincter defects fol...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-199705000-00002

    authors: Sultan AH,Stanton SL

    更新日期:1997-05-01 00:00:00

  • Lycopodium similiaplex-induced acute hepatitis: a case report.

    abstract::A 46-year-old woman was admitted to our department with symptoms of nausea, anorexia and asthenia. Serum alanine aminotransferase and aspartate aminotransferase levels were increased; all serological tests for viral hepatitis and autoimmune disorders were negative. She had taken Lycopodium similiaplex solution as seda...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e3282f1623d

    authors: Conti E,De Checchi G,Mencarelli R,Pinato S,Rovere P

    更新日期:2008-05-01 00:00:00

  • Infected retroperitoneal pelvic necrosis in severe acute pancreatitis: how can we manage it?

    abstract:OBJECTIVES:Retroperitoneal necrosis in the pelvic cavity is a rare complication of severe acute pancreatitis (SAP), mainly developing in critically ill patients. Because of its particular anatomy, it is difficult to perform drainage or surgery. We hypothesized that computed tomography (CT)-guided drainage is an effecti...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0000000000000305

    authors: Shen X,Tong Z,Li W,Li N,Li J

    更新日期:2015-04-01 00:00:00

  • Gastric hepatoid adenocarcinoma and familial investigation: does it always produce alpha-fetoprotein?

    abstract::We present the case of a 68-year-old Caucasian man with gastric hepatoid adenocarcinoma without increased levels of alpha-fetoprotein (AFP) in the serum. The patient had a strong history of gastric cancer in his family, affecting seven members, including a brother and a sister. The patient underwent subtotal gastrecto...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200311000-00015

    authors: Trompetas V,Varsamidakis N,Frangia K,Polimeropoulos V,Kalokairinos E

    更新日期:2003-11-01 00:00:00

  • Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease: a multicentre randomized placebo-controlled trial. German Budesonide Study Group.

    abstract:OBJECTIVE:Endoscopic recurrence of Crohn's disease frequently occurs within weeks after 'curative' operation. Treatment with 3 x 1 mg oral pH-modified release budesonide was tried to prevent postoperative recurrence. DESIGN:A multicentre randomized double-blind placebo-controlled trial of 1 year duration was performed...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00042737-199903000-00011

    authors: Ewe K,Böttger T,Buhr HJ,Ecker KW,Otto HF

    更新日期:1999-03-01 00:00:00

  • Gastric ulcers and Helicobacter heilmannii.

    abstract:OBJECTIVE:To compare 14 patients with gastric ulcer and Helicobacter heilmannii with other patients with gastric ulcer: age and sex matched patients, patients colonized by Helicobacter pylori and patients on nonsteroidal anti-inflammatory drugs (NSAIDs). SETTING:The endoscopy unit of a university-affiliated hospital. ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199803000-00011

    authors: Debongnie JC,Donnay M,Mairesse J,Lamy V,Dekoninck X,Ramdani B

    更新日期:1998-03-01 00:00:00

  • Ileal aberrant pancreas induces intussusception and gastrointestinal bleeding in an adult woman--case report.

    abstract::Aberrant pancreas is a congenital anomaly. In surgical series, its incidence varied from 0.2 to 0.8%. About 70% of aberrant pancreas occur in the gastrointestinal tract. Eighty percent of them locate in the stomach and duodenum, and only 0.2% in the ileum. We report on a 25-year-old woman with ileal aberrant pancreas ...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-199910000-00017

    authors: Huang WS,Kuo CH,Changchien CS,Hsu KL,Lin CC

    更新日期:1999-10-01 00:00:00

  • Sonographic diagnosis of coeliac disease in a case with suspected acute liver failure.

    abstract::Mild liver dysfunction occurs in patients with coeliac disease frequently, but severe liver diseases in combination with coeliac disease are rare. A 19-year-old woman was referred for evaluation for emergency liver transplantation with progressive jaundice and prolongation of prothrombin time. She had a history of non...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200509000-00018

    authors: Schmidt B,Novacek G,Brichta A,Vogelsang H,Wrba F,Ferenci P

    更新日期:2005-09-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and their colonic effects: more interesting than irritating?

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) have both beneficial and deleterious effects on the colon. Long-term use is associated with a substantial decrease in colorectal cancer incidence and regression of adenomatous polyps. In contrast, significant adverse effects are also interesting, but rare, and include muco...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 评论,杂志文章

    doi:10.1097/00042737-200211000-00003

    authors: Mulcahy HE,O'Donoghue D

    更新日期:2002-11-01 00:00:00

  • Treatment of refractory post-transjugular portosystemic stent-shunt encephalopathy: a novel case of stent luminal reduction.

    abstract::Encephalopathy is a significant complication of transjugular intrahepatic portosystemic stent-shunt (TIPSS). The majority respond to medical treatment but a proportion prove recalcitrant to conservative measures and eventually require some modulation of shunt blood flow in order to ameliorate their symptoms. This is p...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200412000-00025

    authors: Clarke G,Patel R,Tsao S,Blanshard K

    更新日期:2004-11-01 00:00:00

  • Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases.

    abstract:BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by a breakdown of colon epithelial barrier function. Antimicrobial peptides like cathelicidins are molecules of the innate immune system located at epithelial surfaces. Cathelicidins influence microbial growth and inflammation and may play a role in IBD. I...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200606000-00007

    authors: Schauber J,Rieger D,Weiler F,Wehkamp J,Eck M,Fellermann K,Scheppach W,Gallo RL,Stange EF

    更新日期:2006-06-01 00:00:00

  • Cost-effectiveness and long-term impact of Helicobacter pylori 'test and treat' service in reducing open access endoscopy referrals.

    abstract:INTRODUCTION:We have shown that the introduction of a carbon urea breath test (13C-UBT) service for Helicobacter pylori screening and eradication is effective in reducing the rate of open access endoscopy referrals in patients aged < 40 years in the short term. This has been substantiated by several randomized controll...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/00042737-200410000-00005

    authors: Sreedharan A,Clough M,Hemingbrough E,Gatta L,Chalmers DM,Axon AT,Moayyedi P

    更新日期:2004-10-01 00:00:00

  • Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma.

    abstract:OBJECTIVE:Liver cirrhosis is considered as a premalignant state, as about 80% of hepatocellular carcinoma (HCC) is associated with liver cirrhosis. Although alpha-fetoprotein (AFP) has a high negative predictive value, its sensitivity for detecting HCC is poor. The aim of this study was to evaluate circulating endoglin...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e3282202bea

    authors: Yagmur E,Rizk M,Stanzel S,Hellerbrand C,Lammert F,Trautwein C,Wasmuth HE,Gressner AM

    更新日期:2007-09-01 00:00:00

  • Non-surgical therapies of hepatocellular carcinoma.

    abstract::Early detection of hepatocellular carcinoma (HCC) through surveillance programmes allows potentially curative therapies such as resection, liver transplantation and percutaneous ablation to be applied in 40% of the patients. In non-surgical candidates, percutaneous treatments are the best therapeutic approach, and may...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,评审

    doi:10.1097/00042737-200505000-00006

    authors: Llovet JM,Sala M

    更新日期:2005-05-01 00:00:00

  • Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatic fibrosis. Liver biopsy, because of its limitations and risks, might be considered an imperfect gold standard for assessing the severity of chronic liver diseases. In this study, we aimed to prospectively validate FibroTest (FT) and Act...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/MEG.0b013e328336ec84

    authors: El-Shabrawi MH,Mohsen NA,Sherif MM,El-Karaksy HM,Abou-Yosef H,El-Sayed HM,Riad H,Bahaa N,Isa M,El-Hennawy A

    更新日期:2010-08-01 00:00:00

  • Hepatitis C treatment for multimorbid patients with substance use disorder in a primary care-based integrated treatment centre: a retrospective analysis.

    abstract:OBJECTIVES/BACKGROUND:The population of people who use drugs (PWUD) has the highest prevalence of hepatitis C virus (HCV) infections in Europe. PWUD are multimorbid patients who are difficult to integrate into existing healthcare systems. In our study, we evaluated the feasibility of providing HCV treatment within opio...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MEG.0b013e32836140bb

    authors: Brunner N,Senn O,Rosemann T,Falcato L,Bruggmann P

    更新日期:2013-11-01 00:00:00

  • Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin.

    abstract:OBJECTIVE:To assess the accuracy of the determination of Helicobacter pylori infection by a stool immunoassay in patients with upper-gastrointestinal bleeding (UGB) of peptic origin, in comparison with the routine histological study, serology, rapid urease and 13C-breath tests. METHODS:Sixty-eight patients with endosc...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:10.1097/01.meg.0000059114.41030.a9

    authors: Griñó P,Pascual S,Such J,Casellas JA,Niveiro M,Andreu M,Sáez J,Aparicio JR,Griñó E,Compañy L,Laveda R,Pérez-Mateo M

    更新日期:2003-05-01 00:00:00

  • Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation.

    abstract:BACKGROUND/AIMS:This study was aimed at determining if the frequency and pattern of acute liver failure (ALF) following halothane anaesthesia had decreased during the last 11 years in comparison with a previous series of 48 patients referred between 1965 and 1984 and whether clinical outcome had been altered by the int...

    journal_title:European journal of gastroenterology & hepatology

    pub_type: 杂志文章

    doi:

    authors: Lo SK,Wendon J,Mieli-Vergani G,Williams R

    更新日期:1998-08-01 00:00:00